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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Magnetic Resonance Spectroscopy

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Disease relevance of Magnetic Resonance Spectroscopy


Psychiatry related information on Magnetic Resonance Spectroscopy


High impact information on Magnetic Resonance Spectroscopy


Chemical compound and disease context of Magnetic Resonance Spectroscopy


Biological context of Magnetic Resonance Spectroscopy


Anatomical context of Magnetic Resonance Spectroscopy


Associations of Magnetic Resonance Spectroscopy with chemical compounds


Gene context of Magnetic Resonance Spectroscopy

  • Here we use two-dimensional NMR spectroscopy to determine the structure of an amino-terminal fragment of GAL4 (residues 1-65) [35].
  • One catheter needed to be repositioned and there were changes in the magnetic resonance images that disappeared after lowering the concentration of GDNF [36].
  • Here we describe the nuclear magnetic resonance structure of a region encompassing the second BIR domain (BIR2) of a human IAP family member, XIAP (also called hILP or MIHA) [37].
  • The three-dimensional structure of a member of the beta subfamily of chemokines, human macrophage inflammatory protein-1 beta (hMIP-1 beta), has been determined with the use of solution multidimensional heteronuclear magnetic resonance spectroscopy [38].
  • We further present the three-dimensional nuclear magnetic resonance structure of the CBP bromodomain in complex with a lysine 382-acetylated p53 peptide [39].

Analytical, diagnostic and therapeutic context of Magnetic Resonance Spectroscopy


