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Gene Review

Hmgcr  -  3-hydroxy-3-methylglutaryl-CoA reductase

Rattus norvegicus

Synonyms: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase
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  1. Modified HMG-CoA reductase and LDLr regulation is deeply involved in age-related hypercholesterolemia. Pallottini, V., Martini, C., Cavallini, G., Donati, A., Bergamini, E., Notarnicola, M., Caruso, M.G., Trentalance, A. J. Cell. Biochem. (2006) [Pubmed]
  2. Contribution of increased HMG-CoA reductase gene expression to hypercholesterolemia in experimental chronic renal failure. Chmielewski, M., Sucajtys, E., Swierczynski, J., Rutkowski, B., Bogusławski, W. Mol. Cell. Biochem. (2003) [Pubmed]
  3. Differential translational effects of myristic acid and eicosapentaenoic acid on 3-hydroxy-3-methylglutaryl-CoA reductase from Reuber H35 hepatoma cells. García-Pelayo, M.C., García-Peregrín, E., Martínez-Cayuela, M. Exp. Biol. Med. (Maywood) (2004) [Pubmed]
  4. Regulation of early cholesterol biosynthesis in rat liver: effects of sterols, bile acids, lovastatin, and BM 15.766 on 3-hydroxy-3-methylglutaryl coenzyme A synthase and acetoacetyl coenzyme A thiolase activities. Honda, A., Salen, G., Nguyen, L.B., Xu, G., Tint, G.S., Batta, A.K., Shefer, S. Hepatology (1998) [Pubmed]
  5. Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in Morris hepatoma 7800 after intravenous injection of mevalonic acid. George, R., Goldfarb, S. Cancer Res. (1980) [Pubmed]
  6. Blockade of HMG-CoA reductase activity causes changes in microtubule-stabilizing protein tau via suppression of geranylgeranylpyrophosphate formation: implications for Alzheimer's disease. Meske, V., Albert, F., Richter, D., Schwarze, J., Ohm, T.G. Eur. J. Neurosci. (2003) [Pubmed]
  7. Dietary modification of the distribution of 3-hydroxy-3-methylglutaryl coenzyme A reductase and sterol synthesizing activities in the rat small intestine. Sugano, M., Ide, T., Okamatsu, H., Fujisaki, Y., Takahara, H. J. Nutr. (1980) [Pubmed]
  8. Effect of type of diet and feeding status on modulation of hepatic HMG-CoA reductase in rats. Kelley, M.J., Story, J.A. Lipids (1985) [Pubmed]
  9. Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity. 1976. Endo, A., Kuroda, M., Tanzawa, K. Atherosclerosis. Supplements. (2004) [Pubmed]
  10. Growth hormone and bile acid synthesis. Key role for the activity of hepatic microsomal cholesterol 7alpha-hydroxylase in the rat. Rudling, M., Parini, P., Angelin, B. J. Clin. Invest. (1997) [Pubmed]
  11. Stimulation of rat hepatic low density lipoprotein receptors by glucagon. Evidence of a novel regulatory mechanism in vivo. Rudling, M., Angelin, B. J. Clin. Invest. (1993) [Pubmed]
  12. Lovastatin inhibits proliferation of rat mesangial cells. O'Donnell, M.P., Kasiske, B.L., Kim, Y., Atluru, D., Keane, W.F. J. Clin. Invest. (1993) [Pubmed]
  13. Regulation of rat biliary cholesterol secretion by agents that alter intrahepatic cholesterol metabolism. Evidence for a distinct biliary precursor pool. Stone, B.G., Erickson, S.K., Craig, W.Y., Cooper, A.D. J. Clin. Invest. (1985) [Pubmed]
  14. Regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase in minimal deviation hepatoma 7288C. Immunological measurements in hepatoma tissue culture cells. Beirne, O.R., Heller, R., Watson, J.A. J. Biol. Chem. (1977) [Pubmed]
  15. Effects of pravastatin on progression of glucose intolerance and cardiovascular remodeling in a type II diabetes model. Yu, Y., Ohmori, K., Chen, Y., Sato, C., Kiyomoto, H., Shinomiya, K., Takeuchi, H., Mizushige, K., Kohno, M. J. Am. Coll. Cardiol. (2004) [Pubmed]
  16. Role of mevalonate in regulation of cholesterol synthesis and 3-hydroxy-3-methylglutaryl coenzyme A reductase in cultured cells and their cytoplasts. Popják, G., Clarke, C.F., Hadley, C., Meenan, A. J. Lipid Res. (1985) [Pubmed]
  17. Effects of the combination of an angiotensin II antagonist with an HMG-CoA reductase inhibitor in experimental diabetes. Qin, J., Zhang, Z., Liu, J., Sun, L., Hu, L., Cooper, M.E., Cao, Z. Kidney Int. (2003) [Pubmed]
  18. Farnesol and geraniol chemopreventive activities during the initial phases of hepatocarcinogenesis involve similar actions on cell proliferation and DNA damage, but distinct actions on apoptosis, plasma cholesterol and HMGCoA reductase. Ong, T.P., Heidor, R., de Conti, A., Dagli, M.L., Moreno, F.S. Carcinogenesis (2006) [Pubmed]
