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Chemical Compound Review:

NSC-153182 3-[amino-[bis(2- chloroethyl)amino]phosphor...

Synonyms: NSC-227248, NSC153182, NSC227248, FT-0661475, NSC 153182, ...

Chan, K.K. et al., Hong, P.S. et al., Struck, R.F. et al.

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High impact information on NSC227248

The mean area under the plasma concentration curve (AUC) ratios between metabolites and CP were: 4-OH CP, 0.0158; PM, 0.4518; and chloroethyl oxazolidin-2-one, 0.179 with alcophosphamide at low levels [1].
CP, 4-OHCP, and other metabolites such as phosphoramide mustard, alcophosphamide, and 3-(2-chloroethyl)-1,3-oxazolidin-2-one in rat plasma were simultaneously analyzed using GC/MS and stable isotope dilution techniques [2].

Analytical, diagnostic and therapeutic context of NSC227248

Individual metabolites (4-hydroxy-CPA, 4-keto-CPA, alcophosphamide , dechloroethyl -CPA, carboxyphosphamide , and phosphoramide mustard) were isolated from blood by solvent extraction and by thin-layer chromatography [3].

References

Clinical pharmacokinetics of cyclophosphamide and metabolites with and without SR-2508. Chan, K.K., Hong, P.S., Tutsch, K., Trump, D.L. Cancer Res. (1994) [Pubmed]
Pharmacokinetics of 4-hydroxycyclophosphamide and metabolites in the rat. Hong, P.S., Srigritsanapol, A., Chan, K.K. Drug Metab. Dispos. (1991) [Pubmed]
Blood levels of alkylating metabolites of cyclophosphamide in the mouse after iv or oral administration. Struck, R.F., Alberts, D.S. Cancer treatment reports. (1984) [Pubmed]

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