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Chemical Compound Review

SureCN95324     1-[4-(2,5-dioxopyrrol-1- yl)phenyl]pyrrole...

Synonyms: CHEMBL576594, P23989_ALDRICH, AG-E-98394, AG-J-58149, ACMC-209hvr, ...
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High impact information on NSC 81257

  • In the present study, we tested this prediction by using either unmodified S-1 or S-1 chemically modified with N,N'-p-phenylenedimaleimide (pPDM X S-1) so that functionally it acts like S-1.ATP, although it does not hydrolyze ATP [1].
  • Using the pyrene-labeled Mg forms of yeast and muscle actins, we demonstrate that under low ionic strength conditions, P.IB causes formation of filamentous actin assemblies, although they, unlike F-actin, cannot be internally cross-linked with N,N'-4-phenylenedimaleimide (PDM) [2].
  • Rate constants for the reactions of Cys-697 and Cys-707 of skeletal muscle myosin subfragment 1 (S1) with N,N'-p-phenylenedimaleimide (pPDM) and its monofunctional analog phenylmaleimide (PM) were measured for S1 and S1 bound to nucleotides and/or actin [3].
  • NANDP was trapped in nearly stoichiometric amounts at the active site by cross-linking SH1 and SH2 with N,N'-p-phenylenedimaleimide (pPDM) or by chelation with cobalt (III) phenanthroline [Wells, J., & Yount, R. (1979) Proc. Natl. Acad. Sci. U.S.A. 76, 4966] [4].
  • The effect of N,N'-p-phenylenedimaleimide (PMD) on deoxygenation-induced K loss in sickle erythrocytes [5].

Analytical, diagnostic and therapeutic context of NSC 81257


  1. Regulation of actomyosin ATPase activity by troponin-tropomyosin: effect of the binding of the myosin subfragment 1 (S-1).ATP complex. Greene, L.E., Williams, D.L., Eisenberg, E. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  2. Interaction of the gonococcal porin P.IB with G- and F-actin. Wen, K.K., Giardina, P.C., Blake, M.S., Edwards, J., Apicella, M.A., Rubenstein, P.A. Biochemistry (2000) [Pubmed]
  3. Kinetic investigation of the ligand dependence of rabbit skeletal muscle myosin subfragment 1 Cys-697 and Cys-707 reactivities. Polosukhina, K., Highsmith, S. Biochemistry (1997) [Pubmed]
  4. 2-[(4-Azido-2-nitrophenyl)amino]ethyl triphosphate, a novel chromophoric and photoaffinity analogue of ATP. Synthesis, characterization, and interaction with myosin subfragment 1. Nakamaye, K.L., Wells, J.A., Bridenbaugh, R.L., Okamoto, Y., Yount, R.G. Biochemistry (1985) [Pubmed]
  5. The effect of N,N'-p-phenylenedimaleimide (PMD) on deoxygenation-induced K loss in sickle erythrocytes. Wall, S.N., Berkowitz, L.R. Am. J. Med. Sci. (1987) [Pubmed]
  6. Changes in the thermal unfolding of p-phenylenedimaleimide-modified myosin subfragment 1 induced by its 'weak' binding to F-actin. Kaspieva, O.V., Nikolaeva, O.P., Orlov, V.N., Ponomarev, M.A., Drachev, V.A., Levitsky, D.I. FEBS Lett. (2001) [Pubmed]
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