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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PLXNC1  -  plexin C1

Homo sapiens

Synonyms: CD232, PLXN-C1, Plexin-C1, VESPR, Virus-encoded semaphorin protein receptor
 
 
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High impact information on PLXNC1

  • A poxvirus-encoded semaphorin induces cytokine production from monocytes and binds to a novel cellular semaphorin receptor, VESPR [1].
  • Interestingly, we observed a complete down-regulation of plexin C1 expression during the in vitro differentiation process of monocytes to immature DCs, while concomitantly the surface expression of plexin B1 was induced [2].

References

  1. A poxvirus-encoded semaphorin induces cytokine production from monocytes and binds to a novel cellular semaphorin receptor, VESPR. Comeau, M.R., Johnson, R., DuBose, R.F., Petersen, M., Gearing, P., VandenBos, T., Park, L., Farrah, T., Buller, R.M., Cohen, J.I., Strockbine, L.D., Rauch, C., Spriggs, M.K. Immunity (1998) [Pubmed]
  2. Soluble CD100 functions on human monocytes and immature dendritic cells require plexin C1 and plexin B1, respectively. Chabbert-de Ponnat, I., Marie-Cardine, A., Pasterkamp, R.J., Schiavon, V., Tamagnone, L., Thomasset, N., Bensussan, A., Boumsell, L. Int. Immunol. (2005) [Pubmed]
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