Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Pemoline-dione 5-phenyl-1,3-oxazolidine-2,4- dione

Synonyms: CHEMBL1335, PEMOLINE DIONE, AG-G-06655, SureCN7864463, NSC-27303, ...

Libeer, J.C. et al., Gielsdorf, W.

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High impact information on NSC27303

Extraction problems due to the low solubility of pemoline are avoided by acid hydrolysis of the drug to 5-phenyl-2,4-oxazolidinedione, which then can be easily isolated by two-phase extraction with dichloromethane, ether, or chloroform [1].

Analytical, diagnostic and therapeutic context of NSC27303

These substances were therefore converted by acid hydrolysis to their common hydrolysis product 5-phenyl-2,4-oxazolidinedione, which can be detected with high sensitivity and selectivity by thin layer chromatography [2].

References

GLC determination of pemoline in biological fluids. Libeer, J.C., Schepens, P. Journal of pharmaceutical sciences. (1978) [Pubmed]
Determination of the psychostimulants pemoline, fenozolone and thozalinone in human urine by gas chromatography/mass spectrometry and thin layer chromatography. Gielsdorf, W. J. Clin. Chem. Clin. Biochem. (1982) [Pubmed]

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