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Chemical Compound Review

Fludarabine     (2R,3S,4S,5R)-2-(6-amino-2- fluoro-purin-9...

Synonyms: F-Ara-A, SureCN3510, CCRIS 3382, cc-626, AG-B-74533, ...
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Disease relevance of fludara


Psychiatry related information on fludara

  • A series of 30 patients who were not eligible for standard conditioning therapy received transplants from HLA-matched related (n = 14) or unrelated (n = 16) donors after administration of treosulfan 10 g/m2 intravenously daily for 3 days and fludarabine 30 mg/m2 intravenously daily for 5 days [5].

High impact information on fludara


Chemical compound and disease context of fludara


Biological context of fludara

  • A Fas-blocking antibody (ZB4) did not inhibit spontaneous, chlorambucil-, fludarabine-, or radiation-induced apoptosis [15].
  • Our findings support a role of fludarabine-mediated DNA repair inhibition as a mechanism critical for the cytotoxic synergy of the 2 drugs [16].
  • For example, fludarabine sensitized host stem cells to the toxicity of TBI, because animals conditioned with both agents had higher chimerism than animals conditioned with TBI alone (P <.05) [17].
  • Inhibiting STAT1alpha by STAT1beta increased the growth rate of transfected cells and their resistance to fludarabine-induced apoptosis and cell cycle arrest [18].
  • When adaphostin was combined with fludarabine (F-ARA-AMP), a synergistic effect on cell death was observed in all 10 CLL samples [19].

