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MeSH Review

Exercise Tolerance

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Disease relevance of Exercise Tolerance


Psychiatry related information on Exercise Tolerance


High impact information on Exercise Tolerance


Chemical compound and disease context of Exercise Tolerance


Biological context of Exercise Tolerance


Anatomical context of Exercise Tolerance


Associations of Exercise Tolerance with chemical compounds


Gene context of Exercise Tolerance

  • RESULTS: Exercise tolerance was reduced in patients with RA and patients with SLE, as reflected by peak VO2 and LT, but muscle energetics were not altered [36].
  • GH treatment may have beneficial effects on both growth and exercise tolerance without serious complications in prepubertal children with CF [37].
  • The literature about GH treatment and its effect on exercise tolerance are rather limited, not always consistent and methodological concerns restrict further analysis [37].
  • Mean values for PF4 and beta TG at rest, during each stage, and immediately after treadmill exercise were the same for normal subjects and for patients with positive and negative responses to exercise-tolerance tests (ETTs) [38].
  • The elevated RNase L enzyme activity observed in some Chronic Fatigue Syndrome (CFS) patients may be linked to the low exercise tolerance and functional impairment that typify this disease [39].

Analytical, diagnostic and therapeutic context of Exercise Tolerance


  1. Effect of captopril on progressive ventricular dilatation after anterior myocardial infarction. Pfeffer, M.A., Lamas, G.A., Vaughan, D.E., Parisi, A.F., Braunwald, E. N. Engl. J. Med. (1988) [Pubmed]
  2. Long-term treatment of primary pulmonary hypertension with continuous intravenous epoprostenol (prostacyclin). Higenbottam, T., Wheeldon, D., Wells, F., Wallwork, J. Lancet (1984) [Pubmed]
  3. Diltiazem, nifedipine, and their combination in patients with stable angina pectoris: effects on angina, exercise tolerance, and the ambulatory electrocardiographic ST segment. Frishman, W., Charlap, S., Kimmel, B., Teicher, M., Cinnamon, J., Allen, L., Strom, J. Circulation (1988) [Pubmed]
  4. Inhibition of dipyridamole-induced ischemia by antianginal therapy in humans. Correlation with exercise electrocardiography. Lattanzi, F., Picano, E., Bolognese, L., Piccinino, C., Sarasso, G., Orlandini, A., L'Abbate, A. Circulation (1991) [Pubmed]
  5. A multivariate approach for interpreting treadmill exercise tests in coronary artery disease. Berman, J.L., Wynne, J., Cohn, P.F. Circulation (1978) [Pubmed]
  6. Strenuous physical activity, treadmill exercise test performance and plasma high-density lipoprotein cholesterol.The Lipid Research Clinics Program Prevalence Study. Haskell, W.L., Taylor, H.L., Wood, P.D., Schrott, H., Heiss, G. Circulation (1980) [Pubmed]
  7. Sildenafil citrate does not reduce exercise tolerance in men with erectile dysfunction and chronic stable angina. Fox, K.M., Thadani, U., Ma, P.T., Nash, S.D., Keating, Z., Czorniak, M.A., Gillies, H., Keltai, M. Eur. Heart J. (2003) [Pubmed]
  8. Pharmacokinetic factors in the clinical use of tryptophan. Hedaya, R.J. Journal of clinical psychopharmacology. (1984) [Pubmed]
  9. Megestrol acetate stimulates weight gain and ventilation in underweight COPD patients. Weisberg, J., Wanger, J., Olson, J., Streit, B., Fogarty, C., Martin, T., Casaburi, R. Chest (2002) [Pubmed]
  10. Reversibility of the analgesic effect of meptazinol in volunteers. Warrington, S.J., Barclay, S.P., Brown, Z., Robson, P.J. Postgraduate medical journal. (1983) [Pubmed]
  11. A comparison of oral milrinone, digoxin, and their combination in the treatment of patients with chronic heart failure. DiBianco, R., Shabetai, R., Kostuk, W., Moran, J., Schlant, R.C., Wright, R. N. Engl. J. Med. (1989) [Pubmed]
