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MeSH Review

Autoimmune Diseases

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Disease relevance of Autoimmune Diseases


Psychiatry related information on Autoimmune Diseases


High impact information on Autoimmune Diseases

  • The pathogenic roles of B cells in autoimmune diseases occur through several mechanistic pathways that include autoantibodies, immune complexes, dendritic and T cell activation, cytokine synthesis, chemokine-mediated functions, and ectopic neolymphogenesis [11].
  • Disruption of the LT/TNF/LIGHT network alleviates inflammation in certain autoimmune disease models, but decreases resistance to selected pathogens [12].
  • IL-2 is necessary to destroy self-reactive lymphocytes and thus favors peripheral tolerance to self-antigens, whereas IL-15 favors the persistence of lymphocytes involved in the memory and effector responses to invading pathogens but risks the development of inflammatory autoimmune diseases [13].
  • Identifying Idd genes and defining their biologic functions should further our understanding of autoimmune disease pathogenesis and facilitate development of new treatments for diabetes [14].
  • Thus it may not be necessary to identify the target autoantigen to suppress an organ-specific autoimmune disease via oral tolerance; it is necessary only to administer orally a protein capable of inducing regulatory cells that secrete suppressive cytokines [15].

Chemical compound and disease context of Autoimmune Diseases


Biological context of Autoimmune Diseases


Anatomical context of Autoimmune Diseases


Gene context of Autoimmune Diseases


Analytical, diagnostic and therapeutic context of Autoimmune Diseases


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  2. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Takahashi, T., Tanaka, M., Brannan, C.I., Jenkins, N.A., Copeland, N.G., Suda, T., Nagata, S. Cell (1994) [Pubmed]
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  4. Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation. Demetriou, M., Granovsky, M., Quaggin, S., Dennis, J.W. Nature (2001) [Pubmed]
  5. A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells. Miyamoto, K., Miyake, S., Yamamura, T. Nature (2001) [Pubmed]
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  9. Toward localizing genes underlying cerebral asymmetry and mental health. Smalley, S.L., Loo, S.K., Yang, M.H., Cantor, R.M. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2005) [Pubmed]
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  15. Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Weiner, H.L., Friedman, A., Miller, A., Khoury, S.J., al-Sabbagh, A., Santos, L., Sayegh, M., Nussenblatt, R.B., Trentham, D.E., Hafler, D.A. Annu. Rev. Immunol. (1994) [Pubmed]
  16. Cyclosporine therapy for autoimmune disease. Fathman, C.G., Myers, B.D. N. Engl. J. Med. (1992) [Pubmed]
  17. Risk factors for cyclosporine-induced nephropathy in patients with autoimmune diseases. International Kidney Biopsy Registry of Cyclosporine in Autoimmune Diseases. Feutren, G., Mihatsch, M.J. N. Engl. J. Med. (1992) [Pubmed]
  18. Myelin basic protein as an encephalitogen in encephalomyelitis and polyneuritis following rabies vaccination. Hemachudha, T., Griffin, D.E., Giffels, J.J., Johnson, R.T., Moser, A.B., Phanuphak, P. N. Engl. J. Med. (1987) [Pubmed]
  19. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Youssef, S., Stüve, O., Patarroyo, J.C., Ruiz, P.J., Radosevich, J.L., Hur, E.M., Bravo, M., Mitchell, D.J., Sobel, R.A., Steinman, L., Zamvil, S.S. Nature (2002) [Pubmed]
  20. Autoimmunity in left-handers. Left-handedness may be associated with an increased risk of autoimmune disease. Is testosterone the link between the two? Marx, J.L. Science (1982) [Pubmed]
  21. An autosomal locus causing autoimmune disease: autoimmune polyglandular disease type I assigned to chromosome 21. Aaltonen, J., Björses, P., Sandkuijl, L., Perheentupa, J., Peltonen, L. Nat. Genet. (1994) [Pubmed]
  22. A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis. Helms, C., Cao, L., Krueger, J.G., Wijsman, E.M., Chamian, F., Gordon, D., Heffernan, M., Daw, J.A., Robarge, J., Ott, J., Kwok, P.Y., Menter, A., Bowcock, A.M. Nat. Genet. (2003) [Pubmed]
  23. Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity. Waisman, A., Ruiz, P.J., Hirschberg, D.L., Gelman, A., Oksenberg, J.R., Brocke, S., Mor, F., Cohen, I.R., Steinman, L. Nat. Med. (1996) [Pubmed]
  24. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Shull, M.M., Ormsby, I., Kier, A.B., Pawlowski, S., Diebold, R.J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D. Nature (1992) [Pubmed]
  25. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Monney, L., Sabatos, C.A., Gaglia, J.L., Ryu, A., Waldner, H., Chernova, T., Manning, S., Greenfield, E.A., Coyle, A.J., Sobel, R.A., Freeman, G.J., Kuchroo, V.K. Nature (2002) [Pubmed]
  26. Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Lang, K.S., Recher, M., Junt, T., Navarini, A.A., Harris, N.L., Freigang, S., Odermatt, B., Conrad, C., Ittner, L.M., Bauer, S., Luther, S.A., Uematsu, S., Akira, S., Hengartner, H., Zinkernagel, R.M. Nat. Med. (2005) [Pubmed]
  27. Positive selection in autoimmunity: abnormal immune responses to a bacterial dnaJ antigenic determinant in patients with early rheumatoid arthritis. Albani, S., Keystone, E.C., Nelson, J.L., Ollier, W.E., La Cava, A., Montemayor, A.C., Weber, D.A., Montecucco, C., Martini, A., Carson, D.A. Nat. Med. (1995) [Pubmed]
  28. Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice. Mokhtarian, F., McFarlin, D.E., Raine, C.S. Nature (1984) [Pubmed]
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  31. Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Yokoi, N., Komeda, K., Wang, H.Y., Yano, H., Kitada, K., Saitoh, Y., Seino, Y., Yasuda, K., Serikawa, T., Seino, S. Nat. Genet. (2002) [Pubmed]
  32. Requirement for CD154 in the progression of atherosclerosis. Lutgens, E., Gorelik, L., Daemen, M.J., de Muinck, E.D., Grewal, I.S., Koteliansky, V.E., Flavell, R.A. Nat. Med. (1999) [Pubmed]
  33. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Salomon, B., Lenschow, D.J., Rhee, L., Ashourian, N., Singh, B., Sharpe, A., Bluestone, J.A. Immunity (2000) [Pubmed]
  34. Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome. Salvador, J.M., Hollander, M.C., Nguyen, A.T., Kopp, J.B., Barisoni, L., Moore, J.K., Ashwell, J.D., Fornace, A.J. Immunity (2002) [Pubmed]
  35. Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis. Lider, O., Reshef, T., Beraud, E., Ben-Nun, A., Cohen, I.R. Science (1988) [Pubmed]
  36. Thymus and autoimmunity. Transplantation of the thymus from cyclosporin A-treated mice causes organ-specific autoimmune disease in athymic nude mice. Sakaguchi, S., Sakaguchi, N. J. Exp. Med. (1988) [Pubmed]
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