The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

CCRIS 5126     3-[amino-[bis(2- chloroethyl)amino]phosphor...

Synonyms: AG-E-65554, Asta 5754, NSC-145124, AC1L1LRH, LS-76317, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on C07646


Biological context of C07646


Anatomical context of C07646


Analytical, diagnostic and therapeutic context of C07646

  • However, during high-dose chemotherapy, we observed a significant increase in the renal clearance of CP (15 v 23 mL/min; P < .01) and in the formation clearance of carboxyphosphamide (7 v 12 mL/min; P < .05) and dechloroethylCP (3.2 v 4.2 mL/min; P < .05), whereas metabolic clearance to ketoCP remained unchanged (1.3 v 1.2 mL/min) [9].


  1. Cyclophosphamide metabolism in children. Yule, S.M., Boddy, A.V., Cole, M., Price, L., Wyllie, R., Tasso, M.J., Pearson, A.D., Idle, J.R. Cancer Res. (1995) [Pubmed]
  2. Protection by transfected rat or human class 3 aldehyde dehydrogenase against the cytotoxic effects of oxazaphosphorine alkylating agents in hamster V79 cell lines. Demonstration of aldophosphamide metabolism by the human cytosolic class 3 isozyme. Bunting, K.D., Townsend, A.J. J. Biol. Chem. (1996) [Pubmed]
  3. Kinetic characterization of the catalysis of "activated" cyclophosphamide (4-hydroxycyclophosphamide/aldophosphamide) oxidation to carboxyphosphamide by mouse hepatic aldehyde dehydrogenases. Manthey, C.L., Sladek, N.E. Biochem. Pharmacol. (1988) [Pubmed]
  4. Relative contribution of human erythrocyte aldehyde dehydrogenase to the systemic detoxification of the oxazaphosphorines. Dockham, P.A., Sreerama, L., Sladek, N.E. Drug Metab. Dispos. (1997) [Pubmed]
  5. Urinary stability of carboxycyclophosphamide and carboxyifosfamide, two major metabolites of the anticancer drugs cyclophosphamide and ifosfamide. Joqueviel, C., Gilard, V., Martino, R., Malet-Martino, M., Niemeyer, U. Cancer Chemother. Pharmacol. (1997) [Pubmed]
  6. Influence of Aroclor 1254, phenobarbital, beta-naphthoflavone, and ethanol pretreatment on the biotransformation of cyclophosphamide in male and female rats. Sessink, P.J., Vaes, W.H., van den Broek, P.H., de Roos, J.H., Noordhoek, J., Bos, R.P. Toxicology (1996) [Pubmed]
  7. Carboxyphosphamide: NMR studies of its stability and cell membrane permeability. Ludeman, S.M., Ho, C.K., Boal, J.H., Sweet, E.M., Chang, Y.H. Drug Metab. Dispos. (1992) [Pubmed]
  8. Direct detection of the intracellular formation of carboxyphosphamides using nuclear magnetic resonance spectroscopy. Boal, J.H., Ludeman, S.M., Ho, C.K., Engel, J., Niemeyer, U. Arzneimittel-Forschung. (1994) [Pubmed]
  9. Dose escalation of cyclophosphamide in patients with breast cancer: consequences for pharmacokinetics and metabolism. Busse, D., Busch, F.W., Bohnenstengel, F., Eichelbaum, M., Fischer, P., Opalinska, J., Schumacher, K., Schweizer, E., Kroemer, H.K. J. Clin. Oncol. (1997) [Pubmed]
WikiGenes - Universities