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Chemical Compound Review

CCRIS 5126     3-[amino-[bis(2- chloroethyl)amino]phosphor...

Synonyms: AG-E-65554, Asta 5754, NSC-145124, AC1L1LRH, LS-76317, ...
 
 
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High impact information on C07646

 

Biological context of C07646

 

Anatomical context of C07646

 

Analytical, diagnostic and therapeutic context of C07646

  • However, during high-dose chemotherapy, we observed a significant increase in the renal clearance of CP (15 v 23 mL/min; P < .01) and in the formation clearance of carboxyphosphamide (7 v 12 mL/min; P < .05) and dechloroethylCP (3.2 v 4.2 mL/min; P < .05), whereas metabolic clearance to ketoCP remained unchanged (1.3 v 1.2 mL/min) [9].

References

  1. Cyclophosphamide metabolism in children. Yule, S.M., Boddy, A.V., Cole, M., Price, L., Wyllie, R., Tasso, M.J., Pearson, A.D., Idle, J.R. Cancer Res. (1995) [Pubmed]
  2. Protection by transfected rat or human class 3 aldehyde dehydrogenase against the cytotoxic effects of oxazaphosphorine alkylating agents in hamster V79 cell lines. Demonstration of aldophosphamide metabolism by the human cytosolic class 3 isozyme. Bunting, K.D., Townsend, A.J. J. Biol. Chem. (1996) [Pubmed]
  3. Kinetic characterization of the catalysis of "activated" cyclophosphamide (4-hydroxycyclophosphamide/aldophosphamide) oxidation to carboxyphosphamide by mouse hepatic aldehyde dehydrogenases. Manthey, C.L., Sladek, N.E. Biochem. Pharmacol. (1988) [Pubmed]
  4. Relative contribution of human erythrocyte aldehyde dehydrogenase to the systemic detoxification of the oxazaphosphorines. Dockham, P.A., Sreerama, L., Sladek, N.E. Drug Metab. Dispos. (1997) [Pubmed]
  5. Urinary stability of carboxycyclophosphamide and carboxyifosfamide, two major metabolites of the anticancer drugs cyclophosphamide and ifosfamide. Joqueviel, C., Gilard, V., Martino, R., Malet-Martino, M., Niemeyer, U. Cancer Chemother. Pharmacol. (1997) [Pubmed]
  6. Influence of Aroclor 1254, phenobarbital, beta-naphthoflavone, and ethanol pretreatment on the biotransformation of cyclophosphamide in male and female rats. Sessink, P.J., Vaes, W.H., van den Broek, P.H., de Roos, J.H., Noordhoek, J., Bos, R.P. Toxicology (1996) [Pubmed]
  7. Carboxyphosphamide: NMR studies of its stability and cell membrane permeability. Ludeman, S.M., Ho, C.K., Boal, J.H., Sweet, E.M., Chang, Y.H. Drug Metab. Dispos. (1992) [Pubmed]
  8. Direct detection of the intracellular formation of carboxyphosphamides using nuclear magnetic resonance spectroscopy. Boal, J.H., Ludeman, S.M., Ho, C.K., Engel, J., Niemeyer, U. Arzneimittel-Forschung. (1994) [Pubmed]
  9. Dose escalation of cyclophosphamide in patients with breast cancer: consequences for pharmacokinetics and metabolism. Busse, D., Busch, F.W., Bohnenstengel, F., Eichelbaum, M., Fischer, P., Opalinska, J., Schumacher, K., Schweizer, E., Kroemer, H.K. J. Clin. Oncol. (1997) [Pubmed]
 
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