Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

CHEMBL1234254 (2R,3S,5R)-2-(hydroxymethyl)- 5-(6...

Synonyms: SureCN2048956, CHEBI:43971, AC1L3XZI, AR-1H4969, NSC 103543, ...

Parker, W.B. et al., Bharara, S. et al.

Parker, Allan, Hassan, Secrist, Sorscher, Waud,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of MDR

The E. coli PNP suicide gene sensitizes solid tumors to nucleoside prodrugs, such as 6-methylpurine-2'-deoxyriboside (MeP-dR) [1].

High impact information on MDR

The selective expression of Escherichia coli purine nucleoside phosphorylase (PNP) in solid tumors has been successfully used to activate two purine nucleoside analogs [9-(2-deoxy-beta-D-ribofuranosyl)-6-methylpurine (MeP-dR) and 9-beta-D-arabinofuranosyl-2-fluoroadenine (F-araA)] resulting in lasting tumor regressions and cures [2].

References

Antibiotic-mediated chemoprotection enhances adaptation of E. coli PNP for herpes simplex virus-based glioma therapy. Bharara, S., Sorscher, E.J., Gillespie, G.Y., Lindsey, J.R., Hong, J.S., Curlee, K.V., Allan, P.W., Gadi, V.K., Alexander, S.A., Secrist, J.A., Parker, W.B., Waud, W.R. Hum. Gene Ther. (2005) [Pubmed]
Antitumor activity of 2-fluoro-2'-deoxyadenosine against tumors that express Escherichia coli purine nucleoside phosphorylase. Parker, W.B., Allan, P.W., Hassan, A.E., Secrist, J.A., Sorscher, E.J., Waud, W.R. Cancer Gene Ther. (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share