  1. NMR structure of the bacteriophage lambda N peptide/boxB RNA complex: recognition of a GNRA fold by an arginine-rich motif. Legault, P., Li, J., Mogridge, J., Kay, L.E., Greenblatt, J. Cell (1998) [Pubmed]
  2. Diagnosis of pulmonary embolism with magnetic resonance angiography. Meaney, J.F., Weg, J.G., Chenevert, T.L., Stafford-Johnson, D., Hamilton, B.H., Prince, M.R. N. Engl. J. Med. (1997) [Pubmed]
  3. Abnormal myocardial phosphorus-31 nuclear magnetic resonance spectroscopy in women with chest pain but normal coronary angiograms. Buchthal, S.D., den Hollander, J.A., Merz, C.N., Rogers, W.J., Pepine, C.J., Reichek, N., Sharaf, B.L., Reis, S., Kelsey, S.F., Pohost, G.M. N. Engl. J. Med. (2000) [Pubmed]
  4. Solution structure of a pair of calcium-binding epidermal growth factor-like domains: implications for the Marfan syndrome and other genetic disorders. Downing, A.K., Knott, V., Werner, J.M., Cardy, C.M., Campbell, I.D., Handford, P.A. Cell (1996) [Pubmed]
  5. Structure of domain 1 of rat T lymphocyte CD2 antigen. Driscoll, P.C., Cyster, J.G., Campbell, I.D., Williams, A.F. Nature (1991) [Pubmed]
  6. Relation between age-related decline in intelligence and cerebral white-matter hyperintensities in healthy octogenarians: a longitudinal study. Garde, E., Mortensen, E.L., Krabbe, K., Rostrup, E., Larsson, H.B. Lancet (2000) [Pubmed]
  7. An in vivo study of phosphorus and glucose metabolism in Alzheimer's disease using magnetic resonance spectroscopy and PET. Murphy, D.G., Bottomley, P.A., Salerno, J.A., DeCarli, C., Mentis, M.J., Grady, C.L., Teichberg, D., Giacometti, K.R., Rosenberg, J.M., Hardy, C.J. Arch. Gen. Psychiatry (1993) [Pubmed]
  8. Brain morphology, dopamine, and eye-tracking abnormalities in first-episode schizophrenia. Prevalence and clinical correlates. Lieberman, J.A., Jody, D., Alvir, J.M., Ashtari, M., Levy, D.L., Bogerts, B., Degreef, G., Mayerhoff, D.I., Cooper, T. Arch. Gen. Psychiatry (1993) [Pubmed]
  9. The hippocampus in patients treated with electroconvulsive therapy: a proton magnetic resonance spectroscopic imaging study. Ende, G., Braus, D.F., Walter, S., Weber-Fahr, W., Henn, F.A. Arch. Gen. Psychiatry (2000) [Pubmed]
  10. Nonsyndromic mental retardation and cryptogenic epilepsy in women with doublecortin gene mutations. Guerrini, R., Moro, F., Andermann, E., Hughes, E., D'Agostino, D., Carrozzo, R., Bernasconi, A., Flinter, F., Parmeggiani, L., Volzone, A., Parrini, E., Mei, D., Jarosz, J.M., Morris, R.G., Pratt, P., Tortorella, G., Dubeau, F., Andermann, F., Dobyns, W.B., Das, S. Ann. Neurol. (2003) [Pubmed]
  11. A new gene, encoding an anion transporter, is mutated in sialic acid storage diseases. Verheijen, F.W., Verbeek, E., Aula, N., Beerens, C.E., Havelaar, A.C., Joosse, M., Peltonen, L., Aula, P., Galjaard, H., van der Spek, P.J., Mancini, G.M. Nat. Genet. (1999) [Pubmed]
  12. Measurement of the urinary lactate:creatinine ratio for the early identification of newborn infants at risk for hypoxic-ischemic encephalopathy. Huang, C.C., Wang, S.T., Chang, Y.C., Lin, K.P., Wu, P.L. N. Engl. J. Med. (1999) [Pubmed]
  13. Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A. Fernandez, I., Ubach, J., Dulubova, I., Zhang, X., Südhof, T.C., Rizo, J. Cell (1998) [Pubmed]
  14. Diagnosis of chronic manganese intoxication by magnetic resonance imaging. Arjona, A., Mata, M., Bonet, M. N. Engl. J. Med. (1997) [Pubmed]
  15. Newer tests for the diagnosis of renovascular disease. Davidson, R.A., Wilcox, C.S. JAMA (1992) [Pubmed]
  16. Foot infections in diabetic patients. Decision and cost-effectiveness analyses. Eckman, M.H., Greenfield, S., Mackey, W.C., Wong, J.B., Kaplan, S., Sullivan, L., Dukes, K., Pauker, S.G. JAMA (1995) [Pubmed]
  17. 19F and 1H MRI detection of amyloid beta plaques in vivo. Higuchi, M., Iwata, N., Matsuba, Y., Sato, K., Sasamoto, K., Saido, T.C. Nat. Neurosci. (2005) [Pubmed]
  18. 31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus. Rothman, D.L., Shulman, R.G., Shulman, G.I. J. Clin. Invest. (1992) [Pubmed]
  19. Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy. Häussinger, D., Laubenberger, J., vom Dahl, S., Ernst, T., Bayer, S., Langer, M., Gerok, W., Hennig, J. Gastroenterology (1994) [Pubmed]
  20. Conformation of the TAR RNA-arginine complex by NMR spectroscopy. Puglisi, J.D., Tan, R., Calnan, B.J., Frankel, A.D., Williamson, J.R. Science (1992) [Pubmed]
  21. How thiamine diphosphate is activated in enzymes. Kern, D., Kern, G., Neef, H., Tittmann, K., Killenberg-Jabs, M., Wikner, C., Schneider, G., Hübner, G. Science (1997) [Pubmed]
