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Chemical Compound Review

CCRIS 689     4-amino-N-(5- chloroquinoxalin-2...

Synonyms: NCIMech_000335, SureCN6375915, CCG-35544, NSC-339004, AC1Q6UFH, ...
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Disease relevance of Chlorsulfaquinoxaline


High impact information on Chlorsulfaquinoxaline

  • Plasma for characterization of the pharmacokinetics of free and total CQS was obtained during and after the initial infusion and, when possible, during and after subsequent infusions of CQS if the dose had been reduced [2].
  • Mean peak plasma [CQS] and AUC increased with dose, with a suggestion that peak plasma [CQS] plateaued at higher doses [2].


  1. A phase II study of chloroquinoxaline sulfonamide (CQS) in patients with metastatic colorectal carcinoma (MCRC). Bekaii-Saab, T.S., Mortazavi, A., Hicks, L.G., Zalupski, M., Pelley, R.J., Chan, K.K., Kraut, E.H. Investigational new drugs. (2006) [Pubmed]
  2. Phase I trial of chloroguinoxaline sulfonamide, with correlation of its pharmacokinetics and pharmacodynamics. Conley, B.A., O'Hara, S., Wu, S., Melink, T.J., Parnes, H., Pardoe, E., Egorin, M.J., Van Echo, D.A. Cancer Chemother. Pharmacol. (1995) [Pubmed]
  3. Phase II trial of chloroquinoxaline sulfonamide (CQS) in patients with stage III and IV non-small-cell lung cancer. Miller, V.A., Rigas, J.R., Tong, W.P., Reid, J.R., Pisters, K.M., Grant, S.C., Heelan, R.T., Kris, M.G. Cancer Chemother. Pharmacol. (1997) [Pubmed]
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