  12. Heart-lung transplantation: successful therapy for patients with pulmonary vascular disease. Reitz, B.A., Wallwork, J.L., Hunt, S.A., Pennock, J.L., Billingham, M.E., Oyer, P.E., Stinson, E.B., Shumway, N.E. N. Engl. J. Med. (1982) [Pubmed]
  13. Effects of dihydrocodeine, alcohol, and caffeine on breathlessness and exercise tolerance in patients with chronic obstructive lung disease and normal blood gases. Woodcock, A.A., Gross, E.R., Gellert, A., Shah, S., Johnson, M., Geddes, D.M. N. Engl. J. Med. (1981) [Pubmed]
  14. Comparison of the immediate effects of five beta-adrenoreceptor-blocking drugs with different ancillary properties in angina pectoris. Thadani, U., Davidson, C., Singleton, W., Taylor, S.H. N. Engl. J. Med. (1979) [Pubmed]
  15. Alpha-adrenoceptor-mediated coronary artery spasm. Levene, D.L., Freeman, M.R. JAMA (1976) [Pubmed]
  16. Value of digoxin in heart failure and sinus rhythm: new features of an old drug? van Veldhuisen, D.J., de Graeff, P.A., Remme, W.J., Lie, K.I. J. Am. Coll. Cardiol. (1996) [Pubmed]
  17. Enhanced external counterpulsation improves exercise tolerance, reduces exercise-induced myocardial ischemia and improves left ventricular diastolic filling in patients with coronary artery disease. Urano, H., Ikeda, H., Ueno, T., Matsumoto, T., Murohara, T., Imaizumi, T. J. Am. Coll. Cardiol. (2001) [Pubmed]
  18. Effect of labetalol on exercise tolerance and double product in mild to moderate essential hypertension. Feit, A., Holtzman, R., Cohen, M., el-Sherif, N. Am. J. Med. (1985) [Pubmed]
  19. 17-beta-Estradiol therapy lessens angina in postmenopausal women with syndrome X. Rosano, G.M., Peters, N.S., Lefroy, D., Lindsay, D.C., Sarrel, P.M., Collins, P., Poole-Wilson, P.A. J. Am. Coll. Cardiol. (1996) [Pubmed]
  20. Beneficial effects of low dose amiodarone in patients with congestive cardiac failure: a placebo-controlled trial. Hamer, A.W., Arkles, L.B., Johns, J.A. J. Am. Coll. Cardiol. (1989) [Pubmed]
  21. The effect of caffeine on exercise tolerance and left ventricular function in patients with coronary artery disease. Hirsch, A.T., Gervino, E.V., Nakao, S., Come, P.C., Silverman, K.J., Grossman, W. Ann. Intern. Med. (1989) [Pubmed]
  22. Beta-adrenergic stimulation of the failing ventricle: a double-blind, randomized trial of sustained oral therapy with prenalterol. Roubin, G.S., Choong, C.Y., Devenish-Meares, S., Sadick, N.N., Fletcher, P.J., Kelly, D.T., Harris, P.J. Circulation (1984) [Pubmed]
  23. Effects of increasing maintenance dose of digoxin on left ventricular function and neurohormones in patients with chronic heart failure treated with diuretics and angiotensin-converting enzyme inhibitors. Gheorghiade, M., Hall, V.B., Jacobsen, G., Alam, M., Rosman, H., Goldstein, S. Circulation (1995) [Pubmed]
  24. Energy metabolism in uncoupling protein 3 gene knockout mice. Vidal-Puig, A.J., Grujic, D., Zhang, C.Y., Hagen, T., Boss, O., Ido, Y., Szczepanik, A., Wade, J., Mootha, V., Cortright, R., Muoio, D.M., Lowell, B.B. J. Biol. Chem. (2000) [Pubmed]
  25. Losartan improves exercise tolerance in patients with diastolic dysfunction and a hypertensive response to exercise. Warner, J.G., Metzger, D.C., Kitzman, D.W., Wesley, D.J., Little, W.C. J. Am. Coll. Cardiol. (1999) [Pubmed]
  26. Skeletal muscle weakness, reduced exercise tolerance, and COPD: is systemic inflammation the missing link? Sin, D.D., Man, S.F. Thorax (2006) [Pubmed]
  27. Long-term effectiveness of pulmonary rehabilitation in patients with chronic airway obstruction. Foglio, K., Bianchi, L., Bruletti, G., Battista, L., Pagani, M., Ambrosino, N. Eur. Respir. J. (1999) [Pubmed]
