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Chemical Compound Review

SureCN159618     (3S,8S,9S,10R,13R,14S,17R)- 17-[(2R)-7...

Synonyms: CPD-7287, AG-A-46323, CHEBI:17703, CTK8A1618, LMST01010057, ...
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Disease relevance of C06340


Psychiatry related information on C06340


High impact information on C06340


Chemical compound and disease context of C06340


Biological context of C06340


Anatomical context of C06340


Associations of C06340 with other chemical compounds


Gene context of C06340


Analytical, diagnostic and therapeutic context of C06340


  1. Cholesterol 7-hydroxylase knockout mouse: a model for monohydroxy bile acid-related neonatal cholestasis. Arnon, R., Yoshimura, T., Reiss, A., Budai, K., Lefkowitch, J.H., Javitt, N.B. Gastroenterology (1998) [Pubmed]
  2. Bile acid metabolism in cirrhosis. VIII. Quantitative evaluation of bile acid synthesis from [7 beta-3H]7 alpha-hydroxycholesterol and [G-3H]26-hydroxycholesterol. Goldman, M., Vlahcevic, Z.R., Schwartz, C.C., Gustafsson, J., Swell, L. Hepatology (1982) [Pubmed]
  3. Oxysterol mixtures, in atheroma-relevant proportions, display synergistic and proapoptotic effects. Larsson, D.A., Baird, S., Nyhalah, J.D., Yuan, X.M., Li, W. Free Radic. Biol. Med. (2006) [Pubmed]
  4. Cerebrotendinous xanthomatosis: reduced serum 26-hydroxycholesterol. Javitt, N.B., Kok, E., Cohen, B., Burstein, S. J. Lipid Res. (1982) [Pubmed]
  5. Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol. Björkhem, I., Starck, L., Andersson, U., Lütjohann, D., von Bahr, S., Pikuleva, I., Babiker, A., Diczfalusy, U. J. Lipid Res. (2001) [Pubmed]
  6. Oxysterols and Alzheimer's disease. Björkhem, I., Heverin, M., Leoni, V., Meaney, S., Diczfalusy, U. Acta Neurol. Scand., Suppl. (2006) [Pubmed]
  7. Oxysterols present in atherosclerotic tissue decrease the expression of lipoprotein lipase messenger RNA in human monocyte-derived macrophages. Hultén, L.M., Lindmark, H., Diczfalusy, U., Björkhem, I., Ottosson, M., Liu, Y., Bondjers, G., Wiklund, O. J. Clin. Invest. (1996) [Pubmed]
  8. Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols. Lala, D.S., Syka, P.M., Lazarchik, S.B., Mangelsdorf, D.J., Parker, K.L., Heyman, R.A. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  9. Atherosclerosis and sterol 27-hydroxylase: evidence for a role of this enzyme in elimination of cholesterol from human macrophages. Björkhem, I., Andersson, O., Diczfalusy, U., Sevastik, B., Xiu, R.J., Duan, C., Lund, E. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  10. Transcriptional regulation of human CYP27 integrates retinoid, peroxisome proliferator-activated receptor, and liver X receptor signaling in macrophages. Szanto, A., Benko, S., Szatmari, I., Balint, B.L., Furtos, I., Rühl, R., Molnar, S., Csiba, L., Garuti, R., Calandra, S., Larsson, H., Diczfalusy, U., Nagy, L. Mol. Cell. Biol. (2004) [Pubmed]
  11. Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes. Pandak, W.M., Hylemon, P.B., Ren, S., Marques, D., Gil, G., Redford, K., Mallonee, D., Vlahcevic, Z.R. Hepatology (2002) [Pubmed]
  12. Plasma oxysterols and tocopherol in patients with diabetes mellitus and hyperlipidemia. Murakami, H., Tamasawa, N., Matsui, J., Yasujima, M., Suda, T. Lipids (2000) [Pubmed]
  13. NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols. Frolov, A., Zielinski, S.E., Crowley, J.R., Dudley-Rucker, N., Schaffer, J.E., Ory, D.S. J. Biol. Chem. (2003) [Pubmed]
  14. Generation of regulatory oxysterols: 26-hydroxylation of cholesterol by ovarian mitochondria. Rennert, H., Fischer, R.T., Alvarez, J.G., Trzaskos, J.M., Strauss, J.F. Endocrinology (1990) [Pubmed]
  15. 7 alpha-hydroxylation of 27-hydroxycholesterol: biologic role in the regulation of cholesterol synthesis. Martin, K.O., Reiss, A.B., Lathe, R., Javitt, N.B. J. Lipid Res. (1997) [Pubmed]
  16. Effect of naturally reduced ovarian function on plasma lipoprotein and 27-hydroxycholesterol levels in baboons (Papio sp.). Chen, L.D., Kushwaha, R.S., McGill, H.C., Rice, K.S., Carey, K.D. Atherosclerosis (1998) [Pubmed]
  17. 7alpha-Hydroxylation and 3-dehydrogenation abolish the ability of 25-hydroxycholesterol and 27-hydroxycholesterol to induce apoptosis in thymocytes. Zhang, J., Xue, Y., Jondal, M., Sjövall, J. Eur. J. Biochem. (1997) [Pubmed]
  18. Formation of 7 alpha- and 7 beta-hydroxylated bile acid precursors from 27-hydroxycholesterol in human liver microsomes and mitochondria. Shoda, J., Toll, A., Axelson, M., Pieper, F., Wikvall, K., Sjövall, J. Hepatology (1993) [Pubmed]
