Gene Review:
ACTR2 - ARP2 actin-related protein 2 homolog (yeast)
Homo sapiens
Synonyms:
ARP2, Actin-like protein 2, Actin-related protein 2
DeMali,
Barlow,
Burridge,
Falet,
Hoffmeister,
Neujahr,
Hartwig,
Carlier,
Nioche,
Broutin-L'Hermite,
Boujemaa,
Le Clainche,
Egile,
Garbay,
Ducruix,
Sansonetti,
Pantaloni,
Komano,
Miyauchi,
Matsuda,
Yamamoto,
dos Remedios,
Chhabra,
Kekic,
Dedova,
Tsubakihara,
Berry,
Nosworthy,
Higgs,
Pollard,
- Actin-related protein 2/3 complex is required for actin ring formation. Hurst, I.R., Zuo, J., Jiang, J., Holliday, L.S. J. Bone Miner. Res. (2004)
- Reconstitution of actin-based motility of Listeria and Shigella using pure proteins. Loisel, T.P., Boujemaa, R., Pantaloni, D., Carlier, M.F. Nature (1999)
- IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. Miki, H., Yamaguchi, H., Suetsugu, S., Takenawa, T. Nature (2000)
- Inhibiting the Arp2/3 complex limits infection of both intracellular mature vaccinia virus and primate lentiviruses. Komano, J., Miyauchi, K., Matsuda, Z., Yamamoto, N. Mol. Biol. Cell (2004)
- Regulation of actin filament network formation through ARP2/3 complex: activation by a diverse array of proteins. Higgs, H.N., Pollard, T.D. Annu. Rev. Biochem. (2001)
- Actin binding proteins: regulation of cytoskeletal microfilaments. dos Remedios, C.G., Chhabra, D., Kekic, M., Dedova, I.V., Tsubakihara, M., Berry, D.A., Nosworthy, N.J. Physiol. Rev. (2003)
- Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia. Devriendt, K., Kim, A.S., Mathijs, G., Frints, S.G., Schwartz, M., Van Den Oord, J.J., Verhoef, G.E., Boogaerts, M.A., Fryns, J.P., You, D., Rosen, M.K., Vandenberghe, P. Nat. Genet. (2001)
- Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins. Blanchoin, L., Amann, K.J., Higgs, H.N., Marchand, J.B., Kaiser, D.A., Pollard, T.D. Nature (2000)
- Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinomas with chromosome 11q13 amplification. Rothschild, B.L., Shim, A.H., Ammer, A.G., Kelley, L.C., Irby, K.B., Head, J.A., Chen, L., Varella-Garcia, M., Sacks, P.G., Frederick, B., Raben, D., Weed, S.A. Cancer Res. (2006)
- A conserved amphipathic helix in WASP/Scar proteins is essential for activation of Arp2/3 complex. Panchal, S.C., Kaiser, D.A., Torres, E., Pollard, T.D., Rosen, M.K. Nat. Struct. Biol. (2003)
- A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton. Lynch, D.K., Winata, S.C., Lyons, R.J., Hughes, W.E., Lehrbach, G.M., Wasinger, V., Corthals, G., Cordwell, S., Daly, R.J. J. Biol. Chem. (2003)
- A neural Wiskott-Aldrich Syndrome protein-mediated pathway for localized activation of actin polymerization that is regulated by cortactin. Kempiak, S.J., Yamaguchi, H., Sarmiento, C., Sidani, M., Ghosh, M., Eddy, R.J., Desmarais, V., Way, M., Condeelis, J., Segall, J.E. J. Biol. Chem. (2005)
- Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion. DeMali, K.A., Barlow, C.A., Burridge, K. J. Cell Biol. (2002)
- IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization. Schmidt, V.A., Scudder, L., Devoe, C.E., Bernards, A., Cupit, L.D., Bahou, W.F. Blood (2003)
- WAVE/Scars in platelets. Oda, A., Miki, H., Wada, I., Yamaguchi, H., Yamazaki, D., Suetsugu, S., Nakajima, M., Nakayama, A., Okawa, K., Miyazaki, H., Matsuno, K., Ochs, H.D., Machesky, L.M., Fujita, H., Takenawa, T. Blood (2005)
- Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex. Higgs, H.N., Pollard, T.D. J. Cell Biol. (2000)
- Normal Arp2/3 complex activation in platelets lacking WASp. Falet, H., Hoffmeister, K.M., Neujahr, R., Hartwig, J.H. Blood (2002)
- GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex. Carlier, M.F., Nioche, P., Broutin-L'Hermite, I., Boujemaa, R., Le Clainche, C., Egile, C., Garbay, C., Ducruix, A., Sansonetti, P., Pantaloni, D. J. Biol. Chem. (2000)
- Arp2/3 complex is required for actin polymerization during platelet shape change. Li, Z., Kim, E.S., Bearer, E.L. Blood (2002)
- Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization. Higgs, H.N., Blanchoin, L., Pollard, T.D. Biochemistry (1999)
- Activation of the Arp2/3 complex by the Listeria acta protein. Acta binds two actin monomers and three subunits of the Arp2/3 complex. Zalevsky, J., Grigorova, I., Mullins, R.D. J. Biol. Chem. (2001)
- Involvement of Arp2/3 complex in MCP-1-induced chemotaxis. Mukai, Y., Iwaya, K., Ogawa, H., Mukai, K. Biochem. Biophys. Res. Commun. (2005)
- Integration of signals to the Arp2/3 complex. Weaver, A.M., Young, M.E., Lee, W.L., Cooper, J.A. Curr. Opin. Cell Biol. (2003)
- Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex. Marchand, J.B., Kaiser, D.A., Pollard, T.D., Higgs, H.N. Nat. Cell Biol. (2001)
- The coiled-coil domain is required for HS1 to bind to F-actin and activate Arp2/3 complex. Hao, J.J., Zhu, J., Zhou, K., Smith, N., Zhan, X. J. Biol. Chem. (2005)
- Grb2 and Nck act cooperatively to promote actin-based motility of vaccinia virus. Scaplehorn, N., Holmström, A., Moreau, V., Frischknecht, F., Reckmann, I., Way, M. Curr. Biol. (2002)
- Interaction of cortactin and Arp2/3 complex is required for sphingosine-1-phosphate-induced endothelial cell remodeling. Li, Y., Uruno, T., Haudenschild, C., Dudek, S.M., Garcia, J.G., Zhan, X. Exp. Cell Res. (2004)
- Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex. Prehoda, K.E., Scott, J.A., Mullins, R.D., Lim, W.A. Science (2000)