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Gene Review

PARP3  -  poly (ADP-ribose) polymerase family, member 3

Homo sapiens

Synonyms: ADP-ribosyltransferase diphtheria toxin-like 3, ADPRT-3, ADPRT3, ADPRTL2, ADPRTL3, ...
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High impact information on PARP3


Biological context of PARP3

  • Overexpression of hPARP-3 or its N-terminal domain does not influence centrosomal duplication or amplification but interferes with the G1/S cell cycle progression [1].

Analytical, diagnostic and therapeutic context of PARP3

  • By sequence analysis, we find that PARP-3 may be expressed in two isoforms which we studied in more detail to gain insight into their possible functions [3].
  • Through co-localization experiments and immunoprecipitations, the larger nuclear foci were identified as Polycomb group bodies (PcG bodies) and we found that PARP-3 is part of Polycomb group protein complexes [3].


  1. PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression. Augustin, A., Spenlehauer, C., Dumond, H., Ménissier-De Murcia, J., Piel, M., Schmit, A.C., Apiou, F., Vonesch, J.L., Kock, M., Bornens, M., De Murcia, G. J. Cell. Sci. (2003) [Pubmed]
  2. A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues. Johansson, M. Genomics (1999) [Pubmed]
  3. PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery. Rouleau, M., McDonald, D., Gagné, P., Ouellet, M.E., Droit, A., Hunter, J.M., Dutertre, S., Prigent, C., Hendzel, M.J., Poirier, G.G. J. Cell. Biochem. (2007) [Pubmed]
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