  22. DNA conformation, dynamics, and interactions in solution. Patel, D.J., Pardi, A., Itakura, K. Science (1982) [Pubmed]
  23. Structure of the RGD protein decorsin: conserved motif and distinct function in leech proteins that affect blood clotting. Krezel, A.M., Wagner, G., Seymour-Ulmer, J., Lazarus, R.A. Science (1994) [Pubmed]
  24. Shopping around for hospital services: a comparison of the United States and Canada. Bell, C.M., Crystal, M., Detsky, A.S., Redelmeier, D.A. JAMA (1998) [Pubmed]
  25. Docking phospholipase A2 on membranes using electrostatic potential-modulated spin relaxation magnetic resonance. Lin, Y., Nielsen, R., Murray, D., Hubbell, W.L., Mailer, C., Robinson, B.H., Gelb, M.H. Science (1998) [Pubmed]
  26. Metabolic abnormalities in skeletal muscle of patients receiving zidovudine therapy observed by 31P in vivo magnetic resonance spectroscopy. Sinnwell, T.M., Sivakumar, K., Soueidan, S., Jay, C., Frank, J.A., McLaughlin, A.C., Dalakas, M.C. J. Clin. Invest. (1995) [Pubmed]
  27. Functional imaging of perceptual learning in human primary and secondary somatosensory cortex. Pleger, B., Foerster, A.F., Ragert, P., Dinse, H.R., Schwenkreis, P., Malin, J.P., Nicolas, V., Tegenthoff, M. Neuron (2003) [Pubmed]
  28. Pulse-inversion contrast harmonic imaging: ultrasonographic assessment of cerebral perfusion. Meairs, S., Daffertshofer, M., Neff, W., Eschenfelder, C., Hennerici, M. Lancet (2000) [Pubmed]
  29. Association of demyelination with deficiency of cerebrospinal-fluid S-adenosylmethionine in inborn errors of methyl-transfer pathway. Surtees, R., Leonard, J., Austin, S. Lancet (1991) [Pubmed]
  30. Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. Perseghin, G., Price, T.B., Petersen, K.F., Roden, M., Cline, G.W., Gerow, K., Rothman, D.L., Shulman, G.I. N. Engl. J. Med. (1996) [Pubmed]
  31. Effect of triglyceride levels on methyl and methylene envelope line widths in proton nuclear magnetic resonance spectroscopy of human plasma. Mims, M.P., Morrisett, J.D., Mattioli, C.A., Gotto, A.M. N. Engl. J. Med. (1989) [Pubmed]
  32. Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine-guanine base pairs. Henderson, E., Hardin, C.C., Walk, S.K., Tinoco, I., Blackburn, E.H. Cell (1987) [Pubmed]
  33. Patient access to magnetic resonance imaging centers in Orange County, California. Morgan, B.C. N. Engl. J. Med. (1993) [Pubmed]
  34. Proton magnetic resonance study of the hydration of glucose. Harvey, J.M., Symons, M.C., Naftalin, R.J. Nature (1976) [Pubmed]
  35. Solution structure of the DNA-binding domain of Cd2-GAL4 from S. cerevisiae. Baleja, J.D., Marmorstein, R., Harrison, S.C., Wagner, G. Nature (1992) [Pubmed]
  36. Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Gill, S.S., Patel, N.K., Hotton, G.R., O'Sullivan, K., McCarter, R., Bunnage, M., Brooks, D.J., Svendsen, C.N., Heywood, P. Nat. Med. (2003) [Pubmed]
  37. NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP. Sun, C., Cai, M., Gunasekera, A.H., Meadows, R.P., Wang, H., Chen, J., Zhang, H., Wu, W., Xu, N., Ng, S.C., Fesik, S.W. Nature (1999) [Pubmed]
  38. High-resolution solution structure of the beta chemokine hMIP-1 beta by multidimensional NMR. Lodi, P.J., Garrett, D.S., Kuszewski, J., Tsang, M.L., Weatherbee, J.A., Leonard, W.J., Gronenborn, A.M., Clore, G.M. Science (1994) [Pubmed]
  39. Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. Mujtaba, S., He, Y., Zeng, L., Yan, S., Plotnikova, O., Sachchidanand, n.u.l.l., Sanchez, R., Zeleznik-Le, N.J., Ronai, Z., Zhou, M.M. Mol. Cell (2004) [Pubmed]
  40. The diagnosis and medical management of advanced neuroendocrine tumors. Kaltsas, G.A., Besser, G.M., Grossman, A.B. Endocr. Rev. (2004) [Pubmed]
  41. Solution structures of beta peptide and its constituent fragments: relation to amyloid deposition. Barrow, C.J., Zagorski, M.G. Science (1991) [Pubmed]
  42. Observation of covalent intermediates in an enzyme mechanism at atomic resolution. Heine, A., DeSantis, G., Luz, J.G., Mitchell, M., Wong, C.H., Wilson, I.A. Science (2001) [Pubmed]
  43. Decreased brain choline uptake in older adults. An in vivo proton magnetic resonance spectroscopy study. Cohen, B.M., Renshaw, P.F., Stoll, A.L., Wurtman, R.J., Yurgelun-Todd, D., Babb, S.M. JAMA (1995) [Pubmed]
  44. Unmyelinated tactile afferents signal touch and project to insular cortex. Olausson, H., Lamarre, Y., Backlund, H., Morin, C., Wallin, B.G., Starck, G., Ekholm, S., Strigo, I., Worsley, K., Vallbo, A.B., Bushnell, M.C. Nat. Neurosci. (2002) [Pubmed]
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