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Gene Review:

CD24 - CD24 molecule

Homo sapiens

Synonyms: CD24A, Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen

Yang, X.R. et al., Liang, K.H., Carl, J.W. et al.

Kung-Hao Liang,

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Disease relevance of CD24

The role of CD24 in negative selection provides a novel explanation for its control of genetic susceptibility to autoimmune diseases in mice and humans [1].

Regulation of CD24

CD24 has antisense Alu elements in its 3'UTR region, making it susceptible to the regulation of other protein-coding RNAs with sense Alu elements, and Pol-III transcribed Alus [2].

Other interactions of CD24

High CD24 expression was significantly associated with cytoplasmic and nuclear accumulation of beta-catenin (P = 0.023), high tumor proliferative status (P = 0.018), and diffused intrahepatic recurrence and distant metastasis (P = 0.026) [3].

References

Autoreactive T cells escape clonal deletion in the thymus by a CD24-dependent pathway. Carl, J.W., Liu, J.Q., Joshi, P.S., El-Omrani, H.Y., Yin, L., Zheng, X., Whitacre, C.C., Liu, Y., Bai, X.F. J. Immunol. (2008) [Pubmed]
A gene expression restriction network mediated by sense and antisense Alu sequences located on protein-coding messenger RNAs. Liang, K.H., Yeh, C.T. BMC. Genomics. (2013) [Pubmed]
CD24 is a novel predictor for poor prognosis of hepatocellular carcinoma after surgery. Yang, X.R., Xu, Y., Yu, B., Zhou, J., Li, J.C., Qiu, S.J., Shi, Y.H., Wang, X.Y., Dai, Z., Shi, G.M., Wu, B., Wu, L.M., Yang, G.H., Zhang, B.H., Qin, W.X., Fan, J. Clin. Cancer Res. (2009) [Pubmed]

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