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Chemical Compound Review

Dichloromethyl     dichloromethane

Synonyms: CHCl2, AR-1I4190, AC1L3W26, 3474-12-2, Methyl, dichloro-, ...
 
 
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Disease relevance of dichloromethane

 

Psychiatry related information on dichloromethane

 

High impact information on dichloromethane

  • Upon CdCl(2)-treatment, both Sertoli cells and the germ cells upregulated Fas ligand; this event was also suppressed by zinc protoporphyrin-IX and restored by dichloromethane [7].
  • They were associated with a Mg-ATPase which could be solubilized with dichloromethane from vesicle membranes, and which elutes upon gel filtration with a mol. wt. approximately 300 kd [8].
  • X-ray structural analysis of human deoxyhemoglobin crystals exposed to dichloromethane shows four unique binding sites [9].
  • Inasmuch as GSTT1 is responsible for the metabolic activation of dihaloalkanes, selenium deficiency may increase the susceptibility of rats to mutagens such as dichloromethane [10].
  • One-electron oxidation of 4a-e with FeCl(3) in dichloromethane results in the appearance of specific polaronic bands in the near-infrared region of the electronic absorption spectra, due to the generation of a radical cation species (polaron) on one of the quinquethiophenes, which electronically interacts with the remaining neutral species [11].
 

Chemical compound and disease context of dichloromethane

 

Biological context of dichloromethane

 

Anatomical context of dichloromethane

 

Associations of dichloromethane with other chemical compounds

 

Gene context of dichloromethane

 

Analytical, diagnostic and therapeutic context of dichloromethane

References

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  2. In vivo formation of mutagens by intraperitoneal administration of polycyclic aromatic hydrocarbons in animals during exposure to nitrogen dioxide. Miyanishi, K., Kinouchi, T., Kataoka, K., Kanoh, T., Ohnishi, Y. Carcinogenesis (1996) [Pubmed]
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  7. Leydig cell-derived heme oxygenase-1 regulates apoptosis of premeiotic germ cells in response to stress. Ozawa, N., Goda, N., Makino, N., Yamaguchi, T., Yoshimura, Y., Suematsu, M. J. Clin. Invest. (2002) [Pubmed]
  8. Synaptic vesicles contain an ATP-dependent proton pump and show 'knob-like' protrusions on their surface. Stadler, H., Tsukita, S. EMBO J. (1984) [Pubmed]
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  10. Protection conferred by selenium deficiency against aflatoxin B1 in the rat is associated with the hepatic expression of an aldo-keto reductase and a glutathione S-transferase subunit that metabolize the mycotoxin. McLeod, R., Ellis, E.M., Arthur, J.R., Neal, G.E., Judah, D.J., Manson, M.M., Hayes, J.D. Cancer Res. (1997) [Pubmed]
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  13. Method for spiking soil samples with organic compounds. Brinch, U.C., Ekelund, F., Jacobsen, C.S. Appl. Environ. Microbiol. (2002) [Pubmed]
  14. Dichloromethane metabolism and C1 utilization genes in Methylobacterium strains. Kayser, M.F., Ucurum, Z., Vuilleumier, S. Microbiology (Reading, Engl.) (2002) [Pubmed]
  15. Activity of extracts of Kigelia pinnata against melanoma and renal carcinoma cell lines. Houghton, P.J., Photiou, A., Uddin, S., Shah, P., Browning, M., Jackson, S.J., Retsas, S. Planta Med. (1994) [Pubmed]
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  17. A new gas chromatography-mass spectrometry method for simultaneous determination of total and free trans-3'-hydroxycotinine and cotinine in the urine of subjects receiving transdermal nicotine. Ji, A.J., Lawson, G.M., Anderson, R., Dale, L.C., Croghan, I.T., Hurt, R.D. Clin. Chem. (1999) [Pubmed]
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  19. Preliminary findings of quorum signal molecules in clinically stable lung allograft recipients. Ward, C., Cámara, M., Forrest, I., Rutherford, R., Pritchard, G., Daykin, M., Hardman, A., de Soyza, A., Fisher, A.J., Williams, P., Corris, P.A. Thorax (2003) [Pubmed]
  20. Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Pemble, S., Schroeder, K.R., Spencer, S.R., Meyer, D.J., Hallier, E., Bolt, H.M., Ketterer, B., Taylor, J.B. Biochem. J. (1994) [Pubmed]
  21. Effect of methylene chloride inhalation on replicative DNA synthesis in the lungs of female B6C3F1 mice. Kanno, J., Foley, J.F., Kari, F., Anderson, M.W., Maronpot, R.R. Environ. Health Perspect. (1993) [Pubmed]
  22. Protection by chlorophyllin against the covalent binding of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) to rat liver DNA. Dashwood, R.H. Carcinogenesis (1992) [Pubmed]
  23. Bioactivation of [13C]dichloromethane in mouse, rat, and human liver cytosol: 13C nuclear magnetic resonance spectroscopic studies. Hashmi, M., Dechert, S., Dekant, W., Anders, M.W. Chem. Res. Toxicol. (1994) [Pubmed]
  24. Studies of the extraction of bilirubin from human amniotic fluid. Bailey, D.N., Briggs, J.R. Am. J. Clin. Pathol. (2006) [Pubmed]
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  27. Molecular "compasses" and "gyroscopes." III. Dynamics of a phenylene rotor and clathrated benzene in a slipping-gear crystal lattice. Dominguez, Z., Dang, H., Strouse, M.J., Garcia-Garibay, M.A. J. Am. Chem. Soc. (2002) [Pubmed]
  28. Identification and quantification of 77 pesticides in groundwater using solid phase coupled to liquid-liquid microextraction and reversed-phase liquid chromatography. Vandecasteele, K., Gaus, I., Debreuck, W., Walraevens, K. Anal. Chem. (2000) [Pubmed]
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  31. Chlorella dichloromethane extract ameliorates NO production and iNOS expression through the down-regulation of NF kappa B activity mediated by suppressed oxidative stress in RAW 264.7 macrophages. Park, J.Y., Cho, H.Y., Kim, J.K., Noh, K.H., Yang, J.R., Ahn, J.M., Lee, M.O., Song, Y.S. Clin. Chim. Acta (2005) [Pubmed]
  32. Hydrophilic and lipophilic antioxidant activities of guava fruits. Thaipong, K., Boonprakob, U., Cisneros-Zevallos, L., Byrne, D.H. Southeast Asian J. Trop. Med. Public Health (2005) [Pubmed]
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  35. Usefulness of follow-up liver-function tests after dichloromethane exposure. Puurunen, J., Sotaniemi, E. Lancet (1985) [Pubmed]
  36. Human bone cells in culture metabolize 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3. Howard, G.A., Turner, R.T., Sherrard, D.J., Baylink, D.J. J. Biol. Chem. (1981) [Pubmed]
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