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Chemical Compound Review:

arabitol (2R,4R)-pentane-1,2,3,4,5- pentol

Synonyms: Lyxitol, D-Lyxitol, D-Arabinol, D-Arabitol, L-arabitol, ...

Latsis, T. et al., Fosgerau, K. et al.

Fosgerau, Mittelman, Sunehag, Dea, Lundgren, Bergman,

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High impact information on D-Arabinol

DAB, in contrast, induced a small degree of phosphorylation of phosphorylase [1].
Despite causing phosphorylation (activation) of phosphorylase, DAB is a very potent inhibitor of glycogenolysis in both the absence and presence of glucagon [1].
When dogs were treated acutely with DAB in addition to high glucagon infusion, the stimulation of the glycogenolytic rate was completely suppressed [2].

References

Diverse effects of two allosteric inhibitors on the phosphorylation state of glycogen phosphorylase in hepatocytes. Latsis, T., Andersen, B., Agius, L. Biochem. J. (2002) [Pubmed]
Lack of hepatic "interregulation" during inhibition of glycogenolysis in a canine model. Fosgerau, K., Mittelman, S.D., Sunehag, A., Dea, M.K., Lundgren, K., Bergman, R.N. Am. J. Physiol. Endocrinol. Metab. (2001) [Pubmed]

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