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Chemical Compound Review:

Pimprinine 3-(2-methyl-1,3-oxazol-5-yl)- 1H-indole

Synonyms: AG-D-74171, CCG-40387, NSC-80793, SureCN12364396, AC1L3WRI, ...

Pettit, G.R. et al., Naik, S.R. et al., Umehara, K. et al.

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Disease relevance of NSC 80793

Pimprinine, an extracellular alkaloid produced by Streptomyces CDRIL-312: fermentation, isolation and pharmacological activity [1].
Investigation of Pseudomonas syringae pv. coronafaciens cancer cell growth inhibitory constituents led to the isolation of 2-isobutyl-5-(3-indolyl)oxazole (1) and 2-n-pentyl-5-(3-indolyl)oxazole (2f), designated labradorins 1 (1) and 2 (2f), related to pimprinine (2a) [2].

High impact information on NSC 80793

Pimprinine and the two new analogs have potent inhibitory effects on platelet aggregation [3].

Analytical, diagnostic and therapeutic context of NSC 80793

Pimprinine was subsequently purified using silica gel column chromatography and also by preparatory thin layer chromatography [1].

References

Pimprinine, an extracellular alkaloid produced by Streptomyces CDRIL-312: fermentation, isolation and pharmacological activity. Naik, S.R., Harindran, J., Varde, A.B. J. Biotechnol. (2001) [Pubmed]
Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens. Pettit, G.R., Knight, J.C., Herald, D.L., Davenport, R., Pettit, R.K., Tucker, B.E., Schmidt, J.M. J. Nat. Prod. (2002) [Pubmed]
Studies on new antiplatelet agents, WS-30581 A and B. Umehara, K., Yoshida, K., Okamoto, M., Iwami, M., Tanaka, H., Kohsaka, M., Imanaka, H. J. Antibiot. (1984) [Pubmed]

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