The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Centrioles


High impact information on Centrioles

  • Like tubulin, SAS-4 is incorporated into centrioles during their duplication and remains stably associated thereafter [4].
  • Electron microscopic immunocytochemistry localized this antigen in dense pericentriolar material (PCM) surrounding the centrioles [5].
  • In six dd4 cells subjected to serial sectioning centrioles were missing from one of the two poles [6].
  • Odf2-deficient mother centrioles lack distal/subdistal appendages and the ability to generate primary cilia [7].
  • The Polo kinase Plk4 functions in centriole duplication [8].

Biological context of Centrioles


Anatomical context of Centrioles

  • Epsilon-tubulin is required for centriole duplication and microtubule organization [13].
  • Outer dense fibre 2 (Odf2; also known as cenexin) was initially identified as a main component of the sperm tail cytoskeleton, but was later shown to be a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles [7].
  • Immunofluorescence with an anticentrosome serum and EM demonstrated that the MTOCs in cycloheximide-treated cells were typical centrosomes, containing centrioles and pericentriolar material [14].
  • In contrast, the antigen was not detected in preparations of soluble, cytoplasmic tubulin, which would not have contained tubulin from stable microtubule arrays such as centrioles, from unfertilized sea urchin eggs, Drosophila embryos, and HeLa cells [15].
  • By following the intracellular processing of recycling transferrin receptors and the selective sorting of a-2 macroglobulin in chick embryo fibroblasts, we have shown that the concentration of 60 nm diam tubules which surrounds the centrioles represents a distal compartment on the recycling pathway [16].

Associations of Centrioles with chemical compounds

  • Although clouds of PCM consistently form even when microtubules are completely disassembled by nocodazole, the centrioles are not assembled under these conditions [17].
  • Although the precise identity of the immunoreactive steroid substance has not yet been established, it seems noteworthy that exogenous steroids can be vitally concentrated by centrioles, perhaps by exchange with steroids already present at this level [18].
  • When these cells were exposed to microtubule reassembly buffer containing Triton X-100 and bovine brain tubulin at 37 degrees C, numerous microtubules were reassembled at all kinetochores of metaphase chromosomes and in association with centriole pairs [19].
  • Its partial localization to centrioles and basal bodies raises the possibility that purine compounds are involved in centriole replication and/or in the regulation of microtubule assembly in vivo [20].
  • We also demonstrate that PTN stimulates translocation of phosphoserine 713 and 726 beta-adducin either to nuclei, where it associates with nuclear chromatin and with centrioles of dividing cells, or to a membrane-associated site, depending on the phase of cell growth [21].

