Disease relevance of Iso-Bid

• 12 patients with coronary heart disease were studied to see whether high doses of isosorbide dinitrate (ISDN, Corovliss) or isosorbide 5-mononitrate (IS-5-MN, Ismo) increase the erythrocyte methemoglobin production in an acute experiment and after 4 days of medication [1].
• Evaluation was made on the efficacy of isosorbide dinitrate tape (ISDN tape, TY-0081, Frandol Tape), a preparation newly developed in Japan, regarding the relationship between the exercise tolerance in patients with stable effort angina pectoris and plasma concentrations of ISDN [2].

High impact information on Iso-Bid

• Isochron-based phase response analysis of circadian rhythms [3].
• All these results were compared with the commercial product Frandol(R) Tape S from Japan. It was found that the release rate of Frandol was close to target release rate and fitted matrix kinetics [4].
• In contrast, isosorbide-2,5-dinitrate (ISDN, 1 microM) inhibited ALDH3 activity (1.1 +/- 0.4% of control) but did not inhibit ALDH2 activity even up to 50 microM ISDN [5].
• With the isochron method, Dext can be derived easily during the ESR analysis [6].
• LU dates estimated from isochron plots average 204 +/- 86 ka, while LU ages calculated with the average isochron-derived gamma ext = 10.79 +/- 1.89 mrad/a average 220 +/- 62 ka [7].

References