Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

ada - ADA regulatory protein

Escherichia coli CFT073

Takahashi, K. et al., Nakabeppu, Y. et al., Takano, K. et al., McCarthy, T.V. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ada

Purification and structure of the intact Ada regulatory protein of Escherichia coli K12, O6-methylguanine-DNA methyltransferase [1].

High impact information on ada

In this process Ada protein, the product of the ada gene, plays a major role; it accepts the methyl groups of the methylated DNA at the cysteine residues of its own molecule, and the methylated form of Ada protein promotes transcription of its own gene, thereby triggering induction of the whole process [2].
Functional sites of the Ada regulatory protein of Escherichia coli. Analysis by amino acid substitutions [3].

Chemical compound and disease context of ada

Methyl phosphotriesters in alkylated DNA are repaired by the Ada regulatory protein of E. coli [4].

References

Purification and structure of the intact Ada regulatory protein of Escherichia coli K12, O6-methylguanine-DNA methyltransferase. Nakabeppu, Y., Kondo, H., Kawabata, S., Iwanaga, S., Sekiguchi, M. J. Biol. Chem. (1985) [Pubmed]
Activation of Ada protein as a transcriptional regulator by direct alkylation with methylating agents. Takahashi, K., Kawazoe, Y., Sakumi, K., Nakabeppu, Y., Sekiguchi, M. J. Biol. Chem. (1988) [Pubmed]
Functional sites of the Ada regulatory protein of Escherichia coli. Analysis by amino acid substitutions. Takano, K., Nakabeppu, Y., Sekiguchi, M. J. Mol. Biol. (1988) [Pubmed]
Methyl phosphotriesters in alkylated DNA are repaired by the Ada regulatory protein of E. coli. McCarthy, T.V., Lindahl, T. Nucleic Acids Res. (1985) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg