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Gene Review

phoA  -  alkaline phosphatase

Escherichia coli CFT073

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Disease relevance of phoA

  • Directed evolution of the 5'-untranslated region of the phoA gene in Escherichia coli simultaneously yields a stronger promoter and a stronger Shine-Dalgarno sequence [1].

High impact information on phoA

  • The 5' end of the coding sequence reveals a lipoprotein secretion signal shown to be functional by gene fusion with alkaline phosphatase (phoA') [2].
  • One mutant selected for its impaired ability to invade epithelial cells had an insertion of a Tn phoA transposon within the nlpI gene encoding the lipoprotein NlpI [3].


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