Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

sFtHCQVILimKP@ 4-iodo-1H-pyrazole

Synonyms: zlchem 55, PubChem13295, AMTH001, SureCN71959, ACMC-1CSZW, ...

Hurley, T.D. et al., Fiala, E.S. et al.

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High impact information on PYZ

A naturally occurring variant of beta 1 alcohol dehydrogenase, found in approximately 50% of the Asian population, possesses a His at position 47 (beta 2 or beta 47H) and was crystallized in a complex with NAD+ and the inhibitor 4-iodopyrazole [1].
The metabolism of MAM by rat liver microsomes is sensitive to inhibition by carbon monoxide as well as to inhibition by 3-methylpyrazole (3-MeP) and 4-iodopyrazole (4-IP), with 4-IP being more potent in this respect than 3-MeP [2].

References

Structures of three human beta alcohol dehydrogenase variants. Correlations with their functional differences. Hurley, T.D., Bosron, W.F., Stone, C.L., Amzel, L.M. J. Mol. Biol. (1994) [Pubmed]
Differential effects of 4-iodopyrazole and 3-methylpyrazole on the metabolic activation of methylazoxymethanol to a DNA methylating species by rat liver and rat colon mucosa in vivo. Fiala, E.S., Sohn, O.S., Puz, C., Czerniak, R. J. Cancer Res. Clin. Oncol. (1987) [Pubmed]

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