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Chemical Compound Review:

Fenaza 4-[2-(4-tert- butylphenyl)ethoxy]quinazoline

Synonyms: Fenazachin, Fenazaquin, Fenazaquine, Magus, SureCN26216, ...

Rowlands, J.C. et al., Kumar, V. et al.

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Disease relevance of Fenazaquin

In MCF-7 human breast cancer cells, rotenone, deguelin and two structurally-unrelated miticides (pyridaben and fenazaquin) inhibit not only NADH: ubiquinone oxidoreductase but also induced ornithine decarboxylase activity with IC50 values of < 1 to 70 nM [1].

Analytical, diagnostic and therapeutic context of Fenazaquin

Samples (green shoots, made tea and its brew) were analyzed for fenazaquin and quantification was by high performance liquid chromatography using a UV detector [2].

References

NADH: ubiquinone oxidoreductase inhibitors block induction of ornithine decarboxylase activity in MCF-7 human breast cancer cells. Rowlands, J.C., Casida, J.E. Pharmacol. Toxicol. (1998) [Pubmed]
Investigation in tea on fate of fenazaquin residue and its transfer in brew. Kumar, V., Tewary, D.K., Ravindranath, S.D., Shanker, A. Food Chem. Toxicol. (2006) [Pubmed]

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