  19. Elimination of cholesterol in macrophages and endothelial cells by the sterol 27-hydroxylase mechanism. Comparison with high density lipoprotein-mediated reverse cholesterol transport. Babiker, A., Andersson, O., Lund, E., Xiu, R.J., Deeb, S., Reshef, A., Leitersdorf, E., Diczfalusy, U., Björkhem, I. J. Biol. Chem. (1997) [Pubmed]
  20. Disruption of the oxysterol 7alpha-hydroxylase gene in mice. Li-Hawkins, J., Lund, E.G., Turley, S.D., Russell, D.W. J. Biol. Chem. (2000) [Pubmed]
  21. Adipocytic differentiation and liver x receptor pathways regulate the accumulation of triacylglycerols in human vascular smooth muscle cells. Davies, J.D., Carpenter, K.L., Challis, I.R., Figg, N.L., McNair, R., Proudfoot, D., Weissberg, P.L., Shanahan, C.M. J. Biol. Chem. (2005) [Pubmed]
  22. Stromal cells of the human postmenopausal ovary display a distinctive biochemical and molecular phenotype. Jabara, S., Christenson, L.K., Wang, C.Y., McAllister, J.M., Javitt, N.B., Dunaif, A., Strauss, J.F. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  23. Effects of 26-aminocholesterol, 27-hydroxycholesterol, and 25-hydroxycholesterol on proliferation and cholesterol homeostasis in arterial myocytes. Corsini, A., Verri, D., Raiteri, M., Quarato, P., Paoletti, R., Fumagalli, R. Arterioscler. Thromb. Vasc. Biol. (1995) [Pubmed]
  24. Bile acid synthesis in man. II. Determination of 7 alpha-hydroxycholesterol, (22R)-22-hydroxycholesterol, and 26-hydroxycholesterol in human meconium. Lavy, U., Burstein, S., Gut, M., Javitt, N.B. J. Lipid Res. (1977) [Pubmed]
  25. Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease. Heverin, M., Bogdanovic, N., Lütjohann, D., Bayer, T., Pikuleva, I., Bretillon, L., Diczfalusy, U., Winblad, B., Björkhem, I. J. Lipid Res. (2004) [Pubmed]
  26. Bile acid synthesis in rat liver peroxisomes: metabolism of 26-hydroxycholesterol to 3 beta-hydroxy-5-cholenoic acid. Krisans, S.K., Thompson, S.L., Pena, L.A., Kok, E., Javitt, N.B. J. Lipid Res. (1985) [Pubmed]
  27. On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function. Meaney, S., Bodin, K., Diczfalusy, U., Björkhem, I. J. Lipid Res. (2002) [Pubmed]
  28. Esterification of oxysterols by human plasma lecithin-cholesterol acyltransferase. Szedlacsek, S.E., Wasowicz, E., Hulea, S.A., Nishida, H.I., Kummerow, F.A., Nishida, T. J. Biol. Chem. (1995) [Pubmed]
  29. Differential expression of cholesterol hydroxylases in Alzheimer's disease. Brown, J., Theisler, C., Silberman, S., Magnuson, D., Gottardi-Littell, N., Lee, J.M., Yager, D., Crowley, J., Sambamurti, K., Rahman, M.M., Reiss, A.B., Eckman, C.B., Wolozin, B. J. Biol. Chem. (2004) [Pubmed]
  30. Expression of key enzymes in bile acid biosynthesis during development: CYP7B1-mediated activities show tissue-specific differences. Norlin, M. J. Lipid Res. (2002) [Pubmed]
  31. Mechanism of accumulation of cholesterol and cholestanol in tendons and the role of sterol 27-hydroxylase (CYP27A1). von Bahr, S., Movin, T., Papadogiannakis, N., Pikuleva, I., Rönnow, P., Diczfalusy, U., Björkhem, I. Arterioscler. Thromb. Vasc. Biol. (2002) [Pubmed]
  32. Conditional response of the human steroidogenic acute regulatory protein gene promoter to sterol regulatory element binding protein-1a. Christenson, L.K., Osborne, T.F., McAllister, J.M., Strauss, J.F. Endocrinology (2001) [Pubmed]
  33. Transport of cholesterol into mitochondria is rate-limiting for bile acid synthesis via the alternative pathway in primary rat hepatocytes. Pandak, W.M., Ren, S., Marques, D., Hall, E., Redford, K., Mallonee, D., Bohdan, P., Heuman, D., Gil, G., Hylemon, P. J. Biol. Chem. (2002) [Pubmed]
  34. Sterol 27-hydroxylase: high levels of activity in vascular endothelium. Reiss, A.B., Martin, K.O., Javitt, N.B., Martin, D.W., Grossi, E.A., Galloway, A.C. J. Lipid Res. (1994) [Pubmed]
  35. Synthesis of 27-hydroxycholesterol in rat liver mitochondria: HPLC assay and marked activation by exogenous cholesterol. Petrack, B., Latario, B.J. J. Lipid Res. (1993) [Pubmed]
  36. A minimally invasive technique for the evaluation of the regulatory steps of the two major pathways of bile acid synthesis. Del Puppo, M., Crosignani, A., Longo, M., Zuin, M., Podda, M., Galli, G., De Fabiani, E., Ciuffreda, P., Santaniello, E., Javitt, N.B., Kienle, M.G. Clin. Chim. Acta (2005) [Pubmed]
  37. Effect of pravastatin on plasma sterols and oxysterols in men. Thelen, K.M., Lütjohann, D., Vesalainen, R., Janatuinen, T., Knuuti, J., von Bergmann, K., Lehtimäki, T., Laaksonen, R. Eur. J. Clin. Pharmacol. (2006) [Pubmed]
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