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Chemical Compound Review

CHEMBL305107     6-methoxy-7H-purine

Synonyms: SureCN284829, SureCN284830, ACMC-1C2X2, AG-C-08515, ANW-15812, ...
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Disease relevance of NSC 23723


High impact information on NSC 23723


Biological context of NSC 23723


Associations of NSC 23723 with other chemical compounds

  • The transport of the anti-varicella-zoster virus agent 6-methoxypurine arabinoside and its 2'-O-valerate prodrug, 170U88, was investigated by using the human erythrocyte model [5].


  1. Anabolic pathway of 6-methoxypurine arabinoside in cells infected with varicella-zoster virus. de Miranda, P., Burnette, T.C., Biron, K.K., Miller, R.L., Averett, D.R., Krenitsky, T.A. Antimicrob. Agents Chemother. (1991) [Pubmed]
  2. Retinal toxicity of 6-methoxypurine arabinoside (ara-M). A new selective and potent inhibitor of varicella-zoster virus. Karaçorlu, S., Peyman, G.A., Karaçorlu, M., Dunlap, W., Soike, K.F. Retina (Philadelphia, Pa.) (1992) [Pubmed]
  3. Neurotoxic effects of the anti-varicella zoster virus agent 2'-valeryl-6-methoxypurine arabinoside in monkeys and rats dosed orally for 90 days. Szczech, G.M., Tucker, W.E. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1992) [Pubmed]
  4. Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy. Huber, B.E., Richards, C.A., Krenitsky, T.A. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  5. Transport of the anti-varicella-zoster virus agent 6-methoxypurine arabinoside and its 2'-O-valerate prodrug into human erythrocytes. Prus, K.L., Heidenreich, A.C., Zimmerman, T.P. Antimicrob. Agents Chemother. (1992) [Pubmed]
  6. Metabolic disposition and pharmacokinetics of the antiviral agent 6-methoxypurine arabinoside in rats and monkeys. Burnette, T.C., Koszalka, G.W., Krenitsky, T.A., De Miranda, P. Antimicrob. Agents Chemother. (1991) [Pubmed]
  7. 6-Methoxypurine arabinoside as a selective and potent inhibitor of varicella-zoster virus. Averett, D.R., Koszalka, G.W., Fyfe, J.A., Roberts, G.B., Purifoy, D.J., Krenitsky, T.A. Antimicrob. Agents Chemother. (1991) [Pubmed]
  8. A unique unnatural base pair between a C analogue, pseudoisocytosine, and an A analogue, 6-methoxypurine, in replication. Hirao, I., Kimoto, M., Yamakage, S., Ishikawa, M., Kikuchi, J., Yokoyama, S. Bioorg. Med. Chem. Lett. (2002) [Pubmed]
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