Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

PubChem15118 anthracene-9,10-dicarbaldehyde

Synonyms: AG-G-75026, CHEBI:51295, ANW-58599, NSC-529667, AC1Q6QCI, ...

Foye, W.O. et al., Kuhn, J.G. et al.

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High impact information on NSC529667

The pharmacokinetics of bisantrene, 9,10-anthracenedicarboxaldehyde bis [4,5-dihydro-1 H-imidazol-2-yl) hydrazone) dihydrochloride were evaluated during a Phase I clinical investigation [1].

Analytical, diagnostic and therapeutic context of NSC529667

DNA-binding strengths of three anthracene-9,10-dicarboxaldehyde hydrazones were examined by spectral shifts of the drug-DNA combinations, spectral titration by Scatchard plots, elevation of DNA melting temperature during complexation and comparison of spectral shifts in the presence of DNA's having variable base contents [2].

References

Characterization of the pharmacokinetics of bisantrene (NSC-337766). Kuhn, J.G., Ludden, T.M., Myers, J.W., Von Hoff, D.D. Investigational new drugs. (1983) [Pubmed]
DNA-binding abilities of bisguanylhydrazones of anthracene-9,10-dicarboxaldehyde. Foye, W.O., Karnik, P.S., Sengupta, S.K. Anticancer Drug Des. (1986) [Pubmed]

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