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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Carbohydrate Sequence

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Disease relevance of Carbohydrate Sequence


High impact information on Carbohydrate Sequence

  • The most significant finding was the presence of cell surface Neu5Ac alpha 2-6Gal residues as detected with the Sambucus nigra lectin on EAT-c and EAT-c/m cells, whereas EAT-wt cells contained little or none of such carbohydrate sequences [3].
  • Results obtained with fibronectin are consistent with a model in which high-affinity binding (Kd approximately 34 nM) is mediated through the recognition of specific carbohydrate sequences [4].
  • Both of these precursors appear to have an intracellular half-life of at least 1 hr and to contain the mannose core but not the terminal carbohydrate sequences [5].
  • Since GC contains 60% carbohydrate by weight, we assessed the role of carbohydrate sequences on its interaction with antibody 6D1 and vWF [6].
  • IgM antibodies in the sera from 2 other patients reacted with GD1a and GT1b gangliosides, which have a shared terminal carbohydrate sequence [7].

Biological context of Carbohydrate Sequence


Anatomical context of Carbohydrate Sequence


Associations of Carbohydrate Sequence with chemical compounds


Gene context of Carbohydrate Sequence


  1. The pili of Pseudomonas aeruginosa strains PAK and PAO bind specifically to the carbohydrate sequence beta GalNAc(1-4)beta Gal found in glycosphingolipids asialo-GM1 and asialo-GM2. Sheth, H.B., Lee, K.K., Wong, W.Y., Srivastava, G., Hindsgaul, O., Hodges, R.S., Paranchych, W., Irvin, R.T. Mol. Microbiol. (1994) [Pubmed]
  2. Oligosaccharide moieties of the glycoprotein of vesicular stomatitis virus. Moyer, S.A., Tsang, J.M., Atkinson, P.H., Summers, D.F. J. Virol. (1976) [Pubmed]
  3. Differential expression of cell surface sialoglycoconjugates on wild-type and cultured Ehrlich tumor cells as revealed by quantitative lectin-gold ultrastructural cytochemistry. Roth, J., Li, W.P., Knibbs, R.N., MacCallum, D.K., Song, Z., Goldstein, I.J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  4. Analysis of affinity and structural selectivity in the binding of proteins to glycosaminoglycans: development of a sensitive electrophoretic approach. Lee, M.K., Lander, A.D. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  5. Synthesis and processing of human chorionic gonadotropin subunits in cultured choriocarcinoma cells. Ruddon, R.W., Hanson, C.A., Addison, N.J. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  6. Partial characterization of a binding site for von Willebrand factor on glycocalicin. Michelson, A.D., Loscalzo, J., Melnick, B., Coller, B.S., Handin, R.I. Blood (1986) [Pubmed]
  7. Serum antibodies to gangliosides in Guillain-Barré syndrome. Ilyas, A.A., Willison, H.J., Quarles, R.H., Jungalwala, F.B., Cornblath, D.R., Trapp, B.D., Griffin, D.E., Griffin, J.W., McKhann, G.M. Ann. Neurol. (1988) [Pubmed]
  8. Structure of the lipopolysaccharide core region of Hafnia alvei strains 1185 and 1204. Kübler, J., Katzenellenbogen, E., Gamian, A., Bogulska, M., Ejchart, A., Romanowska, E. Carbohydr. Res. (2000) [Pubmed]
  9. In vitro evidence that carbohydrate moieties derived from uromodulin, an 85,000 dalton immunosuppressive glycoprotein isolated from human pregnancy urine, are immunosuppressive in the absence of intact protein. Muchmore, A.V., Shifrin, S., Decker, J.M. J. Immunol. (1987) [Pubmed]
  10. Absence of a stratum corneum antigen in disorders of epidermal cell proliferation: detection with an anti-ganglioside GM3 antibody. Paller, A.S., Siegel, J.N., Spalding, D.E., Bremer, E.G. J. Invest. Dermatol. (1989) [Pubmed]
  11. Glycosyl transferases of baby-hamster-kidney (BHK) cells and ricin-resistant mutants. N-glycan biosynthesis. Vischer, P., Hughes, R.C. Eur. J. Biochem. (1981) [Pubmed]
  12. Sendai virus receptor: proposed recognition structure based on binding to plastic-adsorbed gangliosides. Holmgren, J., Svennerholm, L., Elwing, H., Fredman, P., Strannegård, O. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  13. Structure determination of the octa- and decasaccharide sequences isolated from the carbohydrate-protein linkage region of porcine intestinal heparin. Sugahara, K., Tsuda, H., Yoshida, K., Yamada, S., de Beer, T., Vliegenthart, J.F. J. Biol. Chem. (1995) [Pubmed]
  14. Evidence for lipid-protein interactions in the attachment of antigens to a low-density membrane fraction isolated from Trypanosoma rhodesiense. McLaughlin, J. Infect. Immun. (1984) [Pubmed]
  15. Heparan sulfate proteoglycans. Essential co-factors in receptor-mediated processes with relevance to the biology of the vascular wall. David, G., Danneels, A., Duerr, J., Grootjans, J., Mertens, G., Nackaerts, K., Romaris, M., Schrurs, B., Steinfeld, R., Vekemans, S. Atherosclerosis (1995) [Pubmed]
  16. Characterization of the oligosaccharides associated with the human ovarian tumor marker CA125. Kui Wong, N., Easton, R.L., Panico, M., Sutton-Smith, M., Morrison, J.C., Lattanzio, F.A., Morris, H.R., Clark, G.F., Dell, A., Patankar, M.S. J. Biol. Chem. (2003) [Pubmed]
  17. cDNA, amino acid and carbohydrate sequence of barley seed-specific peroxidase BP 1. Johansson, A., Rasmussen, S.K., Harthill, J.E., Welinder, K.G. Plant Mol. Biol. (1992) [Pubmed]
  18. Fibroblast growth factors share binding sites in heparan sulphate. Kreuger, J., Jemth, P., Sanders-Lindberg, E., Eliahu, L., Ron, D., Basilico, C., Salmivirta, M., Lindahl, U. Biochem. J. (2005) [Pubmed]
  19. Pregnancy-associated changes in the glycosylation of tamm-horsfall glycoprotein. Expression of sialyl Lewis(x) sequences on core 2 type O-glycans derived from uromodulin. Easton, R.L., Patankar, M.S., Clark, G.F., Morris, H.R., Dell, A. J. Biol. Chem. (2000) [Pubmed]
  20. SSEA-1 is a specific marker for the spinal sensory neuron lineage in the quail embryo and in neural crest cell cultures. Sieber-Blum, M. Dev. Biol. (1989) [Pubmed]
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