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Gene Review

CDH5  -  cadherin 5, type 2 (vascular endothelium)

Homo sapiens

Synonyms: 7B4, 7B4 antigen, CD144, Cadherin-5, VE-cadherin, ...
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Disease relevance of CDH5


High impact information on CDH5

  • Here, targeted inactivation (VEC-/-) or truncation of the beta-catenin-binding cytosolic domain (VECdeltaC/deltaC) of the VE-cadherin gene was found not to affect assembly of endothelial cells in vascular plexi, but to impair their subsequent remodeling and maturation, causing lethality at 9.5 days of gestation [5].
  • Our findings conclude that the interplay of fibrin fragments, leukocytes and VE-cadherin contribute to the pathogenesis of myocardial damage and reperfusion injury [6].
  • Here, we identify a subpopulation of primitive endothelial-like cells derived from human embryonic stem cells (hESCs) that express PECAM-1, Flk-1, and VE-cadherin, but not CD45 (CD45negPFV cells), and that are uniquely responsible for endothelial and hematopoietic development [7].
  • Together, through modulation of endothelial contractility and VE-cadherin-mediated adhesion, JAM-C helps to regulate vascular permeability and pathologic angiogenesis [8].
  • Both biochemical and indirect immunofluorescence analyses of the adherens junction zone of EC monolayers revealed that neutrophil adhesion, not transmigration, induced disruption of the VE-cadherin complex and loss of its lateral junction localization [9].

