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Chemical Compound Review:

PubChem9776 quinoxaline-2-carboxylic acid

Synonyms: CHEMBL151797, SureCN354679, ACMC-1BL7G, AG-B-92059, AG-H-54769, ...

Glund, K. et al., Hutchinson, M.J. et al., Rutalj, M. et al., Gauvreau, D. et al., Schmoock, G. et al.

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Disease relevance of NSC 86873

A quinoxaline-2-carboxylic acid activating enzyme was purified to homogeneity from triostin-producing Streptomyces triostinicus [1].

High impact information on NSC 86873

Cloning of the gene for the QA-binding protein revealed that it is the fatty acyl carrier protein, AcpPSE, of the fatty acid synthase of S. echinatus and S. triostinicus [2].
Biosynthesis of quinoxaline antibiotics: purification and characterization of the quinoxaline-2-carboxylic acid activating enzyme from Streptomyces triostinicus [1].
Development and validation of an improved method for confirmation of the carbadox metabolite, quinoxaline-2-carboxylic acid, in porcine liver using LC-electrospray MS-MS according to revised EU criteria for veterinary drug residue analysis [3].
The concentration of quinoxaline-2-carboxylic acid (QCA) determined by HPLC after alkaline hydrolysis of liver and muscle of swine, ranged from < 3 ng/g to 45.3 ng/g in liver, and from < 3 ng/g to 10.8 ng/g in muscle samples [4].
Directed biosynthesis of novel derivatives of echinomycin by Streptomyces echinatus. I. Effect of exogenous analogues of quinoxaline-2-carboxylic acid on the fermentation [5].

References

Biosynthesis of quinoxaline antibiotics: purification and characterization of the quinoxaline-2-carboxylic acid activating enzyme from Streptomyces triostinicus. Glund, K., Schlumbohm, W., Bapat, M., Keller, U. Biochemistry (1990) [Pubmed]
Functional cross-talk between fatty acid synthesis and nonribosomal peptide synthesis in quinoxaline antibiotic-producing streptomycetes. Schmoock, G., Pfennig, F., Jewiarz, J., Schlumbohm, W., Laubinger, W., Schauwecker, F., Keller, U. J. Biol. Chem. (2005) [Pubmed]
Development and validation of an improved method for confirmation of the carbadox metabolite, quinoxaline-2-carboxylic acid, in porcine liver using LC-electrospray MS-MS according to revised EU criteria for veterinary drug residue analysis. Hutchinson, M.J., Young, P.Y., Hewitt, S.A., Faulkner, D., Kennedy, D.G. The Analyst. (2002) [Pubmed]
Quinoxaline-2-carboxylic acid (QCA) in swine liver and muscle. Rutalj, M., Bazulić, D., Sapunar-Postruznik, J., Zivković, J., Ljubicić, I. Food additives and contaminants. (1996) [Pubmed]
Directed biosynthesis of novel derivatives of echinomycin by Streptomyces echinatus. I. Effect of exogenous analogues of quinoxaline-2-carboxylic acid on the fermentation. Gauvreau, D., Waring, M.J. Can. J. Microbiol. (1984) [Pubmed]

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