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Chemical Compound Review:

iminoaspartate 2-iminobutanedioic acid

Synonyms: iminosuccinate, AG-H-17028, CHEBI:50616, HMDB01131, CTK5E6417, ...

Mortarino, M. et al., Bossi, R.T. et al., Nasu, S. et al.

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Disease relevance of Iminoaspartic acid

Replacement of the B protein requirement of the E. coli quinolinate synthetase system by chemically-generated iminoaspartate [1].

High impact information on Iminoaspartic acid

L-Aspartate oxidase (Laspo) catalyzes the conversion of L-Asp to iminoaspartate, the first step in the de novo biosynthesis of NAD(+) [2].
L-Aspartate oxidase was subjected to product inhibition since iminoaspartate, which results from the oxidation of L-aspartate, binds to the enzyme with a dissociation constant (Kd) equal to 1.4 microM [3].

References

Replacement of the B protein requirement of the E. coli quinolinate synthetase system by chemically-generated iminoaspartate. Nasu, S., Gholson, R.K. Biochem. Biophys. Res. Commun. (1981) [Pubmed]
Structure of FAD-bound L-aspartate oxidase: insight into substrate specificity and catalysis. Bossi, R.T., Negri, A., Tedeschi, G., Mattevi, A. Biochemistry (2002) [Pubmed]
L-aspartate oxidase from Escherichia coli. I. Characterization of coenzyme binding and product inhibition. Mortarino, M., Negri, A., Tedeschi, G., Simonic, T., Duga, S., Gassen, H.G., Ronchi, S. Eur. J. Biochem. (1996) [Pubmed]

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