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Chemical Compound Review

Valinol     2-amino-3-methyl-butan-1-ol

Synonyms: DL-Valinol, AG-L-63364, ACMC-2097ey, ACMC-209dq4, ACMC-209f79, ...
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Disease relevance of Valinol

  • The binding of 10 isomeric alpha-amino-heptanoic acids, of two isomeric alpha-amino-octanoic acids, of isoleucinol and valinol, and of various alpha-hydroxy acids to isoleucyl-tRNA synthetase from Escherichia coli MRE 600 has been investigated by an ultracentrifuge method [1].

High impact information on Valinol

  • TVs generally have molecular weights of approximately 1100-1200 Da, and are characterized by an acetylated N-terminus, the presence of an aminoalcohol, e.g. leucinol, isoleucinol or valinol, at the C-terminus, and eleven residues including three alpha-aminoisobutyric acids in the molecule [2].
  • The structure of L-valinol [(S)-(+)-2-amino-3-methylbutan-1-ol or hydroxylated L-valine], C(5)H(13)NO, has been determined at 100 K by single-crystal X-ray diffraction [3].


  1. Influence of side-chain structure of aliphatic amino acids on binding to isoleucyl-tRNA synthetase from Escherichia coli MRE 600. Flossdorf, J., Prätorius, H.J., Kula, M.R. Eur. J. Biochem. (1976) [Pubmed]
  2. Fungal metabolites. XIX. Structural elucidation of channel-forming peptides, trichorovins-I-XIV, from the fungus Trichoderma viride. Wada, S., Iida, A., Akimoto, N., Kanai, M., Toyama, N., Fujita, T. Chem. Pharm. Bull. (1995) [Pubmed]
  3. Invariom-model refinement of L-valinol. Dittrich, B., Munshi, P., Spackman, M.A. Acta crystallographica. Section C, Crystal structure communications (2006) [Pubmed]
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