Disease relevance of NCI 129

• (i) Powerful contact toxicity with an LC(50) of 5.2 mg litre(-1) after 24 h that was similar to that of pyridaben (LC(50) = 3.4 mg litre(-1)) and significantly superior to that of omethoate (LC(50) = 122 mg litre(-1)) [1].

High impact information on NCI 129

• These findings on cubé insecticide constituents and our earlier study comparing rotenone and pyridaben miticide indicate that inhibition of NADH:ubiquinone oxidoreductase activity lowers the level of induced ODC activity leading to the antiproliferative effect and anticancer action [2].
• The cells expressing the Ndi1 protein were resistant to known inhibitors of complex I, such as rotenone and pyridaben [3].
• The reaction rates decreased with the increase of pH value, which can be attributed to the surface charge variations of pyridaben adsorbed onto TiO2 particles [4].
• Four population groups were established based on either the habitats (greenhouse and apple orchard) or acaricides (fenpyroximate and pyridaben) [5].
• In rat brain mitochondria, rotenone and pyridaben markedly decreased mtNOS functional activity with NAD-dependent substrates but not when the substrate was succinate [6].

Biological context of NCI 129

• The IC50 of rotenone and pyridaben for complex I inhibition were in the range 1.7-2.2 microM [6].
• The determination of NADH-cytochrome c reductase, succinate-cytochrome c reductase and cytochrome oxidase activities in rat brain submitochondrial showed again the selective inhibition of Complex I by rotenone and pyridaben, whereas paraquat produced a non-selective inhibition affecting all the respiratory chain complexes [6].

Associations of NCI 129 with other chemical compounds

• Toxicants that inhibit selectively NADH-dehydrogenase activity, as rotenone or pyridaben, also show a selective inhibition of O2 uptake and respiratory control in rat brain mitochondria in the presence of NAD-dependent substrates [6].

Analytical, diagnostic and therapeutic context of NCI 129

• A higher than recommended rate of pyridaben (2160 g ha(-1)) applied before bloom was disruptive--P ulmi-days after treatment were actually greater than with the untreated control [7].

References