Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Premafloxacin 1-cyclopropyl-6-fluoro-8- methoxy-7-[(3R)-3...

Synonyms: JB-1, CHEMBL230599, AG-K-19847, SureCN1230382, CHEBI:483491, ...

Ince, D. et al., Wang, M. et al.

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Disease relevance of U-95376

Mechanisms and frequency of resistance to premafloxacin in Staphylococcus aureus: novel mutations suggest novel drug-target interactions [1].

High impact information on U-95376

Sitafloxacin, BAYy3118, and premafloxacin had higher activity in vitro than ciprofloxacin against transconjugants and donors containing qnr [2].
A double mutation (gyrA and either grlA or grlB) caused a 32-fold increase in the MIC of premafloxacin, while the MIC of ciprofloxacin increased 128-fold [1].

References

Mechanisms and frequency of resistance to premafloxacin in Staphylococcus aureus: novel mutations suggest novel drug-target interactions. Ince, D., Hooper, D.C. Antimicrob. Agents Chemother. (2000) [Pubmed]
Activities of newer quinolones against Escherichia coli and Klebsiella pneumoniae containing the plasmid-mediated quinolone resistance determinant qnr. Wang, M., Sahm, D.F., Jacoby, G.A., Zhang, Y., Hooper, D.C. Antimicrob. Agents Chemother. (2004) [Pubmed]

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