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Gene Review

CDH12  -  cadherin 12, type 2 (N-cadherin 2)

Homo sapiens

Synonyms: BR-cadherin, Br-cadherin, Brain cadherin, CDHB, Cadherin-12, ...
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Disease relevance of CDH12


High impact information on CDH12

  • Although the Br-cadherin protein is confined to the central nervous system, its mRNA is present in several additional tissues, suggesting that there is posttranscriptional control of this gene's expression [2].
  • We show that this repeated sequence, named c41-cad, is a highly expressed pseudogene derived from an intact neuronal cadherin gene, Br-cadherin, situated on 5p13-14 [3].
  • A rationally designed ZON analogue, cyclododecyl 2,4-dihydroxybenzoate (CDHB), that exhibits resemblance to ZON in terms of size, shape and functionality has been synthesized and used as template for MIP preparation instead of the natural toxin [4].
  • The comparison also provides additional evidence for two structurally different types of cadherins: the first type includes B-, E-, EP-, M, N-, P- and R-cadherins and cadherin-4; the second type includes cadherin-5 through cadherin-12 [5].


  1. Ras association domain family 1C protein stimulates human lung cancer cell proliferation. Amaar, Y.G., Minera, M.G., Hatran, L.K., Strong, D.D., Mohan, S., Reeves, M.E. Am. J. Physiol. Lung Cell Mol. Physiol. (2006) [Pubmed]
  2. Molecular characterization of Br-cadherin, a developmentally regulated, brain-specific cadherin. Selig, S., Lidov, H.G., Bruno, S.A., Segal, M.M., Kunkel, L.M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  3. Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene. Selig, S., Bruno, S., Scharf, J.M., Wang, C.H., Vitale, E., Gilliam, T.C., Kunkel, L.M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  4. Molecularly imprinted polymers with a streamlined mimic for zearalenone analysis. Urraca, J.L., Marazuela, M.D., Merino, E.R., Orellana, G., Moreno-Bondi, M.C. Journal of chromatography. A. (2006) [Pubmed]
  5. Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin. Tanihara, H., Sano, K., Heimark, R.L., St John, T., Suzuki, S. Cell Adhes. Commun. (1994) [Pubmed]
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