Anatomical context of fludara


Associations of fludara with other chemical compounds


Gene context of fludara


Analytical, diagnostic and therapeutic context of fludara


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  3. Response to 2-chlorodeoxyadenosine in patients with B-cell chronic lymphocytic leukemia resistant to fludarabine. Juliusson, G., Elmhorn-Rosenborg, A., Liliemark, J. N. Engl. J. Med. (1992) [Pubmed]
  4. Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation. Childs, R., Chernoff, A., Contentin, N., Bahceci, E., Schrump, D., Leitman, S., Read, E.J., Tisdale, J., Dunbar, C., Linehan, W.M., Young, N.S., Barrett, A.J. N. Engl. J. Med. (2000) [Pubmed]
  5. Treosulfan and fludarabine: a new toxicity-reduced conditioning regimen for allogeneic hematopoietic stem cell transplantation. Casper, J., Knauf, W., Kiefer, T., Wolff, D., Steiner, B., Hammer, U., Wegener, R., Kleine, H.D., Wilhelm, S., Knopp, A., Hartung, G., Dölken, G., Freund, M. Blood (2004) [Pubmed]
  6. Fludarabine and psoriasis. Smith, O.P., Hoffbrand, A.V., Buckley, C. N. Engl. J. Med. (1994) [Pubmed]
  7. 2-Chlorodeoxyadenosine for patients with B-cell chronic lymphocytic leukemia resistant to fludarabine. Saven, A., Lemon, R.H., Piro, L.D. N. Engl. J. Med. (1993) [Pubmed]
  8. 2-Chlorodeoxyadenosine for patients with B-cell chronic lymphocytic leukemia resistant to fludarabine. Delannoy, A., Hanique, G., Ferrant, A. N. Engl. J. Med. (1993) [Pubmed]
  9. Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling. Frank, D.A., Mahajan, S., Ritz, J. Nat. Med. (1999) [Pubmed]
  10. Lack of effect of 2-chlorodeoxyadenosine therapy in patients with chronic lymphocytic leukemia refractory to fludarabine therapy. O'Brien, S., Kantarjian, H., Estey, E., Koller, C., Robertson, B., Beran, M., Andreeff, M., Pierce, S., Keating, M. N. Engl. J. Med. (1994) [Pubmed]
  11. Infections in patients with chronic lymphocytic leukemia treated with fludarabine. Anaissie, E.J., Kontoyiannis, D.P., O'Brien, S., Kantarjian, H., Robertson, L., Lerner, S., Keating, M.J. Ann. Intern. Med. (1998) [Pubmed]
  12. Listeriosis in patients with chronic lymphocytic leukemia who were treated with fludarabine and prednisone. Anaissie, E., Kontoyiannis, D.P., Kantarjian, H., Elting, L., Robertson, L.E., Keating, M. Ann. Intern. Med. (1992) [Pubmed]
  13. Results of alemtuzumab-based reduced-intensity allogeneic transplantation for chronic lymphocytic leukemia: a British Society of Blood and Marrow Transplantation Study. Delgado, J., Thomson, K., Russell, N., Ewing, J., Stewart, W., Cook, G., Devereux, S., Lovell, R., Chopra, R., Marks, D.I., Mackinnon, S., Milligan, D.W. Blood (2006) [Pubmed]
  14. Once-daily intravenous busulfan and fludarabine: clinical and pharmacokinetic results of a myeloablative, reduced-toxicity conditioning regimen for allogeneic stem cell transplantation in AML and MDS. de Lima, M., Couriel, D., Thall, P.F., Wang, X., Madden, T., Jones, R., Shpall, E.J., Shahjahan, M., Pierre, B., Giralt, S., Korbling, M., Russell, J.A., Champlin, R.E., Andersson, B.S. Blood (2004) [Pubmed]
  15. Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or gamma radiation. Jones, D.T., Ganeshaguru, K., Virchis, A.E., Folarin, N.I., Lowdell, M.W., Mehta, A.B., Prentice, H.G., Hoffbrand, A.V., Wickremasinghe, R.G. Blood (2001) [Pubmed]
  16. Fludarabine increases oxaliplatin cytotoxicity in normal and chronic lymphocytic leukemia lymphocytes by suppressing interstrand DNA crosslink removal. Moufarij, M.A., Sampath, D., Keating, M.J., Plunkett, W. Blood (2006) [Pubmed]
  17. Durable engraftment of major histocompatibility complex-incompatible cells after nonmyeloablative conditioning with fludarabine, low-dose total body irradiation, and posttransplantation cyclophosphamide. Luznik, L., Jalla, S., Engstrom, L.W., Iannone, R., Fuchs, E.J. Blood (2001) [Pubmed]
  18. Differential roles of STAT1alpha and STAT1beta in fludarabine-induced cell cycle arrest and apoptosis in human B cells. Baran-Marszak, F., Feuillard, J., Najjar, I., Le Clorennec, C., Béchet, J.M., Dusanter-Fourt, I., Bornkamm, G.W., Raphaël, M., Fagard, R. Blood (2004) [Pubmed]
  19. Adaphostin-induced apoptosis in CLL B cells is associated with induction of oxidative stress and exhibits synergy with fludarabine. Shanafelt, T.D., Lee, Y.K., Bone, N.D., Strege, A.K., Narayanan, V.L., Sausville, E.A., Geyer, S.M., Kaufmann, S.H., Kay, N.E. Blood (2005) [Pubmed]
  20. Advances in the biology and treatment of B-cell chronic lymphocytic leukemia. O'Brien, S., del Giglio, A., Keating, M. Blood (1995) [Pubmed]
  21. Prior chemotherapy and allograft CD34+ dose impact donor engraftment following nonmyeloablative allogeneic stem cell transplantation in patients with solid tumors. Carvallo, C., Geller, N., Kurlander, R., Srinivasan, R., Mena, O., Igarashi, T., Griffith, L.M., Linehan, W.M., Childs, R.W. Blood (2004) [Pubmed]
  22. Rapid induction of complete donor chimerism by the use of a reduced-intensity conditioning regimen composed of fludarabine and melphalan in allogeneic stem cell transplantation for metastatic solid tumors. Ueno, N.T., Cheng, Y.C., Rondón, G., Tannir, N.M., Gajewski, J.L., Couriel, D.R., Hosing, C., de Lima, M.J., Anderlini, P., Khouri, I.F., Booser, D.J., Hortobagyi, G.N., Pagliaro, L.C., Jonasch, E., Giralt, S.A., Champlin, R.E. Blood (2003) [Pubmed]
  23. Long-term survival in refractory acute myeloid leukemia after sequential treatment with chemotherapy and reduced-intensity conditioning for allogeneic stem cell transplantation. Schmid, C., Schleuning, M., Schwerdtfeger, R., Hertenstein, B., Mischak-Weissinger, E., Bunjes, D., Harsdorf, S.V., Scheid, C., Holtick, U., Greinix, H., Keil, F., Schneider, B., Sandherr, M., Bug, G., Tischer, J., Ledderose, G., Hallek, M., Hiddemann, W., Kolb, H.J. Blood (2006) [Pubmed]
  24. Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells. Burger, M., Hartmann, T., Krome, M., Rawluk, J., Tamamura, H., Fujii, N., Kipps, T.J., Burger, J.A. Blood (2005) [Pubmed]
  25. MEK/ERK and signal transducer and activator of transcription signaling pathways modulate oncostatin M-stimulated CCL2 expression in human osteoblasts through a common transcription factor. Lin, S.K., Kok, S.H., Yeh, F.T., Kuo, M.Y., Lin, C.C., Wang, C.C., Goldring, S.R., Hong, C.Y. Arthritis Rheum. (2004) [Pubmed]
  26. Adenine deoxynucleotides fludarabine and cladribine induce apoptosis in a CD95/Fas receptor, FADD and caspase-8-independent manner by activation of the mitochondrial cell death pathway. Klöpfer, A., Hasenjäger, A., Belka, C., Schulze-Osthoff, K., Dörken, B., Daniel, P.T. Oncogene (2004) [Pubmed]
  27. Fludarabine induces apoptosis of human T-cell leukemia virus type 1-infected T cells via inhibition of the nuclear factor-kappaB signal pathway. Nishioka, C., Ikezoe, T., Yang, J., Koeffler, H.P., Taguchi, H. Leukemia (2007) [Pubmed]
  28. Fludarabine induces apoptosis, activation, and allogenicity in human endothelial and epithelial cells: protective effect of defibrotide. Eissner, G., Multhoff, G., Gerbitz, A., Kirchner, S., Bauer, S., Haffner, S., Sondermann, D., Andreesen, R., Holler, E. Blood (2002) [Pubmed]
  29. Stem cell transplantation with reduced-intensity conditioning for hemophagocytic lymphohistiocytosis. Cooper, N., Rao, K., Gilmour, K., Hadad, L., Adams, S., Cale, C., Davies, G., Webb, D., Veys, P., Amrolia, P. Blood (2006) [Pubmed]
  30. Long-term follow-up of patients with chronic lymphocytic leukemia treated with fludarabine as a single agent. Keating, M.J., O'Brien, S., Kantarjian, H., Plunkett, W., Estey, E., Koller, C., Beran, M., Freireich, E.J. Blood (1993) [Pubmed]
  31. Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia. Eichhorst, B.F., Busch, R., Hopfinger, G., Pasold, R., Hensel, M., Steinbrecher, C., Siehl, S., Jäger, U., Bergmann, M., Stilgenbauer, S., Schweighofer, C., Wendtner, C.M., Döhner, H., Brittinger, G., Emmerich, B., Hallek, M. Blood (2006) [Pubmed]
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