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Chemical Compound Review

Isodinit     [(1S,2S,5S,6R)-6-nitrooxy- 4,8...

Synonyms: Isotrate, Sorbonit, Dilatrate, Isordil, IsoBid, ...
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Disease relevance of Iso-Bid

  • 12 patients with coronary heart disease were studied to see whether high doses of isosorbide dinitrate (ISDN, Corovliss) or isosorbide 5-mononitrate (IS-5-MN, Ismo) increase the erythrocyte methemoglobin production in an acute experiment and after 4 days of medication [1].
  • Evaluation was made on the efficacy of isosorbide dinitrate tape (ISDN tape, TY-0081, Frandol Tape), a preparation newly developed in Japan, regarding the relationship between the exercise tolerance in patients with stable effort angina pectoris and plasma concentrations of ISDN [2].

High impact information on Iso-Bid

  • Isochron-based phase response analysis of circadian rhythms [3].
  • All these results were compared with the commercial product Frandol(R) Tape S from Japan. It was found that the release rate of Frandol was close to target release rate and fitted matrix kinetics [4].
  • In contrast, isosorbide-2,5-dinitrate (ISDN, 1 microM) inhibited ALDH3 activity (1.1 +/- 0.4% of control) but did not inhibit ALDH2 activity even up to 50 microM ISDN [5].
  • With the isochron method, Dext can be derived easily during the ESR analysis [6].
  • LU dates estimated from isochron plots average 204 +/- 86 ka, while LU ages calculated with the average isochron-derived gamma ext = 10.79 +/- 1.89 mrad/a average 220 +/- 62 ka [7].


  1. Differences in the production of methemoglobin during high-dose treatment with isosorbide dinitrate or isosorbide 5-mononitrate. Schneider, W., Stahl, B., Kaltenbach, M., Bussmann, W.D. Arzneimittel-Forschung. (1984) [Pubmed]
  2. Efficacy of isosorbide dinitrate tape on exercise tolerance of patients with angina pectoris. Saito, M., Nobuyoshi, M., Nakamura, N., Nishiyama, S., Haze, K., Hiramori, K., Ikeda, M. Arzneimittel-Forschung. (1983) [Pubmed]
  3. Isochron-based phase response analysis of circadian rhythms. Gunawan, R., Doyle, F.J. Biophys. J. (2006) [Pubmed]
  4. Development of a membrane-controlled transdermal therapeutic system containing isosorbide dinitrate. Ocak, F., Ağabeyoğlu, I. International journal of pharmaceutics. (1999) [Pubmed]
  5. Nitrate-based vasodilators inhibit multiple vascular aldehyde dehydrogenases. Murphy, T.C., Arntzen, R., Picklo, M.J. Cardiovasc. Toxicol. (2005) [Pubmed]
  6. ESR isochron dating for teeth: a brief demonstration in solving the external dose calculation problem. Blackwell, B.A., Schwarcz, H.P. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. (1993) [Pubmed]
  7. ESR dating tooth enamel from the Paleolithic site at Longola, Zambia. Blackwell, B.A., Schwarcz, H.P., Schick, K., Toth, N. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. (1993) [Pubmed]
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