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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

diethylsulfone     1-ethylsulfonylethane

Synonyms: Ethyl sulfone, ACMC-1AKBI, NSC-145719, AC1L2AWM, AC1Q6UZR, ...
 
 
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High impact information on NSC 145719

  • Teratogenicity of the ethyl sulfone (which shows marked inhibition of chondrogenesis in cultured limb bud) does not appear to depend on measurable concentrations of these sulfinic/sulfonic acid metabolites in the hamster embryo [1].
  • Plasma analyses by HPLC suggested that the ethyl sulfone was oxidized and appeared in maternal plasma as the corresponding sulfinic (Ro 14-9572) and sulfonic (Ro 14-3899) acids, amounting to 10% and 16%, respectively, of the mean maternal ethyl sulfone Cmax value [1].

References

  1. Comparative disposition, receptor affinity, and teratogenic activity of sulfon arotinoids. Willhite, C.C., Dubois, A., Schindler-Horvat, J., Apfel, C., Eckhoff, C. Teratology (1995) [Pubmed]
 
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