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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Molecular Weight

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Disease relevance of Molecular Weight


Psychiatry related information on Molecular Weight


High impact information on Molecular Weight


Chemical compound and disease context of Molecular Weight


Biological context of Molecular Weight

  • These results on box9 mutants combined with results on box7 mutants suggest that an 14-encoded "maturase" protein (apparent molecular weight, 27,000) is cleaved off a precursor protein (apparent molecular weight, 55,000) encoded by exon sequences B1 to B4 and the intron open reading frame [21].
  • Analysis of the rp 51 plasmid transcripts reveals that the temperature-induced higher molecular weight transcripts differ from the mature rp 51 mRNA by the presence of an intron [22].
  • Forward and reverse mutations affecting the kinetics and apparent molecular weight of mammalian HGPRT [23].
  • Ultraviolet irradiation of the membrane-attached chromosomes causes the formation of a stable complex between two inner membrane proteins (molecular weight 80,000 and 56,000 daltons) and 5-bromodeoxyuridine (BrdU)-substituted DNA [24].
  • The protein eluted from the enhancer sequence-specific DNA affinity column showed a strong inducing activity for the HIG1 gene, and the molecular weight of a predominant protein was 96 kd [25].

Anatomical context of Molecular Weight


Associations of Molecular Weight with chemical compounds

  • The virus codes for three species having apparent molecular weights of 90,000, 60,000 and 22,000 daltons, as determined by polyacrylamide gel electrophoresis (90K, 60K and 22k) [31].
  • Covalent 32PO4-labeling of the alkaline phosphatases and polyacrylamide gel electrophoresis in sodium dodecylsulfate was also used to compare the subunit molecular weights of the enzymes [32].
  • Several laboratories have reported synthesis of proteins with similar molecular weights in cells subjected to conditions that alter glucose metabolism, and we speculate that these proteins may be associated with a hexose transport system [33].
  • Fractionation of DNA by the procedure of Hirt (1967) as well as by sedimentation through alkaline sucrose suggests that about two thirds of the viral DNA is associated with high molecular weight cell DNA [34].
  • Triton-extracted FC-1 exhibited a molecular weight of approximately 500,000, and a 60,000 dalton protein was immunoprecipitated from 35S-methionine-labeled cells [35].

Gene context of Molecular Weight

  • Secretion is blocked at the post-Golgi stage within 5 min of a shift of sec4-8 cells from 25 degrees C to 37 degrees C. Analysis of SEC4 predicts a protein product of 23.5 kd molecular weight that shares 32% homology with ras proteins and is essential for growth [36].
  • Analysis of size-fractionated mRNA from a SUC2 strain has shown that three mature, catabolite-repressible mRNA species direct the in vitro synthesis of three invertase polypeptides that have differing molecular weights [37].
  • Several species related to Drosophila melanogaster have two loci containing sequences which code for the major heat-shock protein of molecular weight 70,000 (hsp70) [38].
  • A genetic deficiency of the fifth (C5) component of complement1-3, a serum glycoprotein of molecular weight (MW) 220,000 (ref. 4), has been found in 39% of inbred strains of mice3 [39].
  • An open reading frame of 1785 nucleotides in the complementary DNA corresponded to a polypeptide of 595 amino acids and a molecular weight of 66,200, which is in good agreement with published molecular weight values of 65,000 to 70,000 for the estrogen receptor [40].