Gene context of Centrioles


Analytical, diagnostic and therapeutic context of Centrioles


  1. Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles. Forgues, M., Difilippantonio, M.J., Linke, S.P., Ried, T., Nagashima, K., Feden, J., Valerie, K., Fukasawa, K., Wang, X.W. Mol. Cell. Biol. (2003) [Pubmed]
  2. Morphological study of virus-like particles in two transplantable tumours from BDX rats. Calafat, J., Janssen, H., Kuzumaki, N. J. Gen. Virol. (1981) [Pubmed]
  3. Sex-linked ultrastructural dichotomy of gonadotroph adenomas of the human pituitary: an electron microscopic analysis of 145 tumors. Kontogeorgos, G., Horvath, E., Kovacs, K. Ultrastructural pathology. (1990) [Pubmed]
  4. SAS-4 is a C. elegans centriolar protein that controls centrosome size. Kirkham, M., Müller-Reichert, T., Oegema, K., Grill, S., Hyman, A.A. Cell (2003) [Pubmed]
  5. Centrosome development in early mouse embryos as defined by an autoantibody against pericentriolar material. Calarco-Gillam, P.D., Siebert, M.C., Hubble, R., Mitchison, T., Kirschner, M. Cell (1983) [Pubmed]
  6. Mutation of a Drosophila gamma tubulin ring complex subunit encoded by discs degenerate-4 differentially disrupts centrosomal protein localization. Barbosa, V., Yamamoto, R.R., Henderson, D.S., Glover, D.M. Genes Dev. (2000) [Pubmed]
  7. Odf2-deficient mother centrioles lack distal/subdistal appendages and the ability to generate primary cilia. Ishikawa, H., Kubo, A., Tsukita, S., Tsukita, S. Nat. Cell Biol. (2005) [Pubmed]
  8. The Polo kinase Plk4 functions in centriole duplication. Habedanck, R., Stierhof, Y.D., Wilkinson, C.J., Nigg, E.A. Nat. Cell Biol. (2005) [Pubmed]
  9. Primary cilia of human endothelial cells disassemble under laminar shear stress. Iomini, C., Tejada, K., Mo, W., Vaananen, H., Piperno, G. J. Cell Biol. (2004) [Pubmed]
  10. Centriole cycle in Chinese hamster ovary cells as determined by whole-mount electron microscopy. Kuriyama, R., Borisy, G.G. J. Cell Biol. (1981) [Pubmed]
  11. Ribonucleoprotein staining of centrioles and kinetochores in newt lung cell spindles. Rieder, C.L. J. Cell Biol. (1979) [Pubmed]
  12. Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication. Zou, C., Li, J., Bai, Y., Gunning, W.T., Wazer, D.E., Band, V., Gao, Q. J. Cell Biol. (2005) [Pubmed]
  13. Epsilon-tubulin is required for centriole duplication and microtubule organization. Chang, P., Giddings, T.H., Winey, M., Stearns, T. Nat. Cell Biol. (2003) [Pubmed]
  14. Centrosome duplication continues in cycloheximide-treated Xenopus blastulae in the absence of a detectable cell cycle. Gard, D.L., Hafezi, S., Zhang, T., Doxsey, S.J. J. Cell Biol. (1990) [Pubmed]
  15. Monoclonal antibodies specific for an acetylated form of alpha-tubulin recognize the antigen in cilia and flagella from a variety of organisms. Piperno, G., Fuller, M.T. J. Cell Biol. (1985) [Pubmed]
  16. In migrating fibroblasts, recycling receptors are concentrated in narrow tubules in the pericentriolar area, and then routed to the plasma membrane of the leading lamella. Hopkins, C.R., Gibson, A., Shipman, M., Strickland, D.K., Trowbridge, I.S. J. Cell Biol. (1994) [Pubmed]
  17. De novo formation of centrosomes in vertebrate cells arrested during S phase. Khodjakov, A., Rieder, C.L., Sluder, G., Cassels, G., Sibon, O., Wang, C.L. J. Cell Biol. (2002) [Pubmed]
  18. Concerning the localization of steroids in centrioles and basal bodies by immunofluorescence. Nenci, I., Marchetti, E. J. Cell Biol. (1978) [Pubmed]
  19. Human chromosomes and centrioles as nucleating sites for the in vitro assembly of microtubules from bovine brain tubulin. McGill, M., Brinkley, B.R. J. Cell Biol. (1975) [Pubmed]
  20. Purine nucleoside phosphorylase is associated with centrioles and basal bodies. Oliver, J.M., Osborne, W.R., Pfeiffer, J.R., Child, F.M., Berlin, R.D. J. Cell Biol. (1981) [Pubmed]
  21. Pleiotrophin regulates serine phosphorylation and the cellular distribution of beta-adducin through activation of protein kinase C. Pariser, H., Herradon, G., Ezquerra, L., Perez-Pinera, P., Deuel, T.F. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  22. NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly. Haren, L., Remy, M.H., Bazin, I., Callebaut, I., Wright, M., Merdes, A. J. Cell Biol. (2006) [Pubmed]
  23. RPGR ORF15 isoform co-localizes with RPGRIP1 at centrioles and basal bodies and interacts with nucleophosmin. Shu, X., Fry, A.M., Tulloch, B., Manson, F.D., Crabb, J.W., Khanna, H., Faragher, A.J., Lennon, A., He, S., Trojan, P., Giessl, A., Wolfrum, U., Vervoort, R., Swaroop, A., Wright, A.F. Hum. Mol. Genet. (2005) [Pubmed]
  24. The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles. Guarguaglini, G., Duncan, P.I., Stierhof, Y.D., Holmström, T., Duensing, S., Nigg, E.A. Mol. Biol. Cell (2005) [Pubmed]
  25. Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer. Weaver, Z., Montagna, C., Xu, X., Howard, T., Gadina, M., Brodie, S.G., Deng, C.X., Ried, T. Oncogene (2002) [Pubmed]
  26. Cyclin-dependent kinase inhibitor indirubin-3'-oxime selectively inhibits human papillomavirus type 16 E7-induced numerical centrosome anomalies. Duensing, S., Duensing, A., Lee, D.C., Edwards, K.M., Piboonniyom, S.O., Manuel, E., Skaltsounis, L., Meijer, L., Münger, K. Oncogene (2004) [Pubmed]
  27. Variations in the distribution and migration of centriole duplexes in mitotic PtK2 cells studied by immunofluorescence microscopy. Aubin, J.E., Osborn, M., Weber, K. J. Cell. Sci. (1980) [Pubmed]
  28. Demonstration of kinetochores and centrioles in spermatocytes of two species of cockroaches by silver staining. Shi, L., Pathak, S., Hsu, T.C. Chromosoma (1982) [Pubmed]
WikiGenes - Universities