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Gene Review:

dksA - RNA polymerase-binding transcription factor

Escherichia coli CFT073

Kang, P.J. et al., Doran, T.J. et al.

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Disease relevance of dksA

The deduced product of traR was found to share amino acid similarity with proteins from the bacteriophages 186 and P2 and with the dosage-dependent dnaK suppressor DksA [1].
This gene was also able to suppress the temperature-sensitive growth of a grpE280 mutant strain at 41 degrees C. Filamentation of the grpE280 mutant strain was suppressed at 37 degrees C but not at 41 degrees C. The dnaK suppressor gene, designated dksA, maps near the mrcB gene (3.7 min on the E. coli chromosome) [2].

References

Molecular analysis of the F plasmid traVR region: traV encodes a lipoprotein. Doran, T.J., Loh, S.M., Firth, N., Skurray, R.A. J. Bacteriol. (1994) [Pubmed]
Identification and characterization of a new Escherichia coli gene that is a dosage-dependent suppressor of a dnaK deletion mutation. Kang, P.J., Craig, E.A. J. Bacteriol. (1990) [Pubmed]

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