Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Neo-Eunomin [(8R,9S,10R,13S,14S,17R)-6- chloro-17...

Synonyms: Clordion, Minipill, Normenon, Chlordion, Luteran, ...

Murakoshi, M. et al., Werner, S. et al.

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High impact information on Chlormadinon acetate

CMA and MGA were assayed in two of the liver cell preparations from the female donors [1].
In contrast, combined treatment with TZP-4238 (Group 3) or CMA (Group 4) produced marked atrophy of the glandular epithelium, and the number of BrdU-positive cells were remarkably decreased compared with Group 2 [2].
Furthermore, nuclear immunostaining of androgen receptor was remarkably decreased after combined treatment with TZP-4238 or CMA [2].

References

Formation of DNA adducts by cyproterone acetate and some structural analogues in primary cultures of human hepatocytes. Werner, S., Kunz, S., Beckurts, T., Heidecke, C.D., Wolff, T., Schwarz, L.R. Mutat. Res. (1997) [Pubmed]
Inhibition of steroid-induced prostatic hyperplasia in rats by treatment with anti-androgen (TZP-4238). Murakoshi, M., Tagawa, M., Inada, R., Suzuki, M., Mizokami, A., Watanabe, K. Endocr. J. (1993) [Pubmed]

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