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Gene Review:

ARPC5 - actin related protein 2/3 complex, subunit...

Homo sapiens

Synonyms: ARC16, Actin-related protein 2/3 complex subunit 5, Arp2/3 complex 16 kDa subunit, dJ127C7.3, p16-ARC, ...

Singh, S. et al., Millard, T.H. et al., Zhao, X. et al., Robinson, R.C. et al.

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High impact information on ARPC5

ARPC3 p21 and ARPC5 p16 are globular alpha-helical subunits [1].
7. MAPKAPK2 also phosphorylated p16-Arc in intact Arp2/3 complexes precipitated from neutrophil lysates [2].
The presence of both ARPC5 isoforms was detected in Arp2/3 complex affinity purified from human neutrophil extract [3].
In contrast, p41-Arc only interacted with p20-Arc/p16-Arc heterodimer [4].

Physical interactions of ARPC5

Identification of the p16-Arc subunit of the Arp 2/3 complex as a substrate of MAPK-activated protein kinase 2 by proteomic analysis [2].

Other interactions of ARPC5

In vitro studies confirmed that MAPKAPK2 interacts with and phosphorylates the A isoform, but not the B isoform, of p16-Arc with a stoichiometry of 0.6 to 0 [2].

References

Crystal structure of Arp2/3 complex. Robinson, R.C., Turbedsky, K., Kaiser, D.A., Marchand, J.B., Higgs, H.N., Choe, S., Pollard, T.D. Science (2001) [Pubmed]
Identification of the p16-Arc subunit of the Arp 2/3 complex as a substrate of MAPK-activated protein kinase 2 by proteomic analysis. Singh, S., Powell, D.W., Rane, M.J., Millard, T.H., Trent, J.O., Pierce, W.M., Klein, J.B., Machesky, L.M., McLeish, K.R. J. Biol. Chem. (2003) [Pubmed]
Identification and characterisation of a novel human isoform of Arp2/3 complex subunit p16-ARC/ARPC5. Millard, T.H., Behrendt, B., Launay, S., Fütterer, K., Machesky, L.M. Cell Motil. Cytoskeleton (2003) [Pubmed]
Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub. Zhao, X., Yang, Z., Qian, M., Zhu, X. Biochem. Biophys. Res. Commun. (2001) [Pubmed]

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