Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

NDHU 1-nitroso-1,3-diazinane-2,4- dione

Synonyms: NO-Dhu, CCRIS 1563, AG-E-17484, NSC-90999, LS-7566, ...

Lawson, T.A. et al., Pelfrene, A. et al.

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Disease relevance of NO-Dhu

In acute toxicity tests, ip injection of saline solutions of 1-nitroso-5,6-dihydrouracil [(NDHU) CAS: 16813-36-8; 1-nitrosohydrouracil], a strong liver carcinogen in rats, produced only mild liver toxicity but marked focal degeneration of myocardial fibers [1].
Two peritoneal mesotheliomas were induced in rats during a carcinogenicity study of 1-nitroso-5,6-dihydrouracil (NO-DHU) injected intraperitoneally [2].

References

Persistence of DNA single-strand breaks and other tests as indicators of the liver carcinogenicity of 1-nitroso-5,6-dihydrouracil and the noncarcinogenicity of 1-nitroso-5,6-dihydrothymine. Lawson, T.A., Mirvish, S.S., Pour, P., Williams, G. J. Natl. Cancer Inst. (1984) [Pubmed]
Histology of chemically induced mesotheliomas in MRC-Wistar rats. Pelfrene, A., Garcia, H. Tumori. (1975) [Pubmed]

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