Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Cyclonol 3,3,5-trimethylcyclohexan-1-ol

Synonyms: Homomenthol, SureCN113337, NSC-4008, ACMC-1C9B3, AG-D-37300, ...

Heffron, F. et al., White, D.A. et al., Middleton, B. et al.

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High impact information on Cyclohexanol, 3,3,5-trimethyl-, (1R,5S)-rel-

The intact drug was required for its inhibitory action since neither of its hydrolysis products, trimethylcyclohexanol and mandelic acid, caused any inhibition even at high concentrations [1].
There was no direct inhibition of HMGCoA reductase by trimethylcyclohexanol when added to the assay system in vitro [2].
2. Cultured rat hepatocytes accumulated trimethylcyclohexanol rapidly and excreted its glucuronide into the culture medium [3].

References

The inhibition of cholesterol esterification by cyclandelate in transformed mouse macrophages. Heffron, F., Middleton, B., White, D.A. Biochem. Pharmacol. (1993) [Pubmed]
The inhibition of hepatic S-3-hydroxy-3-methylglutaryl-CoA reductase by 3,3,5-trimethylcyclohexanol and its mandelic acid ester, cyclandelate. Middleton, B., Middleton, A., Miciak, A., White, D.A., Bell, G.D. Biochem. Pharmacol. (1983) [Pubmed]
Chemical synthesis of dual-radiolabelled cyclandelate and its metabolism in rat hepatocytes and mouse J774 cells. White, D.A., Heffron, F., Miciak, A., Middleton, B., Knights, S., Knight, D. Xenobiotica (1990) [Pubmed]

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