Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AG-K-68444 2-amino-5-oxo-pentanoic acid

Synonyms: CTK7I0765, AKOS006365052, AC1L1A5H, 496-92-4, 2-Amino-5-oxopentanoic acid, ...

Hempel, J. et al., Aral, B. et al., Hayzer, D.J. et al.

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Disease relevance of glutamate-semialdehyde

Proline biosynthesis in Escherichia coli. Purification and characterisation of glutamate-semialdehyde dehydrogenase [1].

High impact information on glutamate-semialdehyde

delta 1-pyrroline-5-carboxylate synthetase (P5CS) catalyzes the ATP and the NAD(P)H-dependent conversion of L-glutamate to glutamic gamma-semialdehyde (GSA) which is the metabolic precursor for proline biosynthesis [2].
The amino acid sequences of nine tryptic peptides (containing altogether 105 amino acids) from human liver glutamic gamma-semialdehyde of dehydrogenase (hitherto designated as ALDH4) were found to correspond, at 33-66% identity, to segments from the yeast 1-proline-5-carboxylate (P5C) dehydrogenase encoded by the PUT2 gene [3].

References

Proline biosynthesis in Escherichia coli. Purification and characterisation of glutamate-semialdehyde dehydrogenase. Hayzer, D.J., Leisinger, T. Eur. J. Biochem. (1982) [Pubmed]
Database cloning human delta 1-pyrroline-5-carboxylate synthetase (P5CS) cDNA: a bifunctional enzyme catalyzing the first 2 steps in proline biosynthesis. Aral, B., Schlenzig, J.S., Liu, G., Kamoun, P. C. R. Acad. Sci. III, Sci. Vie (1996) [Pubmed]
Human liver glutamic gamma-semialdehyde dehydrogenase: structural relationship to the yeast enzyme. Hempel, J., Eckey, R., Berie, D., Romovacek, H., Agarwal, D.P., Goedde, H.W. Comp. Biochem. Physiol., B (1992) [Pubmed]

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