  19. Phosphorylation and inactivation of HMG-CoA reductase at the AMP-activated protein kinase site in response to fructose treatment of isolated rat hepatocytes. Gillespie, J.G., Hardie, D.G. FEBS Lett. (1992) [Pubmed]
  20. Mechanisms underlying the impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in aged rat liver. Pallottini, V., Montanari, L., Cavallini, G., Bergamini, E., Gori, Z., Trentalance, A. Mech. Ageing Dev. (2004) [Pubmed]
  21. Regulation of acylcoenzyme A. Cholesterol acyltransferase and 3-hydroxy-3-methylglutaryl coenzyme A reductase activity by lipoproteins in the intestine of parabiont rats. Purdy, B.H., Field, F.J. J. Clin. Invest. (1984) [Pubmed]
  22. Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for enzyme degradation in the endoplasmic reticulum. Roitelman, J., Olender, E.H., Bar-Nun, S., Dunn, W.A., Simoni, R.D. J. Cell Biol. (1992) [Pubmed]
  23. 3-Hydroxy-3-methylglutaryl coenzyme A reductase localization in rat liver peroxisomes and microsomes of control and cholestyramine-treated animals: quantitative biochemical and immunoelectron microscopical analyses. Keller, G.A., Pazirandeh, M., Krisans, S. J. Cell Biol. (1986) [Pubmed]
  24. Purification of 3-hydroxy-3-methylglutaryl-coenzyme A reductase from rat liver. Kleinsek, D.A., Ranganathan, S., Porter, J.W. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  25. A rice bran oil diet increases LDL-receptor and HMG-CoA reductase mRNA expressions and insulin sensitivity in rats with streptozotocin/nicotinamide-induced type 2 diabetes. Chen, C.W., Cheng, H.H. J. Nutr. (2006) [Pubmed]
  26. Altered mRNA expression of hepatic lipogenic enzyme and PPARalpha in rats fed dietary levan from Zymomonas mobilis. Kang, S.A., Hong, K., Jang, K.H., Kim, Y.Y., Choue, R., Lim, Y. J. Nutr. Biochem. (2006) [Pubmed]
  27. Pravastatin, a HMG-CoA reductase inhibitor, blocks the cell cycle progression but not Ca2+ influx induced by IGF-I in FRTL-5 cells. Tada, H., Takada, K., Amino, N., Miyai, K. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  28. Insulin and glucagon modulate hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity by affecting immunoreactive protein levels. Ness, G.C., Zhao, Z., Wiggins, L. J. Biol. Chem. (1994) [Pubmed]
  29. Bile acid synthesis. VI. Regulation of cholesterol 7 alpha-hydroxylase by taurocholate and mevalonate. Pandak, W.M., Vlahcevic, Z.R., Chiang, J.Y., Heuman, D.M., Hylemon, P.B. J. Lipid Res. (1992) [Pubmed]
  30. Lack of correlation between 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and lovastatin resistance in nerve growth factor treated PC-12 cells. Marom, M., Ben-Baruch, G., Roitelman, J., Kloog, Y. Cell. Mol. Neurobiol. (1994) [Pubmed]
  31. HMG CoA reductase inhibitor suppresses the expression of tissue factor and plasminogen activator inhibitor-1 induced by angiotensin II in cultured rat aortic endothelial cells. Kunieda, Y., Nakagawa, K., Nishimura, H., Kato, H., Ukimura, N., Yano, S., Kawano, H., Kimura, S., Nakagawa, M., Tsuji, H. Thromb. Res. (2003) [Pubmed]
  32. Selective proteolytic processing of rat hepatic sterol regulatory element binding protein-1 (SREBP-1) and SREBP-2 during postnatal development. Botolin, D., Jump, D.B. J. Biol. Chem. (2003) [Pubmed]
  33. Activation of cyclin-dependent kinase 2 (Cdk2) in growth-stimulated rat astrocytes. Geranylgeranylated Rho small GTPase(s) are essential for the induction of cyclin E gene expression. Tanaka, T., Tatsuno, I., Noguchi, Y., Uchida, D., Oeda, T., Narumiya, S., Yasuda, T., Higashi, H., Kitagawa, M., Nakayama, K., Saito, Y., Hirai, A. J. Biol. Chem. (1998) [Pubmed]
  34. Effects of a fish oil-lard diet on rat plasma lipoproteins, liver FAS, and lipolytic enzymes. Benhizia, F., Hainault, I., Serougne, C., Lagrange, D., Hajduch, E., Guichard, C., Malewiak, M.I., Quignard-Boulangé, A., Lavau, M., Griglio, S. Am. J. Physiol. (1994) [Pubmed]
  35. The regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the isolated perfused rat liver. Cooper, A.D. J. Clin. Invest. (1976) [Pubmed]
  36. Hydroxymethylglutaryl-coenzyme A reductase-containing hepatocytes are distributed periportally in normal and mevinolin-treated rat livers. Singer, I.I., Kawka, D.W., Kazazis, D.M., Alberts, A.W., Chen, J.S., Huff, J.W., Ness, G.C. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  37. Lovastatin, an inhibitor of cholesterol synthesis, induces hydroxymethylglutaryl-coenzyme A reductase directly on membranes of expanded smooth endoplasmic reticulum in rat hepatocytes. Singer, I.I., Scott, S., Kazazis, D.M., Huff, J.W. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
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