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Gene Review:

phoA - alkaline phosphatase

Escherichia coli CFT073

Huang, X. et al., Barnich, N. et al., Fussenegger, M. et al.

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Disease relevance of phoA

Directed evolution of the 5'-untranslated region of the phoA gene in Escherichia coli simultaneously yields a stronger promoter and a stronger Shine-Dalgarno sequence [1].

High impact information on phoA

The 5' end of the coding sequence reveals a lipoprotein secretion signal shown to be functional by gene fusion with alkaline phosphatase (phoA') [2].
One mutant selected for its impaired ability to invade epithelial cells had an insertion of a Tn phoA transposon within the nlpI gene encoding the lipoprotein NlpI [3].

References

Directed evolution of the 5'-untranslated region of the phoA gene in Escherichia coli simultaneously yields a stronger promoter and a stronger Shine-Dalgarno sequence. Huang, X., Zhang, X.E., Zhou, Y.F., Zhang, Z.P., Cass, A.E. Biotechnology journal (2006) [Pubmed]
A novel peptidoglycan-linked lipoprotein (ComL) that functions in natural transformation competence of Neisseria gonorrhoeae. Fussenegger, M., Facius, D., Meier, J., Meyer, T.F. Mol. Microbiol. (1996) [Pubmed]
Involvement of lipoprotein NlpI in the virulence of adherent invasive Escherichia coli strain LF82 isolated from a patient with Crohn's disease. Barnich, N., Bringer, M.A., Claret, L., Darfeuille-Michaud, A. Infect. Immun. (2004) [Pubmed]

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