Chemical compound and disease context of CDH5


Biological context of CDH5


Anatomical context of CDH5


Associations of CDH5 with chemical compounds


Physical interactions of CDH5


Co-localisations of CDH5


Regulatory relationships of CDH5


Other interactions of CDH5


Analytical, diagnostic and therapeutic context of CDH5


  1. Epithelioid sarcoma: presence of vascular-endothelial cadherin and lack of epithelial cadherin. Smith, M.E., Brown, J.I., Fisher, C. Histopathology (1998) [Pubmed]
  2. Transference of recombinant VE-cadherin cytoplasmic domain alters endothelial junctional integrity and porcine microvascular permeability. Guo, M., Wu, M.H., Granger, H.J., Yuan, S.Y. J. Physiol. (Lond.) (2004) [Pubmed]
  3. Assessing microvessels and angiogenesis in human breast cancer, using VE-cadherin. Martin, T.A., Watkins, G., Lane, J., Jiang, W.G. Histopathology (2005) [Pubmed]
  4. Elevated concentration of soluble vascular endothelial cadherin is associated with coronary atherosclerosis. Soeki, T., Tamura, Y., Shinohara, H., Sakabe, K., Onose, Y., Fukuda, N. Circ. J. (2004) [Pubmed]
  5. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Carmeliet, P., Lampugnani, M.G., Moons, L., Breviario, F., Compernolle, V., Bono, F., Balconi, G., Spagnuolo, R., Oostuyse, B., Dewerchin, M., Zanetti, A., Angellilo, A., Mattot, V., Nuyens, D., Lutgens, E., Clotman, F., de Ruiter, M.C., Gittenberger-de Groot, A., Poelmann, R., Lupu, F., Herbert, J.M., Collen, D., Dejana, E. Cell (1999) [Pubmed]
  6. The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury. Petzelbauer, P., Zacharowski, P.A., Miyazaki, Y., Friedl, P., Wickenhauser, G., Castellino, F.J., Gröger, M., Wolff, K., Zacharowski, K. Nat. Med. (2005) [Pubmed]
  7. Endothelial and hematopoietic cell fate of human embryonic stem cells originates from primitive endothelium with hemangioblastic properties. Wang, L., Li, L., Shojaei, F., Levac, K., Cerdan, C., Menendez, P., Martin, T., Rouleau, A., Bhatia, M. Immunity (2004) [Pubmed]
  8. Junctional adhesion molecule-C regulates vascular endothelial permeability by modulating VE-cadherin-mediated cell-cell contacts. Orlova, V.V., Economopoulou, M., Lupu, F., Santoso, S., Chavakis, T. J. Exp. Med. (2006) [Pubmed]
  9. Endothelial-dependent mechanisms regulate leukocyte transmigration: a process involving the proteasome and disruption of the vascular endothelial-cadherin complex at endothelial cell-to-cell junctions. Allport, J.R., Ding, H., Collins, T., Gerritsen, M.E., Luscinskas, F.W. J. Exp. Med. (1997) [Pubmed]
  10. Effects of cytotoxic necrotizing factor 1 and lethal toxin on actin cytoskeleton and VE-cadherin localization in human endothelial cell monolayers. Vouret-Craviari, V., Grall, D., Flatau, G., Pouysségur, J., Boquet, P., Van Obberghen-Schilling, E. Infect. Immun. (1999) [Pubmed]
  11. Paracrine VEGF/VE-Cadherin Action on Ovarian Cancer Permeability. Hu, L., Ferrara, N., Jaffe, R.B. Exp. Biol. Med. (Maywood) (2006) [Pubmed]
  12. Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway. Fukuhara, S., Sakurai, A., Sano, H., Yamagishi, A., Somekawa, S., Takakura, N., Saito, Y., Kangawa, K., Mochizuki, N. Mol. Cell. Biol. (2005) [Pubmed]
  13. SHP2 association with VE-cadherin complexes in human endothelial cells is regulated by thrombin. Ukropec, J.A., Hollinger, M.K., Salva, S.M., Woolkalis, M.J. J. Biol. Chem. (2000) [Pubmed]
  14. Laminar shear stress differentially modulates gene expression of p120 catenin, Kaiso transcription factor, and vascular endothelial cadherin in human coronary artery endothelial cells. Kondapalli, J., Flozak, A.S., Albuquerque, M.L. J. Biol. Chem. (2004) [Pubmed]
  15. Catenin-dependent and -independent functions of vascular endothelial cadherin. Navarro, P., Caveda, L., Breviario, F., Mândoteanu, I., Lampugnani, M.G., Dejana, E. J. Biol. Chem. (1995) [Pubmed]
  16. VE-cadherin-induced Cdc42 signaling regulates formation of membrane protrusions in endothelial cells. Kouklis, P., Konstantoulaki, M., Malik, A.B. J. Biol. Chem. (2003) [Pubmed]
  17. Functional roles for PECAM-1 (CD31) and VE-cadherin (CD144) in tube assembly and lumen formation in three-dimensional collagen gels. Yang, S., Graham, J., Kahn, J.W., Schwartz, E.A., Gerritsen, M.E. Am. J. Pathol. (1999) [Pubmed]
  18. Mechanisms of VE-cadherin processing and degradation in microvascular endothelial cells. Xiao, K., Allison, D.F., Kottke, M.D., Summers, S., Sorescu, G.P., Faundez, V., Kowalczyk, A.P. J. Biol. Chem. (2003) [Pubmed]
  19. Inhibition of vascular endothelial growth factor-induced angiogenesis by resveratrol through interruption of Src-dependent vascular endothelial cadherin tyrosine phosphorylation. Lin, M.T., Yen, M.L., Lin, C.Y., Kuo, M.L. Mol. Pharmacol. (2003) [Pubmed]
