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Gene Review

nadB  -  quinolinate synthase, L-aspartate oxidase...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2572, JW2558, nic, nicB
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Disease relevance of nadB


High impact information on nadB


Chemical compound and disease context of nadB


Biological context of nadB


Associations of nadB with chemical compounds


Other interactions of nadB

  • Adjacent to cooA are two genes, nadB and nadC, with predicted products similar to proteins in other bacteria that catalyze reactions in the de novo synthesis of NAD.(ABSTRACT TRUNCATED AT 250 WORDS)[13]
  • We describe the identification of the Yersinia enterocolitica rpoE gene, which encodes the alternative sigma factor sigmaE, and the divergently transcribed nadB gene, as genes that are expressed during infection of mice [3].

Analytical, diagnostic and therapeutic context of nadB


  1. Molecular biology of pyridine nucleotide biosynthesis in Escherichia coli. Cloning and characterization of quinolinate synthesis genes nadA and nadB. Flachmann, R., Kunz, N., Seifert, J., Gütlich, M., Wientjes, F.J., Läufer, A., Gassen, H.G. Eur. J. Biochem. (1988) [Pubmed]
  2. Expression of the E. coli nadB gene and characterization of the gene product L-aspartate oxidase. Seifert, J., Kunz, N., Flachmann, R., Läufer, A., Jany, K.D., Gassen, H.G. Biol. Chem. Hoppe-Seyler (1990) [Pubmed]
  3. Identification of rpoE and nadB as host responsive elements of Yersinia enterocolitica. Heusipp, G., Schmidt, M.A., Miller, V.L. FEMS Microbiol. Lett. (2003) [Pubmed]
  4. L-Aspartate oxidase, a newly discovered enzyme of Escherichia coli, is the B protein of quinolinate synthetase. Nasu, S., Wicks, F.D., Gholson, R.K. J. Biol. Chem. (1982) [Pubmed]
  5. Nicking activity of TrwC directed against the origin of transfer of the IncW plasmid R388. Llosa, M., Grandoso, G., de la Cruz, F. J. Mol. Biol. (1995) [Pubmed]
  6. Probing the active site of L-aspartate oxidase by site-directed mutagenesis: role of basic residues in fumarate reduction. Tedeschi, G., Ronchi, S., Simonic, T., Treu, C., Mattevi, A., Negri, A. Biochemistry (2001) [Pubmed]
  7. Redox potentials and quinone reductase activity of L-aspartate oxidase from Escherichia coli. Tedeschi, G., Zetta, L., Negri, A., Mortarino, M., Ceciliani, F., Ronchi, S. Biochemistry (1997) [Pubmed]
  8. Quinolinate synthetase, an iron-sulfur enzyme in NAD biosynthesis. Ollagnier-de Choudens, S., Loiseau, L., Sanakis, Y., Barras, F., Fontecave, M. FEBS Lett. (2005) [Pubmed]
  9. L-aspartate oxidase from Escherichia coli. II. Interaction with C4 dicarboxylic acids and identification of a novel L-aspartate: fumarate oxidoreductase activity. Tedeschi, G., Negri, A., Mortarino, M., Ceciliani, F., Simonic, T., Faotto, L., Ronchi, S. Eur. J. Biochem. (1996) [Pubmed]
  10. Characterization of an efficient gene cloning strategy for Aspergillus niger based on an autonomously replicating plasmid: cloning of the nicB gene of A. niger. Verdoes, J.C., Punt, P.J., van der Berg, P., Debets, F., Stouthamer, A.H., van den Hondel, C.A. Gene (1994) [Pubmed]
  11. Structural characterization of l-aspartate oxidase and identification of an interdomain loop by limited proteolysis. Tedeschi, G., Negri, A., Ceciliani, F., Mattevi, A., Ronchi, S. Eur. J. Biochem. (1999) [Pubmed]
  12. L-aspartate oxidase from Escherichia coli. I. Characterization of coenzyme binding and product inhibition. Mortarino, M., Negri, A., Tedeschi, G., Simonic, T., Duga, S., Gassen, H.G., Ronchi, S. Eur. J. Biochem. (1996) [Pubmed]
  13. Carbon monoxide-induced activation of gene expression in Rhodospirillum rubrum requires the product of cooA, a member of the cyclic AMP receptor protein family of transcriptional regulators. Shelver, D., Kerby, R.L., He, Y., Roberts, G.P. J. Bacteriol. (1995) [Pubmed]
  14. Crystallization of L-aspartate oxidase, the first enzyme in the bacterial de novo biosynthesis of NAD. Bacchella, L., Lina, C., Todone, F., Negri, A., Tedeschi, G., Ronchi, S., Mattevi, A. Acta Crystallogr. D Biol. Crystallogr. (1999) [Pubmed]
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