Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

CDH12 - cadherin 12, type 2 (N-cadherin 2)

Homo sapiens

Synonyms: BR-cadherin, Br-cadherin, Brain cadherin, CDHB, Cadherin-12, ...

Urraca, J.L. et al., Tanihara, H. et al., Selig, S. et al., Selig, S. et al., Amaar, Y.G. et al.

Amaar, Minera, Hatran, Strong, Mohan, Reeves,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CDH12

Finally, we found that RASSF1C, unlike RASSF1A, does not upregulate N-cadherin 2 and transglutaminase 2 protein expression in NCI H1299 lung cancer cells [1].

High impact information on CDH12

Although the Br-cadherin protein is confined to the central nervous system, its mRNA is present in several additional tissues, suggesting that there is posttranscriptional control of this gene's expression [2].
We show that this repeated sequence, named c41-cad, is a highly expressed pseudogene derived from an intact neuronal cadherin gene, Br-cadherin, situated on 5p13-14 [3].
A rationally designed ZON analogue, cyclododecyl 2,4-dihydroxybenzoate (CDHB), that exhibits resemblance to ZON in terms of size, shape and functionality has been synthesized and used as template for MIP preparation instead of the natural toxin [4].
The comparison also provides additional evidence for two structurally different types of cadherins: the first type includes B-, E-, EP-, M, N-, P- and R-cadherins and cadherin-4; the second type includes cadherin-5 through cadherin-12 [5].

References

Ras association domain family 1C protein stimulates human lung cancer cell proliferation. Amaar, Y.G., Minera, M.G., Hatran, L.K., Strong, D.D., Mohan, S., Reeves, M.E. Am. J. Physiol. Lung Cell Mol. Physiol. (2006) [Pubmed]
Molecular characterization of Br-cadherin, a developmentally regulated, brain-specific cadherin. Selig, S., Lidov, H.G., Bruno, S.A., Segal, M.M., Kunkel, L.M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene. Selig, S., Bruno, S., Scharf, J.M., Wang, C.H., Vitale, E., Gilliam, T.C., Kunkel, L.M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
Molecularly imprinted polymers with a streamlined mimic for zearalenone analysis. Urraca, J.L., Marazuela, M.D., Merino, E.R., Orellana, G., Moreno-Bondi, M.C. Journal of chromatography. A. (2006) [Pubmed]
Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin. Tanihara, H., Sano, K., Heimark, R.L., St John, T., Suzuki, S. Cell Adhes. Commun. (1994) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

CDH12	Bos taurus
CDH12	Canis lupus familiaris
cdh12a	Danio rerio
CDH12	Gallus gallus
CDH12	Macaca mulatta
Cdh12	Mus musculus
CDH12	Pan troglodytes
Cdh12	Rattus norvegicus
cdh12	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.