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Chemical Compound Review:

SureCN42864 (4aR,5R,6aR,6aS,6bR,8aR,10S,12 aS,14bR)-5...

Synonyms: CHEMBL230128, KST-1A5313, Ambap510-30-5, AC1L2JMV, AR-1A4959, ...

Lee, K.W. et al., Bader, G. et al., Konoshima, T. et al., Tong, X. et al., Tong, X. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of C08942

Derivatives of echinocystic acid [8], the aglycone of compound 1, were also prepared and evaluated for inhibitory activity against HIV replication [1].
Beta-D-xylopyranosyl-(1-->3)-beta-D-glucuronopyranosyl echinocystic acid isolated from the roots of Codonopsis lanceolata induces caspase-dependent apoptosis in human acute promyelocytic leukemia HL-60 cells [2].

High impact information on C08942

Molecular mechanisms of echinocystic acid-induced apoptosis in HepG2 cells [3].
In the case of echinocystic acid glycosides the acylglycosidic carbohydrate sequence 1-arabinose-2 <-- 1-rhamnose-4 <-- 1-glucose seems to influence the rate of the cytotoxic effects [4].

Anatomical context of C08942

Echinocystic acid induces apoptosis in HL-60 cells through mitochondria-mediated death pathway [5].

References

Anti-AIDS agents, 21. Triterpenoid saponins as anti-HIV principles from fruits of Gleditsia japonica and Gymnocladus chinensis, and a structure-activity correlation. Konoshima, T., Yasuda, I., Kashiwada, Y., Cosentino, L.M., Lee, K.H. J. Nat. Prod. (1995) [Pubmed]
Beta-D-xylopyranosyl-(1-->3)-beta-D-glucuronopyranosyl echinocystic acid isolated from the roots of Codonopsis lanceolata induces caspase-dependent apoptosis in human acute promyelocytic leukemia HL-60 cells. Lee, K.W., Jung, H.J., Park, H.J., Kim, D.G., Lee, J.Y., Lee, K.T. Biol. Pharm. Bull. (2005) [Pubmed]
Molecular mechanisms of echinocystic acid-induced apoptosis in HepG2 cells. Tong, X., Lin, S., Fujii, M., Hou, D.X. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
Cytotoxicity of triterpenoid saponins. Part 1: Activities against tumor cells in vitro and hemolytical index. Bader, G., Plohmann, B., Hiller, K., Franz, G. Die Pharmazie. (1996) [Pubmed]
Echinocystic acid induces apoptosis in HL-60 cells through mitochondria-mediated death pathway. Tong, X., Lin, S., Fujii, M., Hou, D.X. Cancer Lett. (2004) [Pubmed]

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