  20. Dynamics of vascular endothelial-cadherin and beta-catenin localization by vascular endothelial growth factor-induced angiogenesis in human umbilical vein cells. Wright, T.J., Leach, L., Shaw, P.E., Jones, P. Exp. Cell Res. (2002) [Pubmed]
  21. Interaction of fibrin(ogen) with the endothelial cell receptor VE-cadherin: mapping of the receptor-binding site in the NH2-terminal portions of the fibrin beta chains. Gorlatov, S., Medved, L. Biochemistry (2002) [Pubmed]
  22. Gingipains from Porphyromonas gingivalis W83 induce cell adhesion molecule cleavage and apoptosis in endothelial cells. Sheets, S.M., Potempa, J., Travis, J., Casiano, C.A., Fletcher, H.M. Infect. Immun. (2005) [Pubmed]
  23. ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration. Allingham, M.J., van Buul, J.D., Burridge, K. J. Immunol. (2007) [Pubmed]
  24. Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site. Wallez, Y., Cand, F., Cruzalegui, F., Wernstedt, C., Souchelnytskyi, S., Vilgrain, I., Huber, P. Oncogene (2007) [Pubmed]
  25. The Armadillo family protein p0071 is a VE-cadherin- and desmoplakin-binding protein. Calkins, C.C., Hoepner, B.L., Law, C.M., Novak, M.R., Setzer, S.V., Hatzfeld, M., Kowalczyk, A.P. J. Biol. Chem. (2003) [Pubmed]
  26. Desmoplakin expression and organization at human umbilical vein endothelial cell-to-cell junctions. Valiron, O., Chevrier, V., Usson, Y., Breviario, F., Job, D., Dejana, E. J. Cell. Sci. (1996) [Pubmed]
  27. Tyrosine phosphorylation of VE-cadherin prevents binding of p120- and beta-catenin and maintains the cellular mesenchymal state. Potter, M.D., Barbero, S., Cheresh, D.A. J. Biol. Chem. (2005) [Pubmed]
  28. IQGAP1 mediates VE-cadherin-based cell-cell contacts and VEGF signaling at adherence junctions linked to angiogenesis. Yamaoka-Tojo, M., Tojo, T., Kim, H.W., Hilenski, L., Patrushev, N.A., Zhang, L., Fukai, T., Ushio-Fukai, M. Arterioscler. Thromb. Vasc. Biol. (2006) [Pubmed]
  29. Molecular organization of tight and adherens junctions in the human placental vascular tree. Leach, L., Lammiman, M.J., Babawale, M.O., Hobson, S.A., Bromilou, B., Lovat, S., Simmonds, M.J. Placenta (2000) [Pubmed]
  30. TNF-{alpha} increases tyrosine phosphorylation of vascular endothelial cadherin and opens the paracellular pathway through fyn activation in human lung endothelia. Angelini, D.J., Hyun, S.W., Grigoryev, D.N., Garg, P., Gong, P., Singh, I.S., Passaniti, A., Hasday, J.D., Goldblum, S.E. Am. J. Physiol. Lung Cell Mol. Physiol. (2006) [Pubmed]
  31. p120-Catenin regulates clathrin-dependent endocytosis of VE-cadherin. Xiao, K., Garner, J., Buckley, K.M., Vincent, P.A., Chiasson, C.M., Dejana, E., Faundez, V., Kowalczyk, A.P. Mol. Biol. Cell (2005) [Pubmed]
  32. Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells. Esser, S., Lampugnani, M.G., Corada, M., Dejana, E., Risau, W. J. Cell. Sci. (1998) [Pubmed]
  33. Vascular-endothelial cadherin (CD144)- but not PECAM-1 (CD31)-based cell-to-cell contacts convey the maintenance of a quiescent endothelial monolayer. Halama, T., Staffler, G., Hoch, S., Stockinger, H., Wolff, K., Petzelbauer, P. Int. Arch. Allergy Immunol. (1999) [Pubmed]
  34. Cell junctional proteins in the human corpus luteum: changes during the normal cycle and after HCG treatment. Groten, T., Fraser, H.M., Duncan, W.C., Konrad, R., Kreienberg, R., Wulff, C. Hum. Reprod. (2006) [Pubmed]
  35. VE-Cadherin mediates endothelial cell capillary tube formation in fibrin and collagen gels. Bach, T.L., Barsigian, C., Chalupowicz, D.G., Busler, D., Yaen, C.H., Grant, D.S., Martinez, J. Exp. Cell Res. (1998) [Pubmed]
  36. The role of p38 map kinase in tumor necrosis factor-induced redistribution of vascular endothelial cadherin and increased endothelial permeability. Nwariaku, F.E., Chang, J., Zhu, X., Liu, Z., Duffy, S.L., Halaihel, N.H., Terada, L., Turnage, R.H. Shock (2002) [Pubmed]
  37. Identification and characterization of two genes (MIP-1beta, VE-CADHERIN) implicated in acute rejection in human heart transplantation: use of murine models in tandem with cDNA arrays. Roussoulières, A.L., Raisky, O., Chalabreysse, L., Dureau, G., Cerutti, C., Thieblemont, C., Boissonnat, P., Sebbag, L., Obadia, J.F., Ninet, J., Bastien, O., Thivolet-Bejui, F., McGregor, J.L. Circulation (2005) [Pubmed]
  38. Characterization of cytoskeletal and junctional proteins expressed by cells cultured from human arachnoid granulation tissue. Holman, D.W., Grzybowski, D.M., Mehta, B.C., Katz, S.E., Lubow, M. Cerebrospinal fluid research [electronic resource]. (2005) [Pubmed]
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