  28. Adenoviral-mediated transfer of vascular endothelial growth factor 121 cDNA enhances myocardial perfusion and exercise performance in the nonischemic state. Schalch, P., Rahman, G.F., Patejunas, G., Goldschmidt, R.A., Carbray, J., Retuerto, M.A., Kim, D., Esser, K., Crystal, R.G., Rosengart, T.K. J. Thorac. Cardiovasc. Surg. (2004) [Pubmed]
  29. Cyclandelate: effect on circulatory measurements and exercise tolerance in chronic arterial insufficiency of the lower limbs. Reich, T. Journal of the American Geriatrics Society. (1977) [Pubmed]
  30. Nitroglycerin-induced improvement in exercise tolerance and hemodynamics in patients with chronic rheumatic heart valve disease. Borer, J.S., Redwood, D.R., Itscoitz, S.B., Goldstein, R.E., Epstein, S.E. Am. J. Cardiol. (1978) [Pubmed]
  31. Adjuvant xamoterol or metoprolol in patients with malignant ventricular arrhythmia resistant to amiodarone. Paul, V., Griffith, M., Ward, D.E., Camm, A.J. Lancet (1989) [Pubmed]
  32. Primary pulmonary hypertension. Gaine, S.P., Rubin, L.J. Lancet (1998) [Pubmed]
  33. Symptomatic assessment of patients with heart failure: double-blind comparison of increasing doses of diuretics and captopril in moderate heart failure. Cowley, A.J., Stainer, K., Wynne, R.D., Rowley, J.M., Hampton, J.R. Lancet (1986) [Pubmed]
  34. Avoiding unsuspected respiratory side-effects of topical timolol with cardioselective or sympathomimetic agents. Diggory, P., Cassels-Brown, A., Vail, A., Abbey, L.M., Hillman, J.S. Lancet (1995) [Pubmed]
  35. Comparison of vasopeptidase inhibitor, omapatrilat, and lisinopril on exercise tolerance and morbidity in patients with heart failure: IMPRESS randomised trial. Rouleau, J.L., Pfeffer, M.A., Stewart, D.J., Isaac, D., Sestier, F., Kerut, E.K., Porter, C.B., Proulx, G., Qian, C., Block, A.J. Lancet (2000) [Pubmed]
  36. Serum cortisol reduction and abnormal prolactin and CD4+/CD8+ T-cell response as a result of controlled exercise in patients with rheumatoid arthritis and systemic lupus erythematosus despite unaltered muscle energetics. Pool, A.J., Whipp, B.J., Skasick, A.J., Alavi, A., Bland, J.M., Axford, J.S. Rheumatology (Oxford, England) (2004) [Pubmed]
  37. Growth hormone and exercise tolerance in patients with cystic fibrosis. Hütler, M., Beneke, R. Sports medicine (Auckland, N.Z.) (2004) [Pubmed]
  38. Serial studies of platelet factor 4 and beta thromboglobulin during exercise in patients with coronary artery disease. Strauss, W.E., Cella, G., Parisi, A.F., Sasahara, A.A. Am. Heart J. (1985) [Pubmed]
  39. Physical performance and prediction of 2-5A synthetase/RNase L antiviral pathway activity in patients with chronic fatigue syndrome. Snell, C.R., Vanness, J.M., Strayer, D.R., Stevens, S.R. In Vivo (2002) [Pubmed]
  40. Drug-induced conditioning in congestive heart failure. Leier, C.V., Huss, P., Lewis, R.P., Unverferth, D.V. Circulation (1982) [Pubmed]
  41. Use of calcium channel blockers in hypertrophic cardiomyopathy. Lorell, B.H. Am. J. Med. (1985) [Pubmed]
  42. Effort angina with adequate beta-receptor blockade: comparison with diltiazem alone and in combination. Humen, D.P., O'Brien, P., Purves, P., Johnson, D., Kostuk, W.J. J. Am. Coll. Cardiol. (1986) [Pubmed]
  43. Influence of angiotensin converting enzyme inhibition on exercise performance and clinical symptoms in chronic heart failure: a multicentre, double-blind, placebo-controlled trial. Dössegger, L., Aldor, E., Baird, M.G., Braun, S., Cleland, J.G., Donaldson, R., Jansen, L.J., Joy, M.D., Marin-Neto, J.A., Nogueira, E. Eur. Heart J. (1993) [Pubmed]
  44. Duration and extent of antianginal effects of a sustained-release formulation of nifedipine in angina. Yokota, M., Saito, F., Izawa, H., Matsunami, T., Yoshida, J., Inagaki, H., Sotobata, I. Eur. Heart J. (1994) [Pubmed]
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