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Gene Review

ARPC4  -  actin related protein 2/3 complex, subunit...

Homo sapiens

Synonyms: ARC20, Actin-related protein 2/3 complex subunit 4, Arp2/3 complex 20 kDa subunit, P20-ARC, p20-ARC, ...
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High impact information on ARPC4

  • Subunits ARPC2 p34 and ARPC4 p20 in the core of the complex associate through long carboxyl-terminal alpha helices and have similarly folded amino-terminal alpha/beta domains [1].
  • The ARC20 was achieved by 22 (73%) of etanercept-treated patients compared with four (13%) of placebo-treated patients [2].
  • In contrast, p41-Arc only interacted with p20-Arc/p16-Arc heterodimer [3].
  • Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub [3].


  1. Crystal structure of Arp2/3 complex. Robinson, R.C., Turbedsky, K., Kaiser, D.A., Marchand, J.B., Higgs, H.N., Choe, S., Pollard, T.D. Science (2001) [Pubmed]
  2. Etanercept in the treatment of psoriatic arthritis and psoriasis: a randomised trial. Mease, P.J., Goffe, B.S., Metz, J., VanderStoep, A., Finck, B., Burge, D.J. Lancet (2000) [Pubmed]
  3. Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub. Zhao, X., Yang, Z., Qian, M., Zhu, X. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
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