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Gene Review:

Pot1a - protection of telomeres 1A

Mus musculus

Synonyms: 1500031H18Rik, AI851169, POT1-like telomere end-binding protein, Pot1, Protection of telomeres protein 1, ...

Baumann, P., Wu, L. et al.

Baumann,

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High impact information on Pot1a

Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres [1].
Pot1 is a conserved single-stranded DNA binding protein with crucial functions in the protection of telomeres and maintenance of their length [2].
In this issue of Cell, two papers (Hockemeyer et al., 2006; Wu et al., 2006) examine the roles of murine Pot1 homologs and describe intriguing new insights into how cells protect their chromosome ends from DNA-repair activities [2].

References

Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres. Wu, L., Multani, A.S., He, H., Cosme-Blanco, W., Deng, Y., Deng, J.M., Bachilo, O., Pathak, S., Tahara, H., Bailey, S.M., Deng, Y., Behringer, R.R., Chang, S. Cell (2006) [Pubmed]
Are mouse telomeres going to pot? Baumann, P. Cell (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

POT1	Bos taurus
POT1	Canis lupus familiaris
pot1	Danio rerio
POT1	Gallus gallus
POT1	Homo sapiens
POT1	Macaca mulatta
POT1	Pan troglodytes
Pot1	Rattus norvegicus
pot1	Xenopus (Silurana) tropicalis

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