Analytical, diagnostic and therapeutic context of Molecular Weight


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  2. A unique glycoprotein containing GR-mouse mammary tumor virus peptides and additional peptides unrelated to viral structural proteins. Anderson, S.J., Naso, R.B. Cell (1980) [Pubmed]
  3. Familial hyperglucagonemia--an autosomal dominant disorder. Boden, G., Owen, O.E. N. Engl. J. Med. (1977) [Pubmed]
  4. Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3. Plowman, G.D., Brown, J.P., Enns, C.A., Schröder, J., Nikinmaa, B., Sussman, H.H., Hellström, K.E., Hellström, I. Nature (1983) [Pubmed]
  5. Acceptors for botulinum neurotoxin reside on motor nerve terminals and mediate its internalization. Dolly, J.O., Black, J., Williams, R.S., Melling, J. Nature (1984) [Pubmed]
  6. Hereditary cerebral hemorrhage with amyloidosis--Dutch type: its importance for Alzheimer research. Haan, J., Hardy, J.A., Roos, R.A. Trends Neurosci. (1991) [Pubmed]
  7. Treatment of acute venous thromboembolism with low molecular weight heparin (Fragmin). Results of a double-blind randomized study. Albada, J., Nieuwenhuis, H.K., Sixma, J.J. Circulation (1989) [Pubmed]
  8. Calpain-dependent endoproteolytic cleavage of PrPSc modulates scrapie prion propagation. Yadavalli, R., Guttmann, R.P., Seward, T., Centers, A.P., Williamson, R.A., Telling, G.C. J. Biol. Chem. (2004) [Pubmed]
  9. CuZn-SOD deficiency, rather than overexpression, is associated with enhanced recovery and attenuated activation of NF-kappaB after brain trauma in mice. Beni, S.M., Tsenter, J., Alexandrovich, A.G., Galron-Krool, N., Barzilai, A., Kohen, R., Grigoriadis, N., Simeonidou, C., Shohami, E. J. Cereb. Blood Flow Metab. (2006) [Pubmed]
  10. Molecular design of hybrid tumour necrosis factor alpha with polyethylene glycol increases its anti-tumour potency. Tsutsumi, Y., Kihira, T., Tsunoda, S., Kanamori, T., Nakagawa, S., Mayumi, T. Br. J. Cancer (1995) [Pubmed]
  11. Selenium-dependent enzymes. Stadtman, T.C. Annu. Rev. Biochem. (1980) [Pubmed]
  12. Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo. Scherzinger, E., Lurz, R., Turmaine, M., Mangiarini, L., Hollenbach, B., Hasenbank, R., Bates, G.P., Davies, S.W., Lehrach, H., Wanker, E.E. Cell (1997) [Pubmed]
  13. A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast. Thompson, C.M., Koleske, A.J., Chao, D.M., Young, R.A. Cell (1993) [Pubmed]
  14. Disruption of the single tropomyosin gene in yeast results in the disappearance of actin cables from the cytoskeleton. Liu, H.P., Bretscher, A. Cell (1989) [Pubmed]
  15. Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation. Pingel, J.T., Thomas, M.L. Cell (1989) [Pubmed]
  16. Spiroplasmavirus citri 3: propagation, purification, proteins, and nucleic acid. Cole, R.M., Mitchell, W.O., Garon, C.F. Science (1977) [Pubmed]
  17. Structural analysis and immunogenicity of Pseudomonas aeruginosa immunotype 2 high molecular weight polysaccharide. Pier, G.B., Bennett, S.E. J. Clin. Invest. (1986) [Pubmed]
  18. Induction of differentiation of Friend murine erythroleukemia cells by poly-L-lysine and daunorubicin-poly-L-lysine conjugate. Supino, R., Gibelli, N., Zunino, F. J. Natl. Cancer Inst. (1986) [Pubmed]
  19. Low molecular weight iron and the oxygen paradox in isolated rat hearts. Voogd, A., Sluiter, W., van Eijk, H.G., Koster, J.F. J. Clin. Invest. (1992) [Pubmed]
  20. Prostanoid inhibition of canine parietal cells: mediation by the inhibitory guanosine triphosphate-binding protein of adenylate cyclase. Chen, M.C., Amirian, D.A., Toomey, M., Sanders, M.J., Soll, A.H. Gastroenterology (1988) [Pubmed]
  21. Expression of the split gene cob in yeast: evidence for a precursor of a "maturase" protein translated from intron 4 and preceding exons. Weiss-Brummer, B., Rödel, G., Schweyen, R.J., Kaudewitz, F. Cell (1982) [Pubmed]
  22. The effect of temperature-sensitive RNA mutants on the transcription products from cloned ribosomal protein genes of yeast. Rosbash, M., Harris, P.K., Woolford, J.L., Teem, J.L. Cell (1981) [Pubmed]
