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MeSH Review

Drug Residues

 
 
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Disease relevance of Drug Residues

 

High impact information on Drug Residues

  • A resonable scenario, based on assumptions as well as literature data, has been presented for the release of cysteine conjugates of drug residues from protein [1].
  • This paper explores advantages of using ND-APCI for the determination and confirmation of drug residues that might be found in food matrices, including malachite green residues in fish tissue and avermectin residues in milk [2].
  • Orthogonal array designs (OADs) were applied for the first time to optimize liquid-liquid-liquid microextraction (LLLME) conditions for the analysis of three nonsteroidal anti-inflammatory drug residues (2-(4-chlorophenoxy)-2-methylpropionic acid, ketoprofen, and naproxen) in wastewater samples [3].
  • To remove drug residues from stainless steel and glass surfaces, the first cotton swab must be soaked preferably in acetonitrile whereas, on vinyl surfaces better results are obtained using methanol [4].
  • Development and validation of an improved method for confirmation of the carbadox metabolite, quinoxaline-2-carboxylic acid, in porcine liver using LC-electrospray MS-MS according to revised EU criteria for veterinary drug residue analysis [5].
 

Chemical compound and disease context of Drug Residues

 

Biological context of Drug Residues

  • It is concluded that the kinetics of the oxytetracycline residues follow the same pattern as the drug residues in the serum, and these principles seem to apply in normal and in emergency-slaughtered dairy cows [7].
 

Anatomical context of Drug Residues

 

Associations of Drug Residues with chemical compounds

  • Development and validation of a method for the confirmation of nicarbazin in chicken liver and eggs using LC-electrospray MS-MS according to the revised EU criteria for veterinary drug residue analysis [9].
  • The ability of immunobiosensor based bile screening to predict violative tissue residues (greater than the maximum residue limit; MRL) was compared with results achieved using two conventional EIAs for two of these drug residues (SMT and SDZ) [10].
  • Following extraction with ethyl acetate (muscle, kidney and liver) or diethyl ether (fat) and clean-up of the tissue extract, the drug residue was isolated using a C18 solid-phase extraction column [11].
  • The effect of cooking on veterinary drug residues in food. Part 8. Benzylpenicillin [12].
  • The effect of cooking on veterinary drug residues in food: 4. Oxytetracycline [13].
 

Gene context of Drug Residues

 

Analytical, diagnostic and therapeutic context of Drug Residues

References

  1. Is the toxicity of cysteine conjugates formed during mercapturic acid biosynthesis relevant to the toxicity of covalently bound drug residues? Stevens, J.L., Wallin, A. Drug Metab. Rev. (1990) [Pubmed]
  2. No-discharge atmospheric pressure chemical ionization: evaluation and application to the analysis of animal drug residues in complex matrices. Turnipseed, S.B., Andersen, W.C., Karbiwnyk, C.M., Roybal, J.E., Miller, K.E. Rapid Commun. Mass Spectrom. (2006) [Pubmed]
  3. Orthogonal array designs for the optimization of liquid-liquid-liquid microextraction of nonsteroidal anti-inflammatory drugs combined with high-performance liquid chromatography-ultraviolet detection. Wu, J., Lee, H.K. Journal of chromatography. A. (2005) [Pubmed]
  4. Development and validation of a liquid chromatographic method for determination of lacidipine residues on surfaces in the manufacture of pharmaceuticals. Nozal, M.J., Bernal, J.L., Jiménez, J.J., Martín, M.T., Diez, F.J. Journal of chromatography. A. (2004) [Pubmed]
  5. Development and validation of an improved method for confirmation of the carbadox metabolite, quinoxaline-2-carboxylic acid, in porcine liver using LC-electrospray MS-MS according to revised EU criteria for veterinary drug residue analysis. Hutchinson, M.J., Young, P.Y., Hewitt, S.A., Faulkner, D., Kennedy, D.G. The Analyst. (2002) [Pubmed]
  6. Effects of residues of deltamethrin in cattle faeces on the development and survival of three species of dung-breeding insect. Wardhaugh, K.G., Longstaff, B.C., Lacey, M.J. Aust. Vet. J. (1998) [Pubmed]
  7. Tissue distribution and residues of oxytetracycline in normal and emergency-slaughtered ruminants. Nouws, J.F., Ziv, G. Tijdschrift voor diergeneeskunde. (1978) [Pubmed]
  8. Use of tissue-fluid correlations to estimate gentamicin residues in kidney tissue of Holstein steers. Chiesa, O.A., von Bredow, J., Heller, D., Nochetto, C., Smith, M., Moulton, K., Thomas, M. J. Vet. Pharmacol. Ther. (2006) [Pubmed]
  9. Development and validation of a method for the confirmation of nicarbazin in chicken liver and eggs using LC-electrospray MS-MS according to the revised EU criteria for veterinary drug residue analysis. Yakkundi, S., Cannavan, A., Elliott, C.T., Lovgren, T., Kennedy, D.G. The Analyst. (2001) [Pubmed]
  10. Immunobiosensor--an alternative to enzyme immunoassay screening for residues of two sulfonamides in pigs. Crooks, S.R., Baxter, G.A., O'Connor, M.C., Elliot, C.T. The Analyst. (1998) [Pubmed]
  11. Reversed-phase high-performance liquid chromatographic determination of dexamethasone in bovine tissues. Shearan, P., O'Keeffe, M., Smyth, M.R. The Analyst. (1991) [Pubmed]
  12. The effect of cooking on veterinary drug residues in food. Part 8. Benzylpenicillin. Rose, M.D., Bygrave, J., Farrington, W.H., Shearer, G. The Analyst. (1997) [Pubmed]
  13. The effect of cooking on veterinary drug residues in food: 4. Oxytetracycline. Rose, M.D., Bygrave, J., Farrington, W.H., Shearer, G. Food additives and contaminants. (1996) [Pubmed]
  14. Effect of cooking on veterinary drug residues in food. Part 9. Nitroimidazoles. Rose, M.D., Bygrave, J., Sharman, M. The Analyst. (1999) [Pubmed]
  15. Confirmation of identity by gas chromatography/tandem mass spectrometry of sulfathiazole, sulfamethazine, sulfachloropyridazine, and sulfadimethoxine from bovine or swine liver extracts after quantitation by gas chromatography/electron-capture detection. Matusik, J.E., Sternal, R.S., Barnes, C.J., Sphon, J.A. Journal - Association of Official Analytical Chemists. (1990) [Pubmed]
  16. Dexamethasone and flumethasone residues in milk of intramuscularly dosed cows. Reding, J., Sahin, A., Schlatter, J., Naegeli, H. J. Vet. Pharmacol. Ther. (1997) [Pubmed]
 
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