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Chemical Compound Review

Uromaline     2-hydroxy-2-phenyl-ethanoic acid

Synonyms: SAMMA, PPCM, Amygdalic acid, MANDELIC ACID, CHEMBL1609, ...
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Disease relevance of alpha-Hydroxybenzeneacetic acid


Psychiatry related information on alpha-Hydroxybenzeneacetic acid


High impact information on alpha-Hydroxybenzeneacetic acid


Chemical compound and disease context of alpha-Hydroxybenzeneacetic acid


Biological context of alpha-Hydroxybenzeneacetic acid


Anatomical context of alpha-Hydroxybenzeneacetic acid

  • RESULT(S): Mandelic acid condensation polymer is not cytotoxic toward lactobacilli, microbial host cells, and spermatozoa [4].
  • Under conditions simulating heavy contamination (10(7)-10(8) cfu ml-1) however, only mandelic acid (1% w/v) eliminated the range of bacterial species commonly responsible for catheter-associated urinary tract infection [21].
  • Study of urinary mandelic acid concentration and peripheral nerve conduction among styrene workers [22].
  • Pre-operative work-up of this tumour should include measurements of urinary vanillyl mandelic acid and cathecholamine excretion, MRI and spiral CT of the abdomen and thorax [23].
  • Quantitative gas chromatographic mass spectrometric determination of mandelic acid in blood plasma. Comparison of deuterated and homologous internal standards [24].

Associations of alpha-Hydroxybenzeneacetic acid with other chemical compounds


Gene context of alpha-Hydroxybenzeneacetic acid

  • 3. Urinary vanillyl mandelic acid, catecholamines and metanephrines were also similar in the normotensive and hypertensive groups [29].
  • The most notable of the new analogues corresponds to the general formula D-Xaa-Pro-Arg-H, wherein Xaa means the acyl residue of mandelic acid (Man, 1), diphenyllactic acid (Dpl, 2), hexahydrophenyllactic acid (Hpl, 3), or hexahydromandelic acid (Hma, 4) [30].
  • After the disappearance of the initial tumours, periodic measurements of urinary vanillyl mandelic acid, homovanillic acid and serum neuron specific enolase values, and an 123I-MIBG scintigraphy were performed [31].
  • Both the (R)- and (S)-diastereoisomers of the M1 and M2 as well as the conventional biomarkers, mandelic acid (MA) and phenylglyoxylic acid (PGA) were measured in urinary samples [32].
  • Therefore, the biological monitoring by determination of urinary mandelic acid (MA) and phenylglyoxylic acid (PGA), hippuric acid (HA), and 2-, 3-, and 4-methylhippuric acids (2-, 3-, and 4-MHAs), the metabolites of STX, is required or at least recommended in case of workers exposed by these agents [33].

Analytical, diagnostic and therapeutic context of alpha-Hydroxybenzeneacetic acid


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  15. Determination of plasma concentrations of cyclandelate and mandelic acid in patients with generalized atherosclerotic vasculopathy treated with oral cyclandelate. Forconi, S., Cappelli, R., Guerrini, M., Volpi, L., Frigerio, C., Di Perri, T. J. Int. Med. Res. (1990) [Pubmed]
  16. The effect of modified fasting on blood pressure and sympathetic activity: a correlation? Koppeschaar, H.P., Meinders, A.E., Schwarz, F. International journal of obesity. (1983) [Pubmed]
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  18. Effects of low-level occupational exposure to styrene on color vision: dose relation with a urinary metabolite. Kishi, R., Eguchi, T., Yuasa, J., Katakura, Y., Arata, Y., Harabuchi, I., Kawai, T., Masuchi, A. Environmental research. (2001) [Pubmed]
  19. Urinary mandelic acid concentration after occupational exposure to styrene and its use as a biological exposure test. Engström, K., Härkönen, H., Kalliokoski, P., Rantanen, J. Scandinavian journal of work, environment & health. (1976) [Pubmed]
  20. Visual dysfunction among styrene-exposed workers. Campagna, D., Mergler, D., Huel, G., Bélanger, S., Truchon, G., Ostiguy, C., Drolet, D. Scandinavian journal of work, environment & health. (1995) [Pubmed]
  21. An assessment of antiseptic bladder washout solutions using a physical model of the catheterized bladder. King, J.B., Stickler, D.J. J. Hosp. Infect. (1991) [Pubmed]
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  23. Primary pheochromocytoma extending into the right atrium: report of a case and review of the literature. Hartgrink, H.H., Roelfsema, F., Tollenaar, R.A., Hiddema, P.A., Pijl, M.E., van de Velde, C.J. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. (2001) [Pubmed]
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  29. Choice of control groups in the appraisal of sympathetic nervous activity in essential hypertension. Jones, D.H., Hamilton, C.A., Reid, J.L. Clin. Sci. (1979) [Pubmed]
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  31. Utility of follow-up studies using meta-[123 I]iodobenzylguanidine scintigraphy for detecting recurrent neuroblastoma. Okuyama, C., Ushijima, Y., Kubota, T., Nakamura, T., Kikkawa, M., Nishimura, T. Nuclear medicine communications. (2002) [Pubmed]
  32. Urinary mercapturic acid diastereoisomers in rats subchronically exposed to styrene and ethanol. Coccini, T., Maestri, L., Robustelli della Cuna, F.S., Bin, L., Costa, L.G., Manzo, L. Arch. Toxicol. (1996) [Pubmed]
  33. Simultaneous determination of styrene, toluene, and xylene metabolites in urine by gas chromatography/mass spectrometry. Szucs, S., Tóth, L., Legoza, J., Sárváry, A., Adány, R. Arch. Toxicol. (2002) [Pubmed]
  34. Nonlinear amplification of circular dichroism activity upon cyclodimerization of a chiral saddle-shaped porphyrin. Mizuno, Y., Aida, T. Chem. Commun. (Camb.) (2003) [Pubmed]
  35. Determination of mandelic acid enantiomers in urine by derivatization in supercritical carbon dioxide prior to their determination by gas chromatography. Zougagh, M., Arce, L., Ríos, A., Valcárcel, M. Journal of chromatography. A. (2006) [Pubmed]
  36. Investigation of mandelic acid bonding on Pirkle type chromatographic stationary phases by Raman spectroscopy. Horváth, E., Kristóf, J., Frost, R.L., Rintoul, L., Rédey, A., Forsling, W. Journal of chromatography. A. (2000) [Pubmed]
  37. Effect of the mobile phase on the retention behavior of optical isomers of the mandelic acid derivative methyl 2-phenyl-2-(tetrahydropyranyloxy) acetate by chiral HPLC. Shen, B., Xu, X., Chen, J., Zhang, X., Xu, B. Chirality. (2006) [Pubmed]
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