Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AGN-PC-00K8XP 10,13-dimethyl-17-(6- methylheptan-2-yl)-2...

Synonyms: SureCN1917363, AC1Q7BBT, AR-1I2145, AC1L3BS5, Cholest-5-ene-3,4-diol

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High impact information on AC1Q7BBT

Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4 [1].
Together, these data suggest that 4beta-hydroxycholesterol in human circulation is formed by a cytochrome P450 enzyme [1].
The rate of exchange between erythrocytes and plasma was found to be high for 27-hydroxycholesterol and 24S-hydroxycholesterol, and hardly possible to measure for 4beta-hydroxycholesterol and cholesterol [2].
However, the present study had sufficient power to detect only a considerably smaller rifampicin-induced increase in 4beta-hydroxycholesterol in carriers of the SLCO1B1 c.521C allele compared to subjects with the reference genotype [3].

Gene context of AC1Q7BBT

Within all three populations there were significant differences in 4beta-hydroxycholesterol levels between the CYP3A5 genotypes [4].

References

Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4. Bodin, K., Bretillon, L., Aden, Y., Bertilsson, L., Broomé, U., Einarsson, C., Diczfalusy, U. J. Biol. Chem. (2001) [Pubmed]
On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function. Meaney, S., Bodin, K., Diczfalusy, U., Björkhem, I. J. Lipid Res. (2002) [Pubmed]
Effect of SLCO1B1 polymorphism on induction of CYP3A4 by rifampicin. Niemi, M., Kivistö, K.T., Diczfalusy, U., Bodin, K., Bertilsson, L., Fromm, M.F., Eichelbaum, M. Pharmacogenet. Genomics (2006) [Pubmed]
4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians. Diczfalusy, U., Miura, J., Roh, H.K., Mirghani, R.A., Sayi, J., Larsson, H., Bodin, K.G., Allqvist, A., Jande, M., Kim, J.W., Aklillu, E., Gustafsson, L.L., Bertilsson, L. Pharmacogenet. Genomics (2008) [Pubmed]

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