  23. Forward and reverse mutations affecting the kinetics and apparent molecular weight of mammalian HGPRT. Fenwick, R.G., Sawyer, T.H., Kruh, G.D., Astrin, K.H., Caskey, C.T. Cell (1977) [Pubmed]
  24. Association of the folded chromosome with the cell envelope of E. coli: characterization of the proteins at the DNA-membrane attachment site. Portalier, R., Worcel, A. Cell (1976) [Pubmed]
  25. Purification of a nuclear trans-acting factor involved in the regulated transcription of a human immunoglobulin heavy chain gene. Araki, K., Maeda, H., Wang, J., Kitamura, D., Watanabe, T. Cell (1988) [Pubmed]
  26. Coexpression of a PDGF-like growth factor and PDGF receptors in a human osteosarcoma cell line: implications for autocrine receptor activation. Betsholtz, C., Westermark, B., Ek, B., Heldin, C.H. Cell (1984) [Pubmed]
  27. Ecdysteroid-inducible polypeptides in a Drosophila cell line. Savakis, C., Demetri, G., Cherbas, P. Cell (1980) [Pubmed]
  28. Structural characterization of the TAP molecule: a phosphatidylinositol-linked glycoprotein distinct from the T cell receptor/T3 complex and Thy-1. Reiser, H., Oettgen, H., Yeh, E.T., Terhorst, C., Low, M.G., Benacerraf, B., Rock, K.L. Cell (1986) [Pubmed]
  29. Base-pairing interactions between small nuclear RNAs and nuclear RNA precursors as revealed by psoralen cross-linking in vivo. Calvet, J.P., Pederson, T. Cell (1981) [Pubmed]
  30. Cell surface protein decreases microvilli and ruffles on transformed mouse and chick cells. Yamada, K.M., Ohanian, S.H., Pastan, I. Cell (1976) [Pubmed]
  31. Characterization of T antigens in polyoma-infected and transformed cells. Hutchinson, M.A., Hunter, T., Eckhart, W. Cell (1978) [Pubmed]
  32. Characterization of two different alkaline phosphatases in mouse teratoma: partial purification, electrophoretic, and histochemical studies. Wada, H.G., VandenBerg, S.R., Sussman, H.H., Grove, W.E., Herman, M.M. Cell (1976) [Pubmed]
  33. The effect of amino acid analogues and heat shock on gene expression in chicken embryo fibroblasts. Kelley, P.M., Schlesinger, M.J. Cell (1978) [Pubmed]
  34. Mouse mammary tumor virus DNA in infected rat cells: characterization of unintegrated forms. Ringold, G.M., Yamamoto, K.R., Shank, P.R., Varmus, H.E. Cell (1977) [Pubmed]
  35. New surface component of fibroblast's focal contacts identified by a monoclonal antibody. Oesch, B., Birchmeier, W. Cell (1982) [Pubmed]
  36. A ras-like protein is required for a post-Golgi event in yeast secretion. Salminen, A., Novick, P.J. Cell (1987) [Pubmed]
  37. Distinct repressible mRNAs for cytoplasmic and secreted yeast invertase are encoded by a single gene. Perlman, D., Halvorson, H.O. Cell (1981) [Pubmed]
  38. Evolution of the 87A and 87C heat-shock loci in Drosophila. Leigh Brown, A.J., Ish-Horowicz, D. Nature (1981) [Pubmed]
  39. Genetic defect in secretion of complement C5 in mice. Ooi, Y.M., Colten, H.R. Nature (1979) [Pubmed]
  40. Sequence and expression of human estrogen receptor complementary DNA. Greene, G.L., Gilna, P., Waterfield, M., Baker, A., Hort, Y., Shine, J. Science (1986) [Pubmed]
  41. Soluble acidic complexes containing histones H3 and H4 in nuclei of Xenopus laevis oocytes. Kleinschmidt, J.A., Franke, W.W. Cell (1982) [Pubmed]
  42. Muscle proteolysis induced by a circulating peptide in patients with sepsis or trauma. Clowes, G.H., George, B.C., Villee, C.A., Saravis, C.A. N. Engl. J. Med. (1983) [Pubmed]
  43. Antibodies to a scrapie prion protein. Bendheim, P.E., Barry, R.A., DeArmond, S.J., Stites, D.P., Prusiner, S.B. Nature (1984) [Pubmed]
  44. Human HLA gene segment isolated by hybridization with mouse H-2 cDNA probes. Jordan, B.R., Bregegere, F., Kourilsky, P. Nature (1981) [Pubmed]
  45. Low molecular weight heparin: a critical analysis of clinical trials. Green, D., Hirsh, J., Heit, J., Prins, M., Davidson, B., Lensing, A.W. Pharmacol. Rev. (1